WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 461609
Description: S 12340 is a potent inhibitor of the oxidative modification of low-density lipoprotein.
MedKoo Cat#: 461609
Name: S 12340
Chemical Formula: C24H38N2O3S
Exact Mass: 434.2603
Molecular Weight: 434.63
Elemental Analysis: C, 66.32; H, 8.81; N, 6.45; O, 11.04; S, 7.38
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: S 12340; S-12340; S12340;
IUPAC/Chemical Name: 8-(3-((3,5-di-tert-butyl-4-hydroxyphenyl)thio)propyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
InChi Key: AQYBPUABOQSUHO-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H38N2O3S/c1-22(2,3)18-14-17(15-19(20(18)27)23(4,5)6)30-13-7-10-26-11-8-24(9-12-26)16-25-21(28)29-24/h14-15,27H,7-13,16H2,1-6H3,(H,25,28)
SMILES Code: O=C1OC2(CCN(CCCSC3=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C3)CC2)CN1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 434.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Breugnot C, Privat S, Guillonneau C, Regnier G, Bouzom F, Vilaine JP, Lenaers A. S 12340: a potent inhibitor of the oxidative modification of low-density lipoprotein in vitro and ex vivo in WHHL rabbits. J Pharmacol Exp Ther. 1994 May;269(2):515-20. PubMed PMID: 8182520.
2: Iliou JP, Thollon C, Robin F, Cambarrat C, Guillonneau C, Régnier G, Lenaers A, Vilaine JP. Protective effect of S12340 on cardiac cells exposed to oxidative stress. Eur J Pharmacol. 1993 Oct 1;248(3):263-72. PubMed PMID: 8293791.