ICI-185282

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563596

CAS#: 106393-80-0

Description: ICI-185282 is a potent thromboxane receptor antagonist.


Chemical Structure

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ICI-185282
CAS# 106393-80-0

Theoretical Analysis

MedKoo Cat#: 563596
Name: ICI-185282
CAS#: 106393-80-0
Chemical Formula: C18H21F3O5
Exact Mass: 374.1341
Molecular Weight: 374.35
Elemental Analysis: C, 57.75; H, 5.65; F, 15.22; O, 21.37

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: ICI-185282; ICI 185282; ICI185282;

IUPAC/Chemical Name: (Z)-7-[(2S,4S,5R)-4-(2-Hydroxyphenyl)-2-(trifluoromethyl)-1,3-dioxan-5-yl]hept-5-enoic acid

InChi Key: ZWAVGFSZMACJHA-PMNBYGLBSA-N

InChi Code: InChI=1S/C18H21F3O5/c19-18(20,21)17-25-11-12(7-3-1-2-4-10-15(23)24)16(26-17)13-8-5-6-9-14(13)22/h1,3,5-6,8-9,12,16-17,22H,2,4,7,10-11H2,(H,23,24)/b3-1-/t12-,16+,17+/m1/s1

SMILES Code: O=C(O)CCC/C=C\C[C@H]1[C@@H](C2=CC=CC=C2O)O[C@@H](C(F)(F)F)OC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 374.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Westwood FR, Duffy PA, Malpass DA, Jones HB, Topham JC. Disturbance of macrophage and monocyte function in the dog by a thromboxane receptor antagonist: ICI 185,282. Toxicol Pathol. 1995 May-Jun;23(3):373-84. PubMed PMID: 7659959.

2: Kanzik I, Zengil H, Ipek N, Cakici I, Abacioglu N, Dörtlemez H. Synergism between UK 38485 and ICI 185282 against digoxin-induced arrhythmias in guinea-pigs. Arch Int Pharmacodyn Ther. 1991 Jul-Aug;312:55-65. PubMed PMID: 1772341.

3: Taylor A, Williams DA, Wilson ID. Derivatized beta-cyclodextrins combined with high field NMR for enantiomer analysis: application to ICI 185,282 (5(Z)-7- ([2RS,4RS,5SR]-4-o-hydroxyphenyl-2-trifluoromethyl-1,3-dioxan-5-yl) heptenoic acid). J Pharm Biomed Anal. 1991;9(6):493-6. PubMed PMID: 1747402.

4: Kanzik I, Demiryürek AT, Zengil H, Abacioğlu N, Dörtlemez H. Effects of thromboxane synthetase inhibitor (UK 38,485) and thromboxane receptor antagonist (ICI 185,282) on digoxin-induced arrhythmias in anaesthetized guinea-pigs. Clin Exp Pharmacol Physiol. 1988 Dec;15(12):927-35. PubMed PMID: 3243019.

5: Birch J, Brown E, Calnan C, Jessup CL, Jessup R, Wayne M. Studies in the guinea-pig with ICI 185,282: a thromboxane A2 receptor antagonist. J Pharm Pharmacol. 1988 Oct;40(10):706-10. PubMed PMID: 2907537.

6: Swayne GT, Maguire J, Dolan J, Raval P, Dane G, Greener M, Owen DA. Evidence for homogeneity of thromboxane A2 receptor using structurally different antagonists. Eur J Pharmacol. 1988 Aug 2;152(3):311-9. PubMed PMID: 2975605.