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MedKoo CAT#: 598879

CAS#: 39791-20-3

Description: Nylestriol is an estrogen receptor agonist.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-09-22. Prices are subject to change without notice.

Nylestriol is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 598879
Name: Nylestriol
CAS#: 39791-20-3
Chemical Formula: C25H32O3
Exact Mass: 380.2351
Molecular Weight: 380.52
Elemental Analysis: C, 78.91; H, 8.48; O, 12.61

Synonym: Nylestriol; 49825; Lilly 49825; LY 49825; LY-49825; LY49825; Nilestriolum;

IUPAC/Chemical Name: (8R,9S,13S,14S,16R,17R)-3-(cyclopentyloxy)-17-ethynyl-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-16,17-diol


InChi Code: InChI=1S/C25H32O3/c1-3-25(27)23(26)15-22-21-10-8-16-14-18(28-17-6-4-5-7-17)9-11-19(16)20(21)12-13-24(22,25)2/h1,9,11,14,17,20-23,26-27H,4-8,10,12-13,15H2,2H3/t20-,21-,22+,23-,24+,25+/m1/s1

SMILES Code: C#C[C@@]1(O)[C@](CC[C@H]2[C@H]3CCc4cc(OC5CCCC5)ccc42)(C)[C@H]3C[C@H]1O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Li XF, Lin CB, Xie FR, Liang WG, Ji J, Yang Y. Effects of Simvastatin and Combination of Simvastatin and Nylestriol on Bone Metabolism in Ovariectomized Rats. Am J Ther. 2016 Nov/Dec;23(6):e1630-e1636. PubMed PMID: 26171988.

2: Liao EY, Luo XH, Deng XG, Wu XP, Liao HJ, Wang PF, Mao JP, Zhu XP, Huang G, Wei QY. The effect of low dose nylestriol-levonorgestrel replacement therapy on bone mineral density in women with postmenopausal osteoporosis. Endocr Res. 2003 May;29(2):217-26. PubMed PMID: 12856809.

3: Yang K, Liao E, Zhou H. [Effect of nylestriol and levonorgestrel on the expression of estrogen receptor subtypes in human osteosarcoma MG-63 cell lines]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010 Dec;35(12):1248-53. doi: 10.3969/j.issn.1672-7347.2010.12.008. Chinese. PubMed PMID: 21200092.

4: Cheng GJ, Liu JL, Zhang Q, Fan W, Ye HF, Wang ZQ, Pan HP. Nylestriol replacement therapy in postmenopausal women. A three-year prospective study. Chin Med J (Engl). 1993 Dec;106(12):911-6. PubMed PMID: 8198628.

5: Yang KC, Liao EY, Zhou HD, Xiao XH. [Effect of nylestriol and levonorgestrel on the expression of Opg/OPGL in human osteosarcoma MG-63 cell lines]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Dec;29(6):667-70. Chinese. PubMed PMID: 16114553.

6: Cheng GJ. [Prospective study on nylestriol replacement therapy in postmenopausal women]. Zhonghua Fu Chan Ke Za Zhi. 1993 Sep;28(9):534-8, 569. Chinese. PubMed PMID: 8313746.

7: Zhu M, Liu Z, Zhang X. [Study of nylestriol effect on bone histomorphometric parameters in ovariectomized rats]. Zhonghua Fu Chan Ke Za Zhi. 1999 Feb;34(2):86-9. Chinese. PubMed PMID: 11263204.

8: Shi W, Du N, Fu S. [Histomorphometric study of the effect of nylestriol on bone turnover in ovariectomized rabbits]. Zhonghua Fu Chan Ke Za Zhi. 1997 Sep;32(9):544-7. Chinese. PubMed PMID: 9639756.

9: Wang BL, Jia HW, Quan JX, Qiu MC, Zhang JY. [Effect of nylestriol on bone remodeling in ovariectomized rats]. Zhonghua Bing Li Xue Za Zhi. 2004 Jun;33(3):255-9. Chinese. PubMed PMID: 15256120.

10: Xie W, Ziheng Q, Lei G, Qiu D, Han S, Han Z. [Anti-implantation action of nylestriol and its effect on uterine cytosol estrogen and progesterone receptor in rabbits]. Hua Xi Yi Ke Da Xue Xue Bao. 1993 Jun;24(2):163-6. Chinese. PubMed PMID: 8244294.

11: Ma Q, Zhou H, Sun M, Wu S. [Relationship between sex hormone levels and blood lipids/immunity in perimenopausal women]. Hunan Yi Ke Da Xue Xue Bao. 1998;23(5):461-4. Chinese. PubMed PMID: 10682561.

12: Xie W, Zheng Q, Lei G, Han Z. [Anti-implantation action of nylestriol and its effect on endometrium in rabbits]. Hua Xi Yi Ke Da Xue Xue Bao. 1994 Mar;25(1):45-9. Chinese. PubMed PMID: 8070771.

13: Liu SP, Liao EY, Wu XP, Luo XH, Li HD, Chen ZN, Dai RC, Sun RY, Liu XJ. [Compound nylestriol tablet to prevent bone loss in osteoporotic rats]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Aug;29(4):405-9. Chinese. PubMed PMID: 16134591.

14: Jiang B, Liao EY, Tan LM, Dai RC, Xiao ZJ, Liao HJ. [Effects of long-term replacement therapy of compound nylestriol tablet or low-dose 17 beta-estradiol on the expression of nerve growth factor in OVX rat hippocampal formation]. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Oct;29(5):529-33. Chinese. PubMed PMID: 16137039.

15: Liu JL. [Effect of nylestriol on postmenopausal uterine endometrium]. Zhonghua Fu Chan Ke Za Zhi. 1993 Feb;28(2):76-8, 122. Chinese. PubMed PMID: 8344085.

16: Liao EY, Luo XH, Wang WB, Wu XP, Zhou HD, Dai RC, Liao HJ, Yang C. Effects of different nylestriol/levonorgestrel dosages on bone metabolism in female Sprague-Dawley rats with retinoic acid-induced osteoporosis. Endocr Res. 2003 Feb;29(1):23-42. PubMed PMID: 12665316.

17: Cheng GJ. [A prospective study of nylestriol on plasma lipids in postmenopausal women]. Zhonghua Fu Chan Ke Za Zhi. 1991 Nov;26(6):349-51, 387-8. Chinese. PubMed PMID: 1804605.

18: Qi B, Fan L, Jiang H, Zhang L, He X, Wan T, Cai C, Deng X, Tian X. [Protective effect of estrogens replacement on apoptosis cells of nasal mocosas in ovariectomized rats]. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Mar;19(5):222-4. Chinese. PubMed PMID: 15934292.

19: Dai L, Wu H, Yu S, Zhao H, Xue L, Xu M, Shen Z, Hu M. Effects of OsteoKing on osteoporotic rabbits. Mol Med Rep. 2015 Jul;12(1):1066-74. doi: 10.3892/mmr.2015.3551. Epub 2015 Mar 26. PubMed PMID: 25815520; PubMed Central PMCID: PMC4438876.

20: Nian H, Ma MH, Nian SS, Xu LL. Antiosteoporotic activity of icariin in ovariectomized rats. Phytomedicine. 2009 Apr;16(4):320-6. doi: 10.1016/j.phymed.2008.12.006. Epub 2009 Mar 6. PubMed PMID: 19269147.