Calycosin
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563593

CAS#: 20575-57-9

Description: Calycosin is a phytoestrogen, exhibiting anti-apoptotic effects by activating ERα/ß and enhancing Akt phosphorylation in cardiomyocytes.


Chemical Structure

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Calycosin
CAS# 20575-57-9

Theoretical Analysis

MedKoo Cat#: 563593
Name: Calycosin
CAS#: 20575-57-9
Chemical Formula: C16H12O5
Exact Mass: 284.0685
Molecular Weight: 284.26
Elemental Analysis: C, 67.60; H, 4.26; O, 28.14

Price and Availability

Size Price Availability Quantity
10.0mg USD 430.0 2 Weeks
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Synonym: Calycosin;

IUPAC/Chemical Name: 7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one

InChi Key: ZZAJQOPSWWVMBI-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H12O5/c1-20-14-5-2-9(6-13(14)18)12-8-21-15-7-10(17)3-4-11(15)16(12)19/h2-8,17-18H,1H3

SMILES Code: O=C1C(C2=CC=C(OC)C(O)=C2)=COC3=C1C=CC(O)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 284.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Chen HS, Chen X, Li WT, Shen JG. Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery. Acta Pharmacol Sin. 2018 May;39(5):669-682. doi: 10.1038/aps.2018.27. Epub 2018 Mar 29. Review. PubMed PMID: 29595191; PubMed Central PMCID: PMC5943912.

2: Kong X, Wang F, Niu Y, Wu X, Pan Y. A comparative study on the effect of promoting the osteogenic function of osteoblasts using isoflavones from Radix Astragalus. Phytother Res. 2018 Jan;32(1):115-124. doi: 10.1002/ptr.5955. Epub 2017 Oct 18. Review. PubMed PMID: 29044703.

3: Zhang DQ, Wang HB, Wang SF, Wang DQ. [Research achievements on biological activities of calycosin]. Zhongguo Zhong Yao Za Zhi. 2015 Nov;40(22):4339-45. Review. Chinese. PubMed PMID: 27097403.

4: Gong AG, Li N, Lau KM, Lee PS, Yan L, Xu ML, Lam CT, Kong AY, Lin HQ, Dong TT, Tsim KW. Calycosin orchestrates the functions of Danggui Buxue Tang, a Chinese herbal decoction composing of Astragali Radix and Angelica Sinensis Radix: An evaluation by using calycosin-knock out herbal extract. J Ethnopharmacol. 2015 Jun 20;168:150-7. doi: 10.1016/j.jep.2015.03.033. Epub 2015 Mar 19. Review. PubMed PMID: 25796405.

5: Gao J, Liu ZJ, Chen T, Zhao D. Pharmaceutical properties of calycosin, the major bioactive isoflavonoid in the dry root extract of Radix astragali. Pharm Biol. 2014 Sep;52(9):1217-22. doi: 10.3109/13880209.2013.879188. Epub 2014 Mar 17. Review. PubMed PMID: 24635389.

6: Majewska I, Gendaszewska-Darmach E. Proangiogenic activity of plant extracts in accelerating wound healing - a new face of old phytomedicines. Acta Biochim Pol. 2011;58(4):449-60. Epub 2011 Oct 27. Review. PubMed PMID: 22030557.