WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 592704
Description: Alseroxylon is used in the treatment of hypertension.
MedKoo Cat#: 592704
Chemical Formula: C11H28ClN5O
Exact Mass: 281.1982
Molecular Weight: 281.83
Elemental Analysis: C, 46.88; H, 10.01; Cl, 12.58; N, 24.85; O, 5.68
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Alseroxylon; Egalin
IUPAC/Chemical Name: N1-(2-aminoethyl)-N2-(2-((2-aminoethyl)amino)ethyl)ethane-1,2-diamine compound with 2-(chloromethyl)oxirane (1:1)
InChi Key: GMRWGQCZJGVHKL-UHFFFAOYSA-N
InChi Code: InChI=1S/C8H23N5.C3H5ClO/c9-1-3-11-5-7-13-8-6-12-4-2-10;4-1-3-2-5-3/h11-13H,1-10H2;3H,1-2H2
SMILES Code: NCCNCCNCCNCCN.ClCC1CO1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 281.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: BENEDIG A, HOLLAND MH. Alseroxylon in neurodermatoses. Med Times. 1959 Apr;87(4):505-7. PubMed PMID: 13643249.
2: FERRARA RJ, PINKUS H. Alseroxylon in the treatment of pruritic and psychogenic dermatoses. AMA Arch Derm. 1955 Jul;72(1):23-28. PubMed PMID: 14387290.
3: TERMAN LA. Alseroxylon (Rauwiloid) therapy in disturbed elderly patients. Ill Med J. 1957 Feb;111(2):67-9. PubMed PMID: 13405555.
4: MELLER RL. Reserpine and alseroxylon therapy in emotionally disturbed patients. J Lancet. 1955 Aug;75(8):339-42. PubMed PMID: 13242964.
5: WRIGHT WT Jr, POKORNY C, FOSTER TL. Alseroxylon; a study of the psychological effects of the drug. J Kans Med Soc. 1956 Jul;57(7):410-1. PubMed PMID: 13346166.
6: FORD RV, MOYER JH. Rauwolfia toxicity in the treatment of hypertension; comparative toxicity of reserpine and alseroxylon. Postgrad Med. 1958 Jan;23(1):41-8. PubMed PMID: 13505370.
7: SCHLAGEL CA, NELSON JW. Rauwolfia hypotension. II. Action of the alseroxylon alkaloids and epinephrine on the carotid pressoreceptors. J Am Pharm Assoc Am Pharm Assoc. 1957 Feb;46(2):103-9. PubMed PMID: 13438725.
8: DENNIS E, McCONN RG, FORD RV, HUGHES WM, BEAZLEY HL, MOYER JH. Treatment of hypertension; long-term results with alseroxylon (rauwiloid) alone and combined with hexamethonium administered orally. Postgrad Med. 1954 Oct;16(4):300-7. PubMed PMID: 13204243.
9: TUCHMAN H, CRUMPTON CW. A comparison of Rauwolfia serpentina compounds, crude root, alseroxylon derivative, and single alkaloid, in the treatment of hypertension. Am Heart J. 1955 May;49(5):742-50. PubMed PMID: 14376327.
10: GREEN RS, DAVOLOS D. A long-term study of the effect of crude Rauwolfia serpentina and of its alseroxylon fraction in patients with hypertension. Am J Med. 1956 May;20(5):760-73. PubMed PMID: 13313574.