WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 461647
Description: S 4404 is a fluorescent peptide inhibitor of prolyl-4-hydroxylase.
MedKoo Cat#: 461647
Name: S 4404
Chemical Formula: C28H33N7O9
Exact Mass: 611.234
Molecular Weight: 611.61
Elemental Analysis: C, 54.99; H, 5.44; N, 16.03; O, 23.54
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: S 4404; S-4404; S4404;
IUPAC/Chemical Name: tert-butyl N-(isoxazolidine-3-carbonyl)-N-((3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)propanoyl)-L-phenylalanyl)glycinate
InChi Key: WXRFLNOCEIQEIV-ANYOKISRSA-N
InChi Code: InChI=1S/C28H33N7O9/c1-28(2,3)43-23(37)16-34(26(38)19-12-14-42-31-19)27(39)20(15-17-7-5-4-6-8-17)30-22(36)11-13-29-18-9-10-21(35(40)41)25-24(18)32-44-33-25/h4-10,19-20,29,31H,11-16H2,1-3H3,(H,30,36)/t19?,20-/m0/s1
SMILES Code: O=C(OC(C)(C)C)CN(C([C@H](CC1=CC=CC=C1)NC(CCNC2=CC=C([N+]([O-])=O)C3=NON=C23)=O)=O)C(C4NOCC4)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 611.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Kramer W, Wess G, Schubert G, Bickel M, Girbig F, Gutjahr U, Kowalewski S, Baringhaus KH, Enhsen A, Glombik H, et al. Liver-specific drug targeting by coupling to bile acids. J Biol Chem. 1992 Sep 15;267(26):18598-604. PubMed PMID: 1526993.
2: Meijer DK. Drug targeting to the liver with bile acids: the "Trojan horse" resurrected? Hepatology. 1993 May;17(5):945-8. PubMed PMID: 8491458.