UK-78282 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563615

CAS#: 136647-02-4 (HCl)

Description: UK-78282 HCl is a blocker of the KV1.3 and KV1.4 voltage-gated potassium channels.

Chemical Structure

UK-78282 HCl
CAS# 136647-02-4 (HCl)

Theoretical Analysis

MedKoo Cat#: 563615
Name: UK-78282 HCl
CAS#: 136647-02-4 (HCl)
Chemical Formula: C29H36ClNO2
Exact Mass: 465.24
Molecular Weight: 466.060
Elemental Analysis: C, 74.74; H, 7.79; Cl, 7.61; N, 3.01; O, 6.87

Price and Availability

Size Price Availability Quantity
10mg USD 425 2 Weeks
50mg USD 1550 2 Weeks
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Related CAS #: 191217-42-2 (free base)   136647-02-4 (HCl)    

Synonym: UK-78282 Hydrochloride; UK 78282 Hydrochloride; UK78282 Hydrochloride; UK-78282 HCl; UK 78282 HCl; UK78282 HCl;

IUPAC/Chemical Name: 4-(Benzhydryloxymethyl)-1-[3-(4-methoxyphenyl)propyl]piperidine hydrochloride


InChi Code: InChI=1S/C29H35NO2.ClH/c1-31-28-16-14-24(15-17-28)9-8-20-30-21-18-25(19-22-30)23-32-29(26-10-4-2-5-11-26)27-12-6-3-7-13-27;/h2-7,10-17,25,29H,8-9,18-23H2,1H3;1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 466.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hanson DC, Nguyen A, Mather RJ, Rauer H, Koch K, Burgess LE, Rizzi JP, Donovan CB, Bruns MJ, Canniff PC, Cunningham AC, Verdries KA, Mena E, Kath JC, Gutman GA, Cahalan MD, Grissmer S, Chandy KG. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation. Br J Pharmacol. 1999 Apr;126(8):1707-16. PubMed PMID: 10372812; PubMed Central PMCID: PMC1565958.