Zinterol HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563548

CAS#: 38241-28-0

Description: Zinterol HCl is a potent and selective β2-adrenoceptor agonist.

Chemical Structure

Zinterol HCl
CAS# 38241-28-0

Theoretical Analysis

MedKoo Cat#: 563548
Name: Zinterol HCl
CAS#: 38241-28-0
Chemical Formula: C19H27ClN2O4S
Exact Mass: 414.138
Molecular Weight: 414.94
Elemental Analysis: C, 55.00; H, 6.56; Cl, 8.54; N, 6.75; O, 15.42; S, 7.73

Price and Availability

Size Price Availability Quantity
5.0mg USD 290.0 2 Weeks
25.0mg USD 540.0 2 Weeks
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Synonym: Zinterol hydrochloride; Zinterol HCl;

IUPAC/Chemical Name: N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamide hydrochloride


InChi Code: InChI=1S/C19H26N2O4S.ClH/c1-19(2,12-14-7-5-4-6-8-14)20-13-18(23)15-9-10-17(22)16(11-15)21-26(3,24)25;/h4-11,18,20-23H,12-13H2,1-3H3;1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 414.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Rozier K, Bondarenko VE. Mathematical modeling physiological effects of the overexpression of β(2)-adrenoceptors in mouse ventricular myocytes. Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H643-H658. doi: 10.1152/ajpheart.00160.2017. Epub 2017 Nov 3. PubMed PMID: 29101164.

2: Pabbidi MR, Ji X, Maxwell JT, Mignery GA, Samarel AM, Lipsius SL. Inhibition of cAMP-Dependent PKA Activates β2-Adrenergic Receptor Stimulation of Cytosolic Phospholipase A2 via Raf-1/MEK/ERK and IP3-Dependent Ca2+ Signaling in Atrial Myocytes. PLoS One. 2016 Dec 15;11(12):e0168505. doi: 10.1371/journal.pone.0168505. eCollection 2016. PubMed PMID: 27977772; PubMed Central PMCID: PMC5158063.

3: Sysa-Shah P, Tocchetti CG, Gupta M, Rainer PP, Shen X, Kang BH, Belmonte F, Li J, Xu Y, Guo X, Bedja D, Gao WD, Paolocci N, Rath R, Sawyer DB, Naga Prasad SV, Gabrielson K. Bidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways. Cardiovasc Res. 2016 Mar 1;109(3):358-73. doi: 10.1093/cvr/cvv274. Epub 2015 Dec 21. PubMed PMID: 26692570; PubMed Central PMCID: PMC4752042.

4: Li T, Cao J, Li Z, Wang X, He P. Broad screening and identification of β-agonists in feed and animal body fluid and tissues using ultra-high performance liquid chromatography-quadrupole-orbitrap high resolution mass spectrometry combined with spectra library search. Food Chem. 2016 Feb 1;192:188-96. doi: 10.1016/j.foodchem.2015.06.104. Epub 2015 Jun 30. PubMed PMID: 26304337.

5: Oliveira ES, Pereira AH, Cardoso AC, Franchini KG, Bassani JW, Bassani RA. Atrial chronotropic reactivity to catecholamines in neonatal rats: Contribution of β-adrenoceptor subtypes. Eur J Pharmacol. 2015 Oct 5;764:385-94. doi: 10.1016/j.ejphar.2015.07.031. Epub 2015 Jul 14. PubMed PMID: 26187314.

6: Regiart M, Escudero LA, Aranda P, Martinez NA, Bertolino FA, Raba J. Copper nanoparticles applied to the preconcentration and electrochemical determination of β-adrenergic agonist: an efficient tool for the control of meat production. Talanta. 2015 Apr;135:138-44. doi: 10.1016/j.talanta.2014.12.026. Epub 2014 Dec 30. PubMed PMID: 25640137.

7: Bond RC, Choisy SC, Bryant SM, Hancox JC, James AF. Inhibition of a TREK-like K+ channel current by noradrenaline requires both β1- and β2-adrenoceptors in rat atrial myocytes. Cardiovasc Res. 2014 Oct 1;104(1):206-15. doi: 10.1093/cvr/cvu192. Epub 2014 Sep 9. PubMed PMID: 25205295; PubMed Central PMCID: PMC4174890.

8: Gibbs M. Reflections on glycogen and β-amyloid: why does glycogenolytic β2-adrenoceptor stimulation not rescue memory after β-amyloid? Metab Brain Dis. 2015 Feb;30(1):345-52. doi: 10.1007/s11011-014-9563-y. Epub 2014 May 9. Review. PubMed PMID: 24810634.

9: Bryant S, Kimura TE, Kong CH, Watson JJ, Chase A, Suleiman MS, James AF, Orchard CH. Stimulation of ICa by basal PKA activity is facilitated by caveolin-3 in cardiac ventricular myocytes. J Mol Cell Cardiol. 2014 Mar;68:47-55. doi: 10.1016/j.yjmcc.2013.12.026. Epub 2014 Jan 9. PubMed PMID: 24412535; PubMed Central PMCID: PMC3980375.

10: Gibbs ME, Hutchinson DS. Rapid turnover of glycogen in memory formation. Neurochem Res. 2012 Nov;37(11):2456-63. doi: 10.1007/s11064-012-0805-2. Epub 2012 Jun 5. PubMed PMID: 22664636.

11: Macdougall DA, Agarwal SR, Stopford EA, Chu H, Collins JA, Longster AL, Colyer J, Harvey RD, Calaghan S. Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte. J Mol Cell Cardiol. 2012 Feb;52(2):388-400. doi: 10.1016/j.yjmcc.2011.06.014. Epub 2011 Jun 26. PubMed PMID: 21740911; PubMed Central PMCID: PMC3270222.

12: Pabbidi MR, Ji X, Samarel AM, Lipsius SL. Laminin enhances beta(2)-adrenergic receptor stimulation of L-type Ca(2+) current via cytosolic phospholipase A(2) signalling in cat atrial myocytes. J Physiol. 2009 Oct 15;587(Pt 20):4785-97. doi: 10.1113/jphysiol.2009.179226. Epub 2009 Aug 24. PubMed PMID: 19703961; PubMed Central PMCID: PMC2770147.

13: Sato M, Hutchinson DS, Evans BA, Summers RJ. The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)prop yl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl] benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor. Mol Pharmacol. 2008 Nov;74(5):1417-28. doi: 10.1124/mol.108.046979. Epub 2008 Aug 6. PubMed PMID: 18684840.

14: Hutchinson DS, Summers RJ, Gibbs ME. Energy metabolism and memory processing: role of glucose transport and glycogen in responses to adrenoceptor activation in the chicken. Brain Res Bull. 2008 Jun 15;76(3):224-34. doi: 10.1016/j.brainresbull.2008.02.019. Epub 2008 Mar 6. Review. PubMed PMID: 18498935.

15: Desantiago J, Ai X, Islam M, Acuna G, Ziolo MT, Bers DM, Pogwizd SM. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 6;102(11):1389-97. doi: 10.1161/CIRCRESAHA.107.169011. Epub 2008 May 8. PubMed PMID: 18467626; PubMed Central PMCID: PMC2585979.

16: McConville P, Lakatta EG, Spencer RG. Greater glycogen utilization during 1- than 2-adrenergic receptor stimulation in the isolated perfused rat heart. Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1828-35. Epub 2007 Oct 2. PubMed PMID: 17911346.

17: Collis LP, Srivastava S, Coetzee WA, Artman M. beta2-Adrenergic receptor agonists stimulate L-type calcium current independent of PKA in newborn rabbit ventricular myocytes. Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H2826-35. Epub 2007 Aug 24. PubMed PMID: 17720773.

18: Hutchinson DS, Summers RJ, Gibbs ME. Beta2- and beta3-adrenoceptors activate glucose uptake in chick astrocytes by distinct mechanisms: a mechanism for memory enhancement? J Neurochem. 2007 Nov;103(3):997-1008. Epub 2007 Aug 6. PubMed PMID: 17680985.

19: Molenaar P, Savarimuthu SM, Sarsero D, Chen L, Semmler AB, Carle A, Yang I, Bartel S, Vetter D, Beyerdörfer I, Krause EG, Kaumann AJ. (-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta2 -adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling. Naunyn Schmiedebergs Arch Pharmacol. 2007 Mar;375(1):11-28. Epub 2007 Feb 13. PubMed PMID: 17295024.

20: Hutchinson DS, Chernogubova E, Sato M, Summers RJ, Bengtsson T. Agonist effects of zinterol at the mouse and human beta(3)-adrenoceptor. Naunyn Schmiedebergs Arch Pharmacol. 2006 May;373(2):158-68. Epub 2006 Apr 7. PubMed PMID: 16601951.