Nomilinic acid glycoside

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MedKoo CAT#: 598903

CAS#: 125107-15-5

Description: Nomilinic acid glycoside is a limonoid glucoside in the peel of Citrus tangerina.


Chemical Structure

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Nomilinic acid glycoside
CAS# 125107-15-5

Theoretical Analysis

MedKoo Cat#: 598903
Name: Nomilinic acid glycoside
CAS#: 125107-15-5
Chemical Formula: C34H48O16
Exact Mass: 712.29
Molecular Weight: 712.740
Elemental Analysis: C, 57.30; H, 6.79; O, 35.92

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Nomilinic acid glycoside; Nomilinic acid 17-O-beta-D-glucoside;

IUPAC/Chemical Name: (1R,2S,3'S,4aR,5R,6R,8aR)-5-((R)-1-acetoxy-2-carboxyethyl)-2-((S)-furan-3-yl(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)-6-(2-hydroxypropan-2-yl)-2,5,8a-trimethyl-8-oxooctahydro-2H-spiro[naphthalene-1,2'-oxirane]-3'-carboxylic acid

InChi Key: MUZNNCNJBAPYJF-RFDVNOEESA-N

InChi Code: InChI=1S/C34H48O16/c1-15(36)47-21(12-22(38)39)32(5)18-7-9-31(4,34(27(50-34)28(43)44)33(18,6)20(37)11-19(32)30(2,3)45)26(16-8-10-46-14-16)49-29-25(42)24(41)23(40)17(13-35)48-29/h8,10,14,17-19,21,23-27,29,35,40-42,45H,7,9,11-13H2,1-6H3,(H,38,39)(H,43,44)/t17-,18-,19+,21-,23-,24+,25-,26+,27-,29+,31+,32-,33+,34-/m1/s1

SMILES Code: O=C(O)C[C@@H](OC(C)=O)[C@]([C@H](C(C)(O)C)C1)(C)[C@@]2([H])CC[C@@](C)([C@H](C3=COC=C3)O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O)[C@@]5(O[C@@H]5C(O)=O)[C@]2(C)C1=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 712.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jayaprakasha GK, Dandekar DV, Tichy SE, Patil BS. Simultaneous separation and identification of limonoids from citrus using liquid chromatography-collision-induced dissociation mass spectra. J Sep Sci. 2011 Jan;34(1):2-10. doi: 10.1002/jssc.201000644. Epub 2010 Nov 26. PubMed PMID: 21171170.

2: Tian Q, Schwartz SJ. Mass spectrometry and tandem mass spectrometry of citrus limonoids. Anal Chem. 2003 Oct 15;75(20):5451-60. PubMed PMID: 14710824.

3: Cheung TK, Li W, Ho HM, Liang ZT, Huang CQ. [Chemical variation in Aurantii Fructus before and after processing based on UHPLC-Q-TOF-MS]. Zhongguo Zhong Yao Za Zhi. 2016 Jun;41(11):2070-2080. doi: 10.4268/cjcmm20161116. Chinese. PubMed PMID: 28901103.

4: Tian Q, Miller EG, Ahmad H, Tang L, Patil BS. Differential inhibition of human cancer cell proliferation by citrus limonoids. Nutr Cancer. 2001;40(2):180-4. PubMed PMID: 11962254.

5: Miller EG, Gonzales-Sanders AP, Couvillon AM, Wright JM, Hasegawa S, Lam LK. Inhibition of hamster buccal pouch carcinogenesis by limonin 17-beta-D-glucopyranoside. Nutr Cancer. 1992;17(1):1-7. PubMed PMID: 1574440.

6: Vikram A, Jayaprakasha GK, Patil BS. Simultaneous determination of citrus limonoid aglycones and glucosides by high performance liquid chromatography. Anal Chim Acta. 2007 May 8;590(2):180-6. Epub 2007 Mar 18. PubMed PMID: 17448343.

7: Raman G, Cho M, Brodbelt JS, Patil BS. Isolation and purification of closely related citrus limonoid glucosides by flash chromatography. Phytochem Anal. 2005 May-Jun;16(3):155-60. PubMed PMID: 15997847.

8: Sawabe A, Morita M, Kiso T, Kishine H, Ohtsubo Y, Minematsu T, Matsubara Y, Okamoto T. Isolation and characterization of new limonoid glycosides from Citrus unshiu peels. Carbohydr Res. 1999 Jan 31;315(1-2):142-7. PubMed PMID: 10385977.