7-NINA
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563595

CAS#: 161467-34-1

Description: 7-NINA is a non-selective NOS inhibitor.


Chemical Structure

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7-NINA
CAS# 161467-34-1

Theoretical Analysis

MedKoo Cat#: 563595
Name: 7-NINA
CAS#: 161467-34-1
Chemical Formula: C7H4N3NaO2
Exact Mass:
Molecular Weight: 185.11
Elemental Analysis: C, 45.42; H, 2.18; N, 22.70; Na, 12.42; O, 17.29

Price and Availability

Size Price Availability Quantity
10.0mg USD 235.0 2 Weeks
50.0mg USD 675.0 2 Weeks
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Synonym: 7-NINA; 7 NINA; 7NINA; IN1195; 7-Nitroindazole sodium salt; IN-1195; IN 1195;

IUPAC/Chemical Name: sodium 7-nitroindazol-2-ide

InChi Key: DJMLKKIIBMJGIQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C7H4N3O2.Na/c11-10(12)6-3-1-2-5-4-8-9-7(5)6;/h1-4H;/q-1;+1

SMILES Code: O=[N+](C1=CC=CC2=C[N-]N=C12)[O-].[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 185.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Prast H, Hornick A, Kraus MM, Philippu A. Origin of endogenous nitric oxide released in the nucleus accumbens under real-time in vivo conditions. Life Sci. 2015 Aug 1;134:79-84. doi: 10.1016/j.lfs.2015.04.021. Epub 2015 May 23. PubMed PMID: 26006039.

2: Rathnasamy G, Sivakumar V, Rangarajan P, Foulds WS, Ling EA, Kaur C. NF-κB-mediated nitric oxide production and activation of caspase-3 cause retinal ganglion cell death in the hypoxic neonatal retina. Invest Ophthalmol Vis Sci. 2014 Aug 19;55(9):5878-89. doi: 10.1167/iovs.13-13718. PubMed PMID: 25139733.

3: Diéguez G, García-Villalón AL. Dilator and constrictor response of renal vasculature during acute renal hypotension in anesthetized goats. Role of nitric oxide. Vascul Pharmacol. 2011 Mar-Jun;54(3-6):107-11. doi: 10.1016/j.vph.2011.04.002. Epub 2011 May 6. PubMed PMID: 21571096.

4: Tjong YW, Ip SP, Lao L, Wu J, Fong HH, Sung JJ, Berman B, Che CT. Role of neuronal nitric oxide synthase in colonic distension-induced hyperalgesia in distal colon of neonatal maternal separated male rats. Neurogastroenterol Motil. 2011 Jul;23(7):666-e278. doi: 10.1111/j.1365-2982.2011.01697.x. Epub 2011 Mar 16. PubMed PMID: 21410601; PubMed Central PMCID: PMC3117987.

5: Chen Y, Boettger MK, Reif A, Schmitt A, Uçeyler N, Sommer C. Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice. Mol Pain. 2010 Mar 2;6:13. doi: 10.1186/1744-8069-6-13. PubMed PMID: 20193086; PubMed Central PMCID: PMC2838835.

6: de Buys Roessingh AS, de Lagausie P, Ebrahimian T, Duong-Quy S, Schneider JC, Huang XL, Mercier JC, Aigrain Y, Boulanger C, Dinh-Xuan AT. Neuronal nitric oxide synthase does not contribute to the modulation of pulmonary vascular tone in fetal lambs with congenital diaphragmatic hernia (nNOS in CDH lambs). Pediatr Pulmonol. 2008 Apr;43(4):313-21. doi: 10.1002/ppul.20796. Erratum in: Pediatr Pulmonol. 2008 Jul;43(7):727-8. Ibrahima, Taline [corrected to Ebrahimian, Taline]. PubMed PMID: 18306337.

7: Stegbauer J, Kuczka Y, Vonend O, Quack I, Sellin L, Patzak A, Steege A, Langnaese K, Rump LC. Endothelial nitric oxide synthase is predominantly involved in angiotensin II modulation of renal vascular resistance and norepinephrine release. Am J Physiol Regul Integr Comp Physiol. 2008 Feb;294(2):R421-8. Epub 2007 Nov 28. PubMed PMID: 18046021.

8: Liu W, Wang CH, Cui Y, Mo LQ, Zhi JL, Sun SN, Wang YL, Yu HM, Zhao CM, Feng JQ, Chen PX. Inhibition of neuronal nitric oxide synthase antagonizes morphine antinociceptive tolerance by decreasing activation of p38 MAPK in the spinal microglia. Neurosci Lett. 2006 Dec 27;410(3):174-7. Epub 2006 Nov 13. PubMed PMID: 17101217.

9: Mishra OP, Zubrow AB, Ashraf QM, Delivoria-Papadopoulos M. Nuclear Ca(++)-influx, Ca (++)/calmodulin-dependent protein kinase IV activity and CREB protein phosphorylation during post-hypoxic reoxygenation in neuronal nuclei of newborn piglets: the role of nitric oxide. Neurochem Res. 2006 Dec;31(12):1463-71. Epub 2006 Nov 8. PubMed PMID: 17091402.

10: Valencia I, Mishra OP, Fritz K, Zubrow A, Katsetos CD, Delivoria-Papadopoulos M, Legido A. Increased neuronal nuclear calcium influx in neonatal seizures. Neurochem Res. 2006 Oct;31(10):1231-7. Epub 2006 Sep 27. PubMed PMID: 17004131.

11: Katsetos CD, Parikh NA, Fritz KI, Legido A, Delivoria-Papadopoulos M, Mishra OP. Effect of 7-nitroindazole sodium on the cellular distribution of neuronal nitric oxide synthase in the cerebral cortex of hypoxic newborn piglets. Neurochem Res. 2006 Jul;31(7):899-906. Epub 2006 Jun 29. PubMed PMID: 16804757.

12: Fan MX, Li X, Wang J, Cao YX, Shen LL, Zhu DN. Effect of adrenomedullin on the activity of barosensitive neurons in the rostral ventrolateral medulla of rats. Sheng Li Xue Bao. 2006 Jun 25;58(3):193-200. PubMed PMID: 16786102.

13: Mishra OP, Zubrow AB, Ashraf QM, Delivoria-Papadopoulos M. Effect of nitric oxide synthase inhibition during post-hypoxic reoxygenation on Bax and Bcl-2 protein expression and DNA fragmentation in neuronal nuclei of newborn piglets. Brain Res. 2006 Jul 26;1101(1):20-8. Epub 2006 Jun 16. PubMed PMID: 16781684.

14: Mishra OP, Delivoria-Papadopoulos M. Effect of neuronal nitric oxide synthase inhibition on caspase-9 activity during hypoxia in the cerebral cortex of newborn piglets. Neurosci Lett. 2006 Jun 19;401(1-2):81-5. Epub 2006 Mar 20. PubMed PMID: 16545906.

15: Engel DC, Slemmer JE, Vlug AS, Maas AI, Weber JT. Combined effects of mechanical and ischemic injury to cortical cells: secondary ischemia increases damage and decreases effects of neuroprotective agents. Neuropharmacology. 2005 Dec;49(7):985-95. Epub 2005 Jul 25. PubMed PMID: 16046227.

16: Harvey BH, Bothma T, Nel A, Wegener G, Stein DJ. Involvement of the NMDA receptor, NO-cyclic GMP and nuclear factor K-beta in an animal model of repeated trauma. Hum Psychopharmacol. 2005 Jul;20(5):367-73. PubMed PMID: 15912566.

17: Schlemper V, Medeiros R, Ferreira J, Campos MM, Calixto JB. Mechanisms underlying the relaxation response induced by bradykinin in the epithelium-intact guinea-pig trachea in vitro. Br J Pharmacol. 2005 Jul;145(6):740-50. PubMed PMID: 15852038; PubMed Central PMCID: PMC1576187.

18: Mishra OP, Delivoria-Papadopoulos M. Effect of hypoxia on the expression and activity of mitogen-activated protein (MAP) kinase-phosphatase-1 (MKP-1) and MKP-3 in neuronal nuclei of newborn piglets: the role of nitric oxide. Neuroscience. 2004;129(3):665-73. PubMed PMID: 15541888.

19: Mishra OP, Delivoria-Papadopoulos M. Effect of hypoxia on protein tyrosine kinase activity in cortical membranes of newborn piglets--the role of nitric oxide. Neurosci Lett. 2004 Nov 30;372(1-2):114-8. PubMed PMID: 15531099.

20: Holguin A, O'Connor KA, Biedenkapp J, Campisi J, Wieseler-Frank J, Milligan ED, Hansen MK, Spataro L, Maksimova E, Bravmann C, Martin D, Fleshner M, Maier SF, Watkins LR. HIV-1 gp120 stimulates proinflammatory cytokine-mediated pain facilitation via activation of nitric oxide synthase-I (nNOS). Pain. 2004 Aug;110(3):517-30. PubMed PMID: 15288392.

7-NINA

10.0mg / USD 235.0