DBCO-acid
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 572247

CAS#: 1353016-70-2

Description: DBCO-acid is a non-activated building block and adds minimal spacer to modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize amine-containing molecules through a stable amide bond.

Chemical Structure

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DBCO-acid
CAS# 1353016-70-2
Instruction

Theoretical Analysis

MedKoo Cat#: 572247
Name: DBCO-acid
CAS#: 1353016-70-2
Chemical Formula: C19H15NO3
Exact Mass: 305.11
Molecular Weight: 305.330
Elemental Analysis: C, 74.74; H, 4.95; N, 4.59; O, 15.72

Price and Availability

Size Price Availability Quantity
100mg USD 420
1g USD 2275
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Synonym: DBCO-acid

IUPAC/Chemical Name: 11,12-Didehydro-γ-oxodibenz[b,f]azocine-5(6H)-butanoic acid

InChi Key: NDLOVDOICXITOK-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H15NO3/c21-18(11-12-19(22)23)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13H2,(H,22,23)

SMILES Code: O=C(CCC(O)=O)N1CC2=C(C=CC=C2)C#CC3=C1C=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 305.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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IC, Cho YW, Kim K. Bioorthogonal Copper Free Click Chemistry for Labeling and
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Uter NT, Yin G, Rivers PJ, Yam AY, Wang WD, Steiner AR, Bajad SU, Penta K, Yang
W, Hallam TJ, Thanos CD, Sato AK. Production of site-specific antibody-drug
conjugates using optimized non-natural amino acids in a cell-free expression
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2014 Jan 29. PubMed PMID: 24437342.