Nylestriol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598879

CAS#: 39791-20-3

Description: Nylestriol is an estrogen receptor agonist.

Chemical Structure

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Nylestriol
CAS# 39791-20-3
Instruction

Theoretical Analysis

MedKoo Cat#: 598879
Name: Nylestriol
CAS#: 39791-20-3
Chemical Formula: C25H32O3
Exact Mass: 380.24
Molecular Weight: 380.520
Elemental Analysis: C, 78.91; H, 8.48; O, 12.61

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Nylestriol; 49825; Lilly 49825; LY 49825; LY-49825; LY49825; Nilestriolum;

IUPAC/Chemical Name: (8R,9S,13S,14S,16R,17R)-3-(cyclopentyloxy)-17-ethynyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-16,17-diol

InChi Key: CHZJRGNDJLJLAW-RIQJQHKOSA-N

InChi Code: InChI=1S/C25H32O3/c1-3-25(27)23(26)15-22-21-10-8-16-14-18(28-17-6-4-5-7-17)9-11-19(16)20(21)12-13-24(22,25)2/h1,9,11,14,17,20-23,26-27H,4-8,10,12-13,15H2,2H3/t20-,21-,22+,23-,24+,25+/m1/s1

SMILES Code: C#C[C@@]1(O)[C@](CC[C@H]2[C@H]3CCc4cc(OC5CCCC5)ccc42)(C)[C@H]3C[C@H]1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 380.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Li XF, Lin CB, Xie FR, Liang WG, Ji J, Yang Y. Effects of Simvastatin and Combination of Simvastatin and Nylestriol on Bone Metabolism in Ovariectomized Rats. Am J Ther. 2016 Nov/Dec;23(6):e1630-e1636. PubMed PMID: 26171988.

2: Liao EY, Luo XH, Deng XG, Wu XP, Liao HJ, Wang PF, Mao JP, Zhu XP, Huang G, Wei QY. The effect of low dose nylestriol-levonorgestrel replacement therapy on bone mineral density in women with postmenopausal osteoporosis. Endocr Res. 2003 May;29(2):217-26. PubMed PMID: 12856809.

3: Yang K, Liao E, Zhou H. [Effect of nylestriol and levonorgestrel on the expression of estrogen receptor subtypes in human osteosarcoma MG-63 cell lines]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Dec;35(12):1248-53. doi: 10.3969/j.issn.1672-7347.2010.12.008. Chinese. PubMed PMID: 21200092.

4: Cheng GJ, Liu JL, Zhang Q, Fan W, Ye HF, Wang ZQ, Pan HP. Nylestriol replacement therapy in postmenopausal women. A three-year prospective study. Chin Med J (Engl). 1993 Dec;106(12):911-6. PubMed PMID: 8198628.

5: Yang KC, Liao EY, Zhou HD, Xiao XH. [Effect of nylestriol and levonorgestrel on the expression of Opg/OPGL in human osteosarcoma MG-63 cell lines]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Dec;29(6):667-70. Chinese. PubMed PMID: 16114553.

6: Cheng GJ. [Prospective study on nylestriol replacement therapy in postmenopausal women]. Zhonghua Fu Chan Ke Za Zhi. 1993 Sep;28(9):534-8, 569. Chinese. PubMed PMID: 8313746.

7: Zhu M, Liu Z, Zhang X. [Study of nylestriol effect on bone histomorphometric parameters in ovariectomized rats]. Zhonghua Fu Chan Ke Za Zhi. 1999 Feb;34(2):86-9. Chinese. PubMed PMID: 11263204.

8: Shi W, Du N, Fu S. [Histomorphometric study of the effect of nylestriol on bone turnover in ovariectomized rabbits]. Zhonghua Fu Chan Ke Za Zhi. 1997 Sep;32(9):544-7. Chinese. PubMed PMID: 9639756.

9: Wang BL, Jia HW, Quan JX, Qiu MC, Zhang JY. [Effect of nylestriol on bone remodeling in ovariectomized rats]. Zhonghua Bing Li Xue Za Zhi. 2004 Jun;33(3):255-9. Chinese. PubMed PMID: 15256120.

10: Xie W, Ziheng Q, Lei G, Qiu D, Han S, Han Z. [Anti-implantation action of nylestriol and its effect on uterine cytosol estrogen and progesterone receptor in rabbits]. Hua Xi Yi Ke Da Xue Xue Bao. 1993 Jun;24(2):163-6. Chinese. PubMed PMID: 8244294.

11: Ma Q, Zhou H, Sun M, Wu S. [Relationship between sex hormone levels and blood lipids/immunity in perimenopausal women]. Hunan Yi Ke Da Xue Xue Bao. 1998;23(5):461-4. Chinese. PubMed PMID: 10682561.

12: Xie W, Zheng Q, Lei G, Han Z. [Anti-implantation action of nylestriol and its effect on endometrium in rabbits]. Hua Xi Yi Ke Da Xue Xue Bao. 1994 Mar;25(1):45-9. Chinese. PubMed PMID: 8070771.

13: Liu SP, Liao EY, Wu XP, Luo XH, Li HD, Chen ZN, Dai RC, Sun RY, Liu XJ. [Compound nylestriol tablet to prevent bone loss in osteoporotic rats]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Aug;29(4):405-9. Chinese. PubMed PMID: 16134591.

14: Jiang B, Liao EY, Tan LM, Dai RC, Xiao ZJ, Liao HJ. [Effects of long-term replacement therapy of compound nylestriol tablet or low-dose 17 beta-estradiol on the expression of nerve growth factor in OVX rat hippocampal formation]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Oct;29(5):529-33. Chinese. PubMed PMID: 16137039.

15: Liu JL. [Effect of nylestriol on postmenopausal uterine endometrium]. Zhonghua Fu Chan Ke Za Zhi. 1993 Feb;28(2):76-8, 122. Chinese. PubMed PMID: 8344085.

16: Liao EY, Luo XH, Wang WB, Wu XP, Zhou HD, Dai RC, Liao HJ, Yang C. Effects of different nylestriol/levonorgestrel dosages on bone metabolism in female Sprague-Dawley rats with retinoic acid-induced osteoporosis. Endocr Res. 2003 Feb;29(1):23-42. PubMed PMID: 12665316.

17: Cheng GJ. [A prospective study of nylestriol on plasma lipids in postmenopausal women]. Zhonghua Fu Chan Ke Za Zhi. 1991 Nov;26(6):349-51, 387-8. Chinese. PubMed PMID: 1804605.

18: Qi B, Fan L, Jiang H, Zhang L, He X, Wan T, Cai C, Deng X, Tian X. [Protective effect of estrogens replacement on apoptosis cells of nasal mocosas in ovariectomized rats]. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Mar;19(5):222-4. Chinese. PubMed PMID: 15934292.

19: Dai L, Wu H, Yu S, Zhao H, Xue L, Xu M, Shen Z, Hu M. Effects of OsteoKing on osteoporotic rabbits. Mol Med Rep. 2015 Jul;12(1):1066-74. doi: 10.3892/mmr.2015.3551. Epub 2015 Mar 26. PubMed PMID: 25815520; PubMed Central PMCID: PMC4438876.

20: Nian H, Ma MH, Nian SS, Xu LL. Antiosteoporotic activity of icariin in ovariectomized rats. Phytomedicine. 2009 Apr;16(4):320-6. doi: 10.1016/j.phymed.2008.12.006. Epub 2009 Mar 6. PubMed PMID: 19269147.