Neutramycin

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MedKoo CAT#: 599062

CAS#: 1404-08-6

Description: Neutramycin is an antibacterial agent.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-10-30. Prices are subject to change without notice.

Neutramycin is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 599062
Name: Neutramycin
CAS#: 1404-08-6
Chemical Formula: C34H54O14
Exact Mass: 686.3514
Molecular Weight: 686.79
Elemental Analysis: C, 59.46; H, 7.93; O, 32.61


Synonym: Neutramycin; LL-705 W; LL 705 W; LL705 W; AE-705W; AE 705W; AE705W; Neutramycinum;

IUPAC/Chemical Name: (1S,2R,3R,6E,8S,9S,12S,14E,16S)-12-hydroxy-2-((((2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)-9-(((2S,3R,4S,6R)-3-hydroxy-4-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,8,12-trimethyl-4,17-dioxabicyclo[14.1.0]heptadeca-6,14-diene-5,13-dione

InChi Key: RZLRMVZBGPHYJA-XXJPCBNGSA-N

InChi Code: InChI=1S/C34H54O14/c1-17-9-12-26(36)45-19(3)21(16-43-33-31(42-8)30(41-7)27(37)20(4)46-33)29-23(47-29)10-11-25(35)34(5,39)14-13-22(17)48-32-28(38)24(40-6)15-18(2)44-32/h9-12,17-24,27-33,37-39H,13-16H2,1-8H3/b11-10+,12-9+/t17-,18+,19+,20+,21+,22-,23-,24-,27+,28+,29-,30+,31+,32-,33+,34-/m0/s1

SMILES Code: C[C@@H]1C[C@H](OC)[C@@H](O)[C@H](O[C@H]2CC[C@](C)(O)C(/C=C/[C@H]3[C@H]([C@H](CO[C@H]4[C@H](OC)[C@H](OC)[C@H](O)[C@@H](C)O4)[C@@H](C)OC(/C=C/[C@@H]2C)=O)O3)=O)O1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Stulberg ER, Lozano GL, Morin JB, Park H, Baraban EG, Mlot C, Heffelfinger C, Phillips GM, Rush JS, Phillips AJ, Broderick NA, Thomas MG, Stabb EV, Handelsman J. Genomic and Secondary Metabolite Analyses of Streptomyces sp. 2AW Provide Insight into the Evolution of the Cycloheximide Pathway. Front Microbiol. 2016 May 3;7:573. doi: 10.3389/fmicb.2016.00573. eCollection 2016. PubMed PMID: 27199910; PubMed Central PMCID: PMC4853412.

2: Mitscher LA, Kunstmann MP. The structure of neutramycin. Experientia. 1969 Jan 15;25(1):12-3. PubMed PMID: 5766558.

3: Kunstmann MP, Mitscher LA. Some additional observations on the chemical nature of neutramycin. Experientia. 1965 Jul 15;21(7):372-3. PubMed PMID: 5870757.

4: LEFEMINE DV, BARBATSCHI F, DANN M, THOMAS SO, KUNSTMANN MP, MITSCHER LA, BOHONOS N. NEUTRAMYCIN, A NEW NEUTRAL MACROLIDE ANTIBIOTIC. Antimicrob Agents Chemother (Bethesda). 1963;161:41-4. PubMed PMID: 14274934.

5: Graziani EI, Overk CR, Carter GT. Purification, structure determination, and antimicrobial activity of neutramycins B-G. J Nat Prod. 2003 Sep;66(9):1149-53. PubMed PMID: 14510587.