711389-S

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461611

CAS#: 94899-83-9

Description: 711389-S is an antiarrhythmic agent.


Chemical Structure

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711389-S
CAS# 94899-83-9

Theoretical Analysis

MedKoo Cat#: 461611
Name: 711389-S
CAS#: 94899-83-9
Chemical Formula: C17H21Cl2N3O2
Exact Mass: 369.1011
Molecular Weight: 370.27
Elemental Analysis: C, 55.14; H, 5.72; Cl, 19.15; N, 11.35; O, 8.64

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: 711389-S; 711389 S; 711389S; S 1389; S-1389; S1389;

IUPAC/Chemical Name: (S)-1-(2-(1-(1H-imidazol-1-yl)vinyl)-3,6-dichlorophenoxy)-3-(isopropylamino)propan-2-ol

InChi Key: DROIRVKNZDBEFR-ZDUSSCGKSA-N

InChi Code: InChI=1S/C17H21Cl2N3O2/c1-11(2)21-8-13(23)9-24-17-15(19)5-4-14(18)16(17)12(3)22-7-6-20-10-22/h4-7,10-11,13,21,23H,3,8-9H2,1-2H3/t13-/m0/s1

SMILES Code: O[C@@H](CNC(C)C)COC1=C(Cl)C=CC(Cl)=C1C(N2C=CN=C2)=C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 370.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Kotake H, Hisatome I, Hasegawa J, Yamasaki J, Kosaka T, Furuse T, Mashiba H. Inhibitory action of 711389-S on the electrical activity of rabbit sinoatrial node. Cardiovasc Res. 1987 Mar;21(3):197-201. PubMed PMID: 3652085.

2: Ninomiya M, Tani T, Ueda M. Effects of S-1389 (711389-S), a new antiarrhythmic agent, on the conduction in perfused guinea pig hearts. Jpn J Pharmacol. 1989 Dec;51(4):555-62. PubMed PMID: 2615048.

3: Iwaki K, Ishii M, Shinosaki T, Ueda M, Yonetani Y. Effect of 711389-S, a new antiarrhythmic agent, on myocardial energy metabolism in guinea-pigs and rats. J Pharm Pharmacol. 1988 Jan;40(1):10-6. PubMed PMID: 2896767.

4: Nakajima S, Ueda M. Increase of the ventricular fibrillation threshold by 711389-S, a new antiarrhythmic agent, in guinea-pigs. Jpn J Pharmacol. 1985 Aug;38(4):436-8. PubMed PMID: 3840850.

5: Kadowaki Y, Ohta T, Hotokebuchi N, Kimoto S, Haruna M, Nakao T, Ueda M, Nishi K. Actions of a newly synthesized compound (711389-S) on various types of experimentally induced arrhythmias in mammalian species in situ. Jpn J Pharmacol. 1988 Apr;46(4):359-72. PubMed PMID: 3404766.

6: Ninomiya M, Toyama J, Kodama I, Yamada K. Electrophysiological effects of 711389-S, a new antiarrhythmic agent, on guinea-pig isolated cardiac muscle. J Cardiovasc Pharmacol. 1984 Nov-Dec;6(6):1222-9. PubMed PMID: 6084783.

7: Muramatsu I, Noda M, Nishio M, Fujiwara M. Mechanism of sodium channel block in crayfish giant axons by 711389-S, a new antiarrhythmic drug. J Pharmacol Exp Ther. 1987 Jul;242(1):269-76. PubMed PMID: 2441025.

8: Hisatome I, Matsuoka S, Miyamoto J, Sawaguchi M, Omodani H, Osaki S, Kotake H, Mashiba H, Sato R. Blocking effect of 1389-S on the sodium current in isolated guinea-pig ventricular myocytes. Eur J Pharmacol. 1990 Apr 25;179(3):447-51. PubMed PMID: 2163858.