CINPA1
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MedKoo CAT#: 563612

CAS#: 102636-74-8

Description: CINPA1 is a potent constitutive androstane receptor (CAR) antagonist, not activating pregnane X receptor.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 295 2 Weeks
50mg USD 775 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-20. Prices are subject to change without notice.

CINPA1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563612
Name: CINPA1
CAS#: 102636-74-8
Chemical Formula: C23H29N3O3
Exact Mass: 395.2209
Molecular Weight: 395.5
Elemental Analysis: C, 69.85; H, 7.39; N, 10.62; O, 12.14


Synonym: CINPA1; CINPA-1; CINPA 1;

IUPAC/Chemical Name: Ethyl [5-[(diethylamino)acetyl]-10,11-dihydro-5H-dibenz[b,f]azepin-3-yl]carbamate

InChi Key: AYQBYSPEGRYKFA-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H29N3O3/c1-4-25(5-2)16-22(27)26-20-10-8-7-9-17(20)11-12-18-13-14-19(15-21(18)26)24-23(28)29-6-3/h7-10,13-15H,4-6,11-12,16H2,1-3H3,(H,24,28)

SMILES Code: O=C(OCC)NC1=CC=C2C(N(C(CN(CC)CC)=O)C3=CC=CC=C3CC2)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Cherian MT, Chai SC, Wright WC, Singh A, Alexandra Casal M, Zheng J, Wu J, Lee RE, Griffin PR, Chen T. CINPA1 binds directly to constitutive androstane receptor and inhibits its activity. Biochem Pharmacol. 2018 Jun;152:211-223. doi: 10.1016/j.bcp.2018.03.029. Epub 2018 Mar 31. PubMed PMID: 29608908; PubMed Central PMCID: PMC5960625.

2: Jeske J, Windshügel B, Thasler WE, Schwab M, Burk O. Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor. Arch Toxicol. 2017 Jun;91(6):2375-2390. doi: 10.1007/s00204-017-1948-3. Epub 2017 Mar 13. PubMed PMID: 28289823.

3: Cherian MT, Yang L, Chai SC, Lin W, Chen T. Identification and Characterization of CINPA1 Metabolites Facilitates Structure-Activity Studies of the Constitutive Androstane Receptor. Drug Metab Dispos. 2016 Nov;44(11):1759-1770. Epub 2016 Aug 12. PubMed PMID: 27519550; PubMed Central PMCID: PMC5074473.

4: Lin W, Yang L, Chai SC, Lu Y, Chen T. Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor. Eur J Med Chem. 2016 Jan 27;108:505-528. doi: 10.1016/j.ejmech.2015.12.018. Epub 2015 Dec 15. PubMed PMID: 26717202; PubMed Central PMCID: PMC4724233.

5: Cherian MT, Lin W, Wu J, Chen T. CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Mol Pharmacol. 2015 May;87(5):878-89. doi: 10.1124/mol.115.097782. Epub 2015 Mar 11. PubMed PMID: 25762023; PubMed Central PMCID: PMC4407736.