WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 563537
CAS#: 924298-51-1
Description: ABP688 is a potent human mGlu5 receptor antagonist.
MedKoo Cat#: 563537
Name: ABP688
CAS#: 924298-51-1
Chemical Formula: C15H16N2O
Exact Mass: 240.1263
Molecular Weight: 240.3
Elemental Analysis: C, 74.97; H, 6.71; N, 11.66; O, 6.66
Synonym: ABP688; ABP-688; ABP 688;
IUPAC/Chemical Name: 3-[2-(6-Methyl-2-pyridinyl)ethynyl]-2-cyclohexene-1-one O-methyloxime
InChi Key: CNNZLFXCUQLKOB-BMRADRMJSA-N
InChi Code: InChI=1S/C15H16N2O/c1-12-5-3-7-14(16-12)10-9-13-6-4-8-15(11-13)17-18-2/h3,5,7,11H,4,6,8H2,1-2H3/b17-15+
SMILES Code: CC1=CC=CC(C#CC(CCC/2)=CC2=N\OC)=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 240.3 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Leung K. (E)-3-(Pyridin-2-ylethynyl)-cyclohex-2-enone-O-2-(2-[(18)F]fluoroethoxy)ethyl oxime. 2011 Jun 5 [updated 2011 Sep 29]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from http://www.ncbi.nlm.nih.gov/books/NBK63866/ PubMed PMID: 21977531.
2: Cheng KT. 3-(6-Methyl-pyridin-2-ylethynyl)-cyclohex-2-enone-O-(11)C-methyl-oxime . 2006 Apr 27 [updated 2008 Apr 28]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from http://www.ncbi.nlm.nih.gov/books/NBK23687/ PubMed PMID: 20641882.
3: Leung K. 3-(Pyridin-2-ylethynyl)-cyclohex-2-enone-O-[(18)F]fluoroethyl-oxime. 2007 Dec 3 [updated 2008 Jan 28]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from http://www.ncbi.nlm.nih.gov/books/NBK23648/ PubMed PMID: 20641843.
4: Nordquist RE, Steckler T, Wettstein JG, Mackie C, Spooren W. Metabotropic glutamate receptor modulation, translational methods, and biomarkers: relationships with anxiety. Psychopharmacology (Berl). 2008 Aug;199(3):389-402. doi: 10.1007/s00213-008-1096-9. Epub 2008 Mar 6. Review. PubMed PMID: 18322676.
