Ornoprostil

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461407

CAS#: 70667-26-4

Description: Ornoprostil is a prostaglandin E1 analogue that acts as a mucosal protectant.


Chemical Structure

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Ornoprostil
CAS# 70667-26-4

Theoretical Analysis

MedKoo Cat#: 461407
Name: Ornoprostil
CAS#: 70667-26-4
Chemical Formula: C23H38O6
Exact Mass: 410.2668
Molecular Weight: 410.55
Elemental Analysis: C, 67.29; H, 9.33; O, 23.38

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Ornoprostil; Ronoprost; OU 1308; OU-1308; OU1308;

IUPAC/Chemical Name: methyl 7-((1R,2R,3R)-3-hydroxy-2-((3S,5S,E)-3-hydroxy-5-methylnon-1-en-1-yl)-5-oxocyclopentyl)-6-oxoheptanoate

InChi Key: BBRBUTFBTUFFBU-LHACABTQSA-N

InChi Code: InChI=1S/C23H38O6/c1-4-5-8-16(2)13-18(25)11-12-19-20(22(27)15-21(19)26)14-17(24)9-6-7-10-23(28)29-3/h11-12,16,18-21,25-26H,4-10,13-15H2,1-3H3/b12-11+/t16-,18+,19+,20+,21+/m0/s1

SMILES Code: O=C(OC)CCCCC(C[C@@H]1[C@@H](/C=C/[C@@H](O)C[C@@H](C)CCCC)[C@H](O)CC1=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 410.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Fujiyama N, Shitara Y, Horie T. The mechanism of the down-regulation of hepatic transporters in rats with indomethacin-induced intestinal injury. Dig Dis Sci. 2013 Jul;58(7):1891-8. doi: 10.1007/s10620-013-2587-z. Epub 2013 Feb 27. PubMed PMID: 23443493.

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6: Nakamura A, Yamatani T, Fujita T, Chiba T. Mechanism of inhibitory action of prostaglandins on the growth of human gastric carcinoma cell line KATO III. Gastroenterology. 1991 Oct;101(4):910-8. PubMed PMID: 1653751.

7: Okano H, Saeki S, Inui A, Kawai Y, Morimoto S, Ohmoto A, Nakashima T, Miyamoto M, Oh T, Takata A, et al. Effect of synthetic prostaglandin E1 analog (ornoprostil) on gastric emptying and pancreatic polypeptide release after solid-meal ingestion in man. Dig Dis Sci. 1991 Jan;36(1):47-51. PubMed PMID: 1985004.

8: Kobayashi K, Arakawa T, Higuchi K, Nakamura H. Gastric cytoprotection by ornoprostil, a PGE1 analogue, in human subjects. J Clin Gastroenterol. 1991;13 Suppl 1:S32-6. PubMed PMID: 1940194.

9: Tsukada H, Seino Y, Jo I, Tatsuta H, Ito K, Hashimoto A, Kotera T, Matsubayashi Y, Mori Y, Ito A, et al. [Prevention of alcohol-induced gastric mucosal injury by prostaglandin E-1]. Nihon Shokakibyo Gakkai Zasshi. 1990 Oct;87(10):2342-51. Japanese. PubMed PMID: 2250376.

10: Okabe S, Takeuchi K, Niida H, Takinami Y. Effects of TY-10957, a stable PGI2 derivative, on gastroduodenal lesions and secretory responses in the rat. Digestion. 1990;45(2):61-71. PubMed PMID: 2112498.

11: Fukuda T, Arakawa T, Torii Y, Nebiki H, Nakamura H, Kobayashi K. Roles of endogenous leukotrienes and prostaglandins in the healing of gastric ulcers induced by acetic acid in rats. Scand J Gastroenterol Suppl. 1989;162:2-5. PubMed PMID: 2556789.