UCL-1684 Br
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MedKoo CAT#: 563563

CAS#: 199934-16-2

Description: UCL-1684 Br is a potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1).


Price and Availability

Size Price Shipping out time Quantity
5mg USD 295 2 Weeks
10mg USD 485 2 Weeks
25mg USD 865 2 Weeks
50mg USD 1355 2 Weeks
100mg USD 2065 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-31. Prices are subject to change without notice.

UCL-1684 Br, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563563
Name: UCL-1684 Br
CAS#: 199934-16-2
Chemical Formula: C34H30Br2N4
Exact Mass: 652.0837
Molecular Weight: 654.45
Elemental Analysis: C, 62.40; H, 4.62; Br, 24.42; N, 8.56


Synonym: UCL-1684 Dibromide; UCL 1684 Dibromide; UCL1684 Dibromide; UCL-1684 Br; UCL 1684 Br; UCL1684 Br;

IUPAC/Chemical Name: 6,10-diaza-1,5(1,4)-diquinolin-1-iuma-3(1,3),8(1,4)-dibenzenacyclodecaphane-11,51-diium bromide

InChi Key: KPNMQIKQVCWNTP-IQRNGZOLSA-N

InChi Code: InChI=1S/C34H28N4.2BrH/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31;;/h1-20H,21-24H2;2*1H/b35-31-,36-32-;;

SMILES Code: C12=CC=CC=C1C(NCC3=CC=C(C=C3)CNC4=CC=[N+]5C6=C4C=CC=C6)=CC=[N+]2CC7=CC=CC(C5)=C7.[Br-].[Br-]


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Abdulkareem ZA, Gee JM, Cox CD, Wann KT. Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. Br J Pharmacol. 2016 Jan;173(1):177-90. doi: 10.1111/bph.13357. Epub 2015 Dec 5. PubMed PMID: 26454020; PubMed Central PMCID: PMC4737296.

2: Xu YC, Leung SW, Leung GP, Man RY. Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca(2+) -activated K(+) channels. Br J Pharmacol. 2015 Jun;172(12):3003-14. doi: 10.1111/bph.13108. Epub 2015 Mar 27. PubMed PMID: 25652142; PubMed Central PMCID: PMC4459019.

3: Feetham CH, Nunn N, Lewis R, Dart C, Barrett-Jolley R. TRPV4 and K(Ca) ion channels functionally couple as osmosensors in the paraventricular nucleus. Br J Pharmacol. 2015 Apr;172(7):1753-68. doi: 10.1111/bph.13023. Epub 2015 Jan 23. PubMed PMID: 25421636; PubMed Central PMCID: PMC4376454.

4: Toniolo EF, Maique ET, Ferreira WA Jr, Heimann AS, Ferro ES, Ramos-Ortolaza DL, Miller L, Devi LA, Dale CS. Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats. Peptides. 2014 Jun;56:125-31. doi: 10.1016/j.peptides.2014.03.016. Epub 2014 Apr 3. PubMed PMID: 24703998; PubMed Central PMCID: PMC4112957.

5: Chennupati R, Lamers WH, Koehler SE, De Mey JG. Endothelium-dependent hyperpolarization-related relaxations diminish with age in murine saphenous arteries of both sexes. Br J Pharmacol. 2013 Aug;169(7):1486-99. doi: 10.1111/bph.12175. PubMed PMID: 23488619; PubMed Central PMCID: PMC3724106.

6: Chubanov V, Mederos y Schnitzler M, Meißner M, Schäfer S, Abstiens K, Hofmann T, Gudermann T. Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7. Br J Pharmacol. 2012 Jun;166(4):1357-76. doi: 10.1111/j.1476-5381.2012.01855.x. PubMed PMID: 22242975; PubMed Central PMCID: PMC3417452.

7: Schmidt K, Dubrovska G, Nielsen G, Fesüs G, Uhrenholt TR, Hansen PB, Gudermann T, Dietrich A, Gollasch M, de Wit C, Köhler R. Amplification of EDHF-type vasodilatations in TRPC1-deficient mice. Br J Pharmacol. 2010 Dec;161(8):1722-33. doi: 10.1111/j.1476-5381.2010.00985.x. PubMed PMID: 20718731; PubMed Central PMCID: PMC3010578.

8: Sones WR, Leblanc N, Greenwood IA. Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels. Br J Pharmacol. 2009 Sep;158(2):521-31. doi: 10.1111/j.1476-5381.2009.00332.x. Epub 2009 Jul 23. PubMed PMID: 19645713; PubMed Central PMCID: PMC2757692.

9: Michel FS, Man GS, Man RY, Vanhoutte PM. Hypertension and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat. Br J Pharmacol. 2008 Sep;155(2):217-26. doi: 10.1038/bjp.2008.256. Epub 2008 Jun 23. PubMed PMID: 18574459; PubMed Central PMCID: PMC2538696.

10: Gluais P, Edwards G, Weston AH, Falck JR, Vanhoutte PM, Félétou M. Role of SK(Ca) and IK(Ca) in endothelium-dependent hyperpolarizations of the guinea-pig isolated carotid artery. Br J Pharmacol. 2005 Feb;144(4):477-85. PubMed PMID: 15655533; PubMed Central PMCID: PMC1576024.

11: Andersson DA, Zygmunt PM, Movahed P, Andersson TL, Högestätt ED. Effects of inhibitors of small- and intermediate-conductance calcium-activated potassium channels, inwardly-rectifying potassium channels and Na(+)/K(+) ATPase on EDHF relaxations in the rat hepatic artery. Br J Pharmacol. 2000 Apr;129(7):1490-6. PubMed PMID: 10742306; PubMed Central PMCID: PMC1571979.

12: Malik-Hall M, Ganellin CR, Galanakis D, Jenkinson DH. Compounds that block both intermediate-conductance (IK(Ca)) and small-conductance (SK(Ca)) calcium-activated potassium channels. Br J Pharmacol. 2000 Apr;129(7):1431-8. PubMed PMID: 10742299; PubMed Central PMCID: PMC1571984.

13: Strøbaek D, Jørgensen TD, Christophersen P, Ahring PK, Olesen SP. Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9. PubMed PMID: 10696100; PubMed Central PMCID: PMC1571906.