WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598885

CAS#: 33889-68-8

Description: Fangchinoline is an isolate from Stephania Tetrandra that shows anti-cancer activity. It inhibits breast adenocarcinoma proliferation through apoptosis induction. In addition, it has been shown to inhibit HIV-Type 1 replication.

Chemical Structure

CAS# 33889-68-8

Theoretical Analysis

MedKoo Cat#: 598885
Name: Fangchinoline
CAS#: 33889-68-8
Chemical Formula: C37H40N2O6
Exact Mass: 608.2886
Molecular Weight: 608.73
Elemental Analysis: C, 73.01; H, 6.62; N, 4.60; O, 15.77

Price and Availability

Size Price Availability Quantity
20.0mg USD 350.0 2 weeks
50.0mg USD 550.0 2 weeks
100.0mg USD 950.0 2 weeks
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Related CAS #: 436-77-1   33889-68-8    

Synonym: Fangchinoline; NSC 277171; NSC-277171; NSC277171; Isofangchinoline; Thaligine; Thalrugosine; (+)-Limacine, 7-O-Demethyltetrandine;

IUPAC/Chemical Name: (11S,31R)-16,36,54-trimethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphan-37-ol


InChi Code: InChI=1S/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-32-18-23(8-11-30(32)41-3)17-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3/t28-,29+/m0/s1

SMILES Code: CN1CCc2c([C@@H]1Cc3ccc(Oc4c(OC)ccc(C[C@@H]5c6c(O7)c(O)c(OC)cc6CCN5C)c4)cc3)cc7c(OC)c2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 608.73 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Guo B, Su J, Zhang T, Wang K, Li X. Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549. J Drug Target. 2015 Apr;23(3):266-74. doi: 10.3109/1061186X.2014.992898. Epub 2014 Dec 24. PubMed PMID: 25539072.

2: Li D, Lu Y, Sun P, Feng LX, Liu M, Hu LH, Wu WY, Jiang BH, Yang M, Qu XB, Guo DA, Liu X. Inhibition on Proteasome β1 Subunit Might Contribute to the Anti-Cancer Effects of Fangchinoline in Human Prostate Cancer Cells. PLoS One. 2015 Oct 29;10(10):e0141681. doi: 10.1371/journal.pone.0141681. eCollection 2015. PubMed PMID: 26512898; PubMed Central PMCID: PMC4626104.

3: Tian F, Ding D, Li D. Fangchinoline targets PI3K and suppresses PI3K/AKT signaling pathway in SGC7901 cells. Int J Oncol. 2015;46(6):2355-63. doi: 10.3892/ijo.2015.2959. Epub 2015 Apr 9. PubMed PMID: 25872479; PubMed Central PMCID: PMC4441295.

4: Xing Z, Zhang Y, Zhang X, Yang Y, Ma Y, Pang D. Fangchinoline induces G1 arrest in breast cancer cells through cell-cycle regulation. Phytother Res. 2013 Dec;27(12):1790-4. doi: 10.1002/ptr.4936. Epub 2013 Feb 11. PubMed PMID: 23401195.

5: Lu X, Zhang R, Fu F, Shen J, Nian H, Wu T. Simultaneous Determination of Fangchinoline and Tetrandrine in Qi-Fang-Xi-Bi-Granules by RP-HPLC. J Chromatogr Sci. 2015 Sep;53(8):1328-32. doi: 10.1093/chromsci/bmv016. Epub 2015 Mar 8. PubMed PMID: 25754692.

6: Sun YF, Wink M. Tetrandrine and fangchinoline, bisbenzylisoquinoline alkaloids from Stephania tetrandra can reverse multidrug resistance by inhibiting P-glycoprotein activity in multidrug resistant human cancer cells. Phytomedicine. 2014 Jul-Aug;21(8-9):1110-9. doi: 10.1016/j.phymed.2014.04.029. Epub 2014 May 22. PubMed PMID: 24856768.

7: Wang X, Liu X, Cai H, Pei K, Cao G, Xu X, Shi F, Cai B. Ultra high performance liquid chromatography with tandem mass spectrometry method for the determination of tetrandrine and fangchinoline in rat plasma after oral administration of Fangji Huangqi Tang and Stephania tetrandra S. Moore extracts. J Sep Sci. 2015 May;38(8):1286-93. doi: 10.1002/jssc.201401384. Epub 2015 Mar 10. PubMed PMID: 25645647.

8: Guo B, Xie P, Su J, Zhang T, Li X, Liang G. Fangchinoline suppresses the growth and invasion of human glioblastoma cells by inhibiting the kinase activity of Akt and Akt-mediated signaling cascades. Tumour Biol. 2016 Feb;37(2):2709-19. doi: 10.1007/s13277-015-3990-1. Epub 2015 Sep 25. PubMed PMID: 26408176.

9: Wang CD, Yuan CF, Bu YQ, Wu XM, Wan JY, Zhang L, Hu N, Liu XJ, Zu Y, Liu GL, Song FZ. Fangchinoline inhibits cell proliferation via Akt/GSK-3beta/ cyclin D1 signaling and induces apoptosis in MDA-MB-231 breast cancer cells. Asian Pac J Cancer Prev. 2014;15(2):769-73. PubMed PMID: 24568493.

10: Wan Z, Lu Y, Liao Q, Wu Y, Chen X. Fangchinoline inhibits human immunodeficiency virus type 1 replication by interfering with gp160 proteolytic processing. PLoS One. 2012;7(6):e39225. doi: 10.1371/journal.pone.0039225. Epub 2012 Jun 13. PubMed PMID: 22720080; PubMed Central PMCID: PMC3374765.

11: Xing ZB, Yao L, Zhang GQ, Zhang XY, Zhang YX, Pang D. Fangchinoline inhibits breast adenocarcinoma proliferation by inducing apoptosis. Chem Pharm Bull (Tokyo). 2011;59(12):1476-80. PubMed PMID: 22130369.

12: Wang Y, Chen J, Wang L, Huang Y, Leng Y, Wang G. Fangchinoline induces G0/G1 arrest by modulating the expression of CDKN1A and CCND2 in K562 human chronic myelogenous leukemia cells. Exp Ther Med. 2013 Apr;5(4):1105-1112. Epub 2013 Jan 24. PubMed PMID: 23596478; PubMed Central PMCID: PMC3627453.

13: Wang N, Pan W, Zhu M, Zhang M, Hao X, Liang G, Feng Y. Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells. Br J Pharmacol. 2011 Sep;164(2b):731-42. doi: 10.1111/j.1476-5381.2011.01349.x. PubMed PMID: 21418191; PubMed Central PMCID: PMC3188903.

14: Tang Y, Sun A, Liu R, Zhang Y. Simultaneous determination of fangchinoline and tetrandrine in Stephania tetrandra S. Moore by using 1-alkyl-3-methylimidazolium-based ionic liquids as the RP-HPLC mobile phase additives. Anal Chim Acta. 2013 Mar 12;767:148-54. doi: 10.1016/j.aca.2013.01.001. Epub 2013 Jan 9. PubMed PMID: 23452799.

15: Bao X, Hu M, Zhang Y, Machibya F, Zhang Y, Jiang H, Yu D. Effect of fangchinoline on root resorption during rat orthodontic tooth movement. Korean J Orthod. 2012 Jun;42(3):138-43. doi: 10.4041/kjod.2012.42.3.138. Epub 2012 Jun 28. PubMed PMID: 23112944; PubMed Central PMCID: PMC3481979.

16: Luo X, Peng JM, Su LD, Wang DY, Yu YJ. Fangchinoline inhibits the proliferation of SPC-A-1 lung cancer cells by blocking cell cycle progression. Exp Ther Med. 2016 Feb;11(2):613-618. Epub 2015 Dec 4. PubMed PMID: 26893655; PubMed Central PMCID: PMC4734059.

17: He L, Yang J, Hu L. [Transmembrane transport activity of paclitaxel regulated by fangchinoline in MDR1-mDCK II cells]. Zhongguo Zhong Yao Za Zhi. 2010 Jun;35(11):1478-81. Chinese. PubMed PMID: 20822025.

18: Lin TY, Lu CW, Tien LT, Chuang SH, Wang YR, Chang WH, Wang SJ. Fangchinoline inhibits glutamate release from rat cerebral cortex nerve terminals (synaptosomes). Neurochem Int. 2009 Jul;54(8):506-12. doi: 10.1016/j.neuint.2009.02.001. Epub 2009 Feb 21. PubMed PMID: 19428795.

19: Tsutsumi T, Kobayashi S, Liu YY, Kontani H. Anti-hyperglycemic effect of fangchinoline isolated from Stephania tetrandra Radix in streptozotocin-diabetic mice. Biol Pharm Bull. 2003 Mar;26(3):313-7. PubMed PMID: 12612439.

20: Choi HS, Kim HS, Min KR, Kim Y, Lim HK, Chang YK, Chung MW. Anti-inflammatory effects of fangchinoline and tetrandrine. J Ethnopharmacol. 2000 Feb;69(2):173-9. PubMed PMID: 10687873.