Nadoxolol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 599080

CAS#: 54063-51-3

Description: Nadoxolol is an antiarrhythmic agent, chemically related in structure to beta-adrenergic receptor blocker drugs such as propranolol.


Price and Availability

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Nadoxolol is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 599080
Name: Nadoxolol
CAS#: 54063-51-3
Chemical Formula: C14H16N2O3
Exact Mass: 260.1161
Molecular Weight: 260.29
Elemental Analysis: C, 64.60; H, 6.20; N, 10.76; O, 18.44


Synonym: Nadoxolol; Nadoxololum; LL 1530; LL-1530; LL1530;

IUPAC/Chemical Name: (Z)-N',3-dihydroxy-4-(naphthalen-1-yloxy)butanimidamide

InChi Key: UPZVYDSBLFNMLK-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H16N2O3/c15-14(16-18)8-11(17)9-19-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11,17-18H,8-9H2,(H2,15,16)

SMILES Code: N/C(CC(O)COC1=C2C=CC=CC2=CC=C1)=N\O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.03.00


References

1: Jaeger A, Kopferschmitt J, Sauder P, Benmatti A, Mantz JM. [Acute nadoxolol poisoning. A multicentric study of 35 cases]. Toxicol Eur Res. 1982 May;4(3):163-6. French. PubMed PMID: 7135390.

2: Bernard P, Bedane C, Catanzano G, Robbe J, Bonnetblanc JM. Acute generalized exanthematic pustulosis. An atypical case due to nadoxolol? Dermatologica. 1991;182(2):115-8. PubMed PMID: 1828772.

3: Misztal G, Gumieniczek A. Chromatographic analysis (TLC) aprindine and nadoxolol in human plasma. Acta Pol Pharm. 1994;51(3):215-8. PubMed PMID: 7872014.

4: Misztal G, Przyborowski L. Determination of nadoxolol in human plasma using reversed-phase high-performance liquid chromatography. J Chromatogr B Biomed Appl. 1994 Oct 14;660(2):409-11. PubMed PMID: 7866535.

5: Jaeger A, Kopferschmitt J, Sauder P, Benmatti A, Mantz JM. [Acute poisoning caused by nadoxolol. Multi-center study of 35 cases]. Nouv Presse Med. 1982 Jun 12;11(28):2151-2. French. PubMed PMID: 7110977.

6: Mussini JM. [Peripheral neuropathy during treatment with nadoxolol]. Presse Med. 1985 Mar 30;14(13):748. French. PubMed PMID: 2986092.

7: Warembourg H, Ducloux G. [Clinical study of a new anti-arrhythmia agent: nadoxolol]. Lille Med. 1976 Apr;21(4 Suppl 2):386-8. French. PubMed PMID: 957857.

8: Kapoor M, Anand N, Koul S, Chimni SS, Manhas KS, Raina C, Parshad R, Taneja SC, Qazi GN. Kinetic resolution of 1-chloro-3-(1-naphthyloxy)-2-propanol, an intermediate in the synthesis of beta-adrenergic receptor blockers. Bioorg Chem. 2003 Jun;31(3):259-69. PubMed PMID: 12818235.