Altinicline

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592720

CAS#: 179120-92-4

Description: Altinicline binds to neuronal nicotinic acetylcholine receptors; SIB-1765F - fumarate.


Chemical Structure

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Altinicline
CAS# 179120-92-4

Theoretical Analysis

MedKoo Cat#: 592720
Name: Altinicline
CAS#: 179120-92-4
Chemical Formula: C12H14N2
Exact Mass: 186.1157
Molecular Weight: 186.258
Elemental Analysis: C, 77.38; H, 7.58; N, 15.04

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Altinicline

IUPAC/Chemical Name: Pyridine, 3-ethynyl-5-((2S)-1-methyl-2-pyrrolidinyl)-

InChi Key: NUPUDYKEEJNZRG-LBPRGKRZSA-N

InChi Code: InChI=1S/C12H14N2/c1-3-10-7-11(9-13-8-10)12-5-4-6-14(12)2/h1,7-9,12H,4-6H2,2H3/t12-/m0/s1

SMILES Code: CN1[C@H](C2=CN=CC(C#C)=C2)CCC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 186.258 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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Reconstitution Calculator

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1: Cosford ND, Bleicher L, Vernier JM, Chavez-Noriega L, Rao TS, Siegel RS, Suto C, Washburn M, Lloyd GK, McDonald IA. Recombinant human receptors and functional assays in the discovery of altinicline (SIB-1508Y), a novel acetylcholine-gated ion channel (nAChR) agonist. Pharm Acta Helv. 2000 Mar;74(2-3):125-30. PubMed PMID: 10812948.

2: Rao TS, Adams PB, Correa LD, Santori EM, Sacaan AI, Reid RT, Cosford ND. Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist. Brain Res. 2008 Oct 9;1234:16-24. doi: 10.1016/j.brainres.2008.07.063. Epub 2008 Jul 28. PubMed PMID: 18692487.

3: Wagner FF, Comins DL. Expedient five-step synthesis of SIB-1508Y from natural nicotine. J Org Chem. 2006 Oct 27;71(22):8673-5. PubMed PMID: 17064057.