Virustomycin A | CAS# 84777-85-5 | Antibiotic

Virustomycin A
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592749

CAS#: 84777-85-5

Description: Virustomycin A is a macrolide antibiotic active against infectious and plant pathogenic fungi. It decreases plaque formation by RNA and DNA viruses.

Chemical Structure

Virustomycin A

CAS# 84777-85-5

Instruction

Theoretical Analysis

MedKoo Cat#: 592749
Name: Virustomycin A
CAS#: 84777-85-5
Chemical Formula: C48H71NO14
Exact Mass: 885.49
Molecular Weight: 886.089
Elemental Analysis: C, 65.06; H, 8.08; N, 1.58; O, 25.28

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 280
5mg	USD 935
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Virustomycin A; Antibiotic AM-2604 A

IUPAC/Chemical Name: Concanamycin A, 23-O-de(4-O-(aminocarbonyl)-2,6-dideoxy-beta-D-arabino-hexopyranosyl)-23-O-(4-((2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino)-1,4-dioxo-2-butenyl)-

InChi Key: YIKWIQAIKGWYCF-QTAFVZCYSA-N

InChi Code: InChI=1S/C48H71NO14/c1-12-15-36-30(7)39(61-41(53)21-20-40(52)49-42-34(50)18-19-35(42)51)25-48(58,63-36)32(9)45(56)31(8)46-37(59-10)17-14-16-26(3)22-28(5)43(54)33(13-2)44(55)29(6)23-27(4)24-38(60-11)47(57)62-46/h12,14-17,20-21,23-24,28-33,36-37,39,43-46,50,54-56,58H,13,18-19,22,25H2,1-11H3,(H,49,52)/b15-12-,17-14+,21-20+,26-16+,27-23-,38-24-/t28-,29-,30-,31+,32+,33+,36-,37+,39-,43+,44-,45-,46+,48-/m1/s1

SMILES Code: C(\C=C\C(=O)NC1=C(CCC1=O)O)(=O)O[C@@H]1C[C@](O[C@@H]([C@H]1C)\C=C/C)(O)[C@H]([C@@H]([C@H](C)[C@@H]1OC(C(=CC(=C[C@H]([C@H]([C@H]([C@H]([C@@H](CC(=CC=C[C@@H]1OC)C)C)O)CC)O)C)C)OC)=O)O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 886.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Otoguro K, Ishiyama A, Namatame M, Nishihara A, Furusawa T, Masuma R, Shiomi K, Takahashi Y, Yamada H, Omura S. Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites. J Antibiot (Tokyo). 2008 Jun;61(6):372-8. doi: 10.1038/ja.2008.52. PubMed PMID: 18667785.

2: Hayakawa Y, Takaku K, Furihata K, Nagai K, Seto H. Isolation and structural elucidation of new 18-membered macrolide antibiotics, viranamycins A and B. J Antibiot (Tokyo). 1991 Dec;44(12):1294-9. PubMed PMID: 1778781.

3: Omura S, Imamura N, Hinotozawa K, Otoguro K, Lukacs G, Faghih R, Tolmann R, Arison BH, Smith JL. The structure of virustomycin A. J Antibiot (Tokyo). 1983 Dec;36(12):1783-6. PubMed PMID: 6662820.

4: Omura S, Otoguro K, Tanaka H. The mode of action of a novel 18-membered macrolide, virustomycin A (AM-2604 A), on Trichomonas foetus. J Antibiot (Tokyo). 1983 Dec;36(12):1755-61. PubMed PMID: 6662816.

5: Omura S, Shimizu H, Iwai Y, Hinotozawa K, Otoguro K, Hashimoto H, Nakagawa A. AM-2604 A, a new antiviral antibiotic produced by a strain of Streptomyces. J Antibiot (Tokyo). 1982 Dec;35(12):1632-7. PubMed PMID: 7166528.

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Virustomycin A featured