S 135

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MedKoo CAT#: 461612

CAS#: 104679-67-6

Description: S 135 is a benzodiazepine receptor inverse agonist.

Chemical Structure

S 135
CAS# 104679-67-6

Theoretical Analysis

MedKoo Cat#: 461612
Name: S 135
CAS#: 104679-67-6
Chemical Formula: C15H11N3OS
Exact Mass: 281.0623
Molecular Weight: 281.33
Elemental Analysis: C, 64.04; H, 3.94; N, 14.94; O, 5.69; S, 11.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: S 135; S-135; S135;

IUPAC/Chemical Name: 2-(5-methylthiophen-3-yl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one


InChi Code: InChI=1S/C15H11N3OS/c1-9-6-10(8-20-9)18-15(19)12-7-16-13-5-3-2-4-11(13)14(12)17-18/h2-8,16H,1H3


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 281.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Yasui M, Kawasaki K, Matsushita A, Satoh M. Benzodiazepine inverse agonists augment long-term potentiation in CA1 and CA3 of guinea pig hippocampal slices. Neuropharmacology. 1993 Feb;32(2):127-31. PubMed PMID: 8383812.

2: Ikenishi R, Kitagawa T. Fluorometric determination of an inverse agonist to benzodiazepine receptors S-135 in monkey plasma by high performance liquid chromatography. Chem Pharm Bull (Tokyo). 1991 Oct;39(10):2739-41. PubMed PMID: 1666862.

3: Matsushita A, Kawasaki K, Matsubara K, Eigyo M, Shindo H, Takada S. Activation of brain function by S-135, a benzodiazepine receptor inverse agonist. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(6):951-66. PubMed PMID: 2853884.