WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 461612
CAS#: 104679-67-6
Description: S 135 is a benzodiazepine receptor inverse agonist.
MedKoo Cat#: 461612
Name: S 135
CAS#: 104679-67-6
Chemical Formula: C15H11N3OS
Exact Mass: 281.0623
Molecular Weight: 281.33
Elemental Analysis: C, 64.04; H, 3.94; N, 14.94; O, 5.69; S, 11.40
This product is not in stock, which may be available by custom synthesis.
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Synonym: S 135; S-135; S135;
IUPAC/Chemical Name: 2-(5-methylthiophen-3-yl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one
InChi Key: APOGOWTZFFKBRQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H11N3OS/c1-9-6-10(8-20-9)18-15(19)12-7-16-13-5-3-2-4-11(13)14(12)17-18/h2-8,16H,1H3
SMILES Code: O=C1N(C2=CSC(C)=C2)N=C3C1=CNC4=C3C=CC=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 281.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Yasui M, Kawasaki K, Matsushita A, Satoh M. Benzodiazepine inverse agonists augment long-term potentiation in CA1 and CA3 of guinea pig hippocampal slices. Neuropharmacology. 1993 Feb;32(2):127-31. PubMed PMID: 8383812.
2: Ikenishi R, Kitagawa T. Fluorometric determination of an inverse agonist to benzodiazepine receptors S-135 in monkey plasma by high performance liquid chromatography. Chem Pharm Bull (Tokyo). 1991 Oct;39(10):2739-41. PubMed PMID: 1666862.
3: Matsushita A, Kawasaki K, Matsubara K, Eigyo M, Shindo H, Takada S. Activation of brain function by S-135, a benzodiazepine receptor inverse agonist. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(6):951-66. PubMed PMID: 2853884.
