S 8666

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461659

CAS#: 103968-87-2

Description: S 8666 is a potent diuretic with uricosuric action.

Chemical Structure

img
S 8666
CAS# 103968-87-2
Instruction

Theoretical Analysis

MedKoo Cat#: 461659
Name: S 8666
CAS#: 103968-87-2
Chemical Formula: C11H11Cl2NO5S
Exact Mass: 338.97
Molecular Weight: 340.170
Elemental Analysis: C, 38.84; H, 3.26; Cl, 20.84; N, 4.12; O, 23.52; S, 9.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: S 8666; S-8666; S8666;

IUPAC/Chemical Name: 6,7-dichloro-5-(N,N-dimethylsulfamoyl)-2,3-dihydrobenzofuran-2-carboxylic acid

InChi Key: ZTFUDCAAHOVUPH-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H11Cl2NO5S/c1-14(2)20(17,18)7-4-5-3-6(11(15)16)19-10(5)9(13)8(7)12/h4,6H,3H2,1-2H3,(H,15,16)

SMILES Code: O=C(C1OC2=C(Cl)C(Cl)=C(S(=O)(N(C)C)=O)C=C2C1)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 340.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Shimizu T, Nakamura M, Imai M. Effect of S-8666 on Cl- transport in the rabbit connecting tubule perfused in vitro. Tohoku J Exp Med. 1991 Aug;164(4):293-8. PubMed PMID: 1746018.

2: Fujimura A, Ohashi K, Ebihara A. Chronopharmacology of the new uricosuric diuretic S-8666 in rats. Jpn J Pharmacol. 1991 May;56(1):105-8. PubMed PMID: 1880979.

3: Yonetani Y, Iwaki K, Shinosaki T, Kawase-Hanafusa A, Harada H, van Es AA. A new uricosuric diuretic, S-8666, in rats and chimpanzees. Jpn J Pharmacol. 1987 Apr;43(4):389-98. PubMed PMID: 3613285.

4: Shimizu T, Nakamura M, Imai M. Renal action of a novel uricosuric diuretic, S-8666. II. Effects on Cl- and urate transport in isolated perfused rabbit renal tubules. J Pharmacol Exp Ther. 1988 May;245(2):651-7. PubMed PMID: 3367311.

5: Fujimura A, Kajiyama H, Ohashi K, Ebihara A. Chronopharmacology of the new uricosuric diuretic S-8666 in rats: (II). Examination in aged rats. Jpn J Pharmacol. 1991 May;56(1):43-51. PubMed PMID: 1880985.

6: Nakano M, Kawahara S. Stereoselective renal tubular secretion of a new uricosuric diuretic, 6,7-dichloro-5-(N,N-dimethylsulfamoyl)-2,3-dihydro-2-benzofurancarboxyl ic acid (S-8666), in cynomolgus monkeys. Drug Metab Dispos. 1992 Mar-Apr;20(2):179-85. PubMed PMID: 1352207.

7: Shimizu T, Itoh T, Nakamura M. Additive diuretic effect of S-8666 during furosemide-induced diuresis in rats. J Pharmacol Exp Ther. 1989 Aug;250(2):659-66. PubMed PMID: 2760848.

8: Yonetani Y, Iwaki K, Ishii M, Harada H. A new diuretic that does not reduce renal handling of uric acid in rats, S-8666. Jpn J Pharmacol. 1987 Apr;43(4):399-405. PubMed PMID: 3613286.

9: Shimizu T, Miyata K, Nakamura M. Effect of S-8666 on urinary Ca++ excretion in rats. J Pharmacol Exp Ther. 1989 Aug;250(2):654-8. PubMed PMID: 2760847.

10: Shimuizu T, Nakamura M, Imai M. Renal action of a novel uricosuric diuretic, S-8666. I. Clearance and tubular microinjection studies in rats. J Pharmacol Exp Ther. 1988 May;245(2):644-50. PubMed PMID: 3367310.

11: Higaki K, Nakano M. Stereoselective disposition of S-8666, a novel uricosuric antihypertensive diuretic, and its N-monodemethylated metabolite in a perfused rat liver preparation. Effect of protein binding on the kinetics of S-8666. Drug Metab Dispos. 1992 May-Jun;20(3):350-5. PubMed PMID: 1355707.

12: Higaki J, Hirata M. Stereoselective glutathione conjugation of a uricosuric diuretic. Chem Biol Interact. 1989;72(1-2):209-14. PubMed PMID: 2582543.

13: Shinosaki T, Yonetani Y. Stop-flow studies on tubular transport of uric acid in rats. Adv Exp Med Biol. 1989;253A:293-300. PubMed PMID: 2624206.

14: Nakano M, Higaki K, Kawahara S. Enantiomer-enantiomer interaction of a uricosuric antihypertensive diuretic (DBCA) in renal tubular secretion and stereoselective inhibition by probenecid in the cynomolgus monkey. Xenobiotica. 1993 May;23(5):525-36. PubMed PMID: 8342300.

15: Higaki K, Kadono K, Goto S, Nakano M. Stereoselective renal tubular secretion of an organic anion in the isolated perfused rat kidney. J Pharmacol Exp Ther. 1994 Jul;270(1):329-35. PubMed PMID: 8035328.

16: Higaki K, Kadono K, Nakano M. Stereoselective pharmacokinetics of a novel uricosuric antihypertensive diuretic in rats: pharmacokinetic interaction between enantiomers. J Pharm Sci. 1992 Sep;81(9):935-9. PubMed PMID: 1432643.

17: Nakano M, Kawahara S. High-performance liquid chromatographic method for simultaneous determination of enantiomers of 5-dimethylsulphamoyl-6,7-dichloro-2-dihydrobenzofuran-2, carboxylic acid and its N-monodemethyl metabolite in monkey plasma and urine after chiral derivatization. J Chromatogr. 1991 Mar 8;564(1):235-41. PubMed PMID: 1860916.

18: Higaki J, Kikuchi J, Ikenishi Y, Hirata M. Structure determination of a diuretic-glutathione conjugate by mass and n.m.r. spectrometry. Xenobiotica. 1991 Jan;21(1):47-51. PubMed PMID: 2003366.

19: Kariya K, Okumura H, Lee E, Hirata M. Stereoselective conjugation of a uricosuric diuretic with glutathione by glutathione transferase 3-3. Xenobiotica. 1992 Mar;22(3):319-23. PubMed PMID: 1496822.