Ormetoprim
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461397

CAS#: 6981-18-6

Description: Ormetoprim is an antibiotic approved for use in the United States to prevent the spread of disease in freshwater aquaculture.


Chemical Structure

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Ormetoprim
CAS# 6981-18-6

Theoretical Analysis

MedKoo Cat#: 461397
Name: Ormetoprim
CAS#: 6981-18-6
Chemical Formula: C14H18N4O2
Exact Mass: 274.143
Molecular Weight: 274.32
Elemental Analysis: C, 61.30; H, 6.61; N, 20.42; O, 11.66

Price and Availability

Size Price Availability Quantity
250.0mg USD 250.0 2 Weeks
1.0g USD 405.0 2 Weeks
5.0g USD 865.0 2 Weeks
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Synonym: Ormetoprim; Ro 5-9754; Ro-5-9754; Ro5-9754;

IUPAC/Chemical Name: 5-(4,5-dimethoxy-2-methylbenzyl)pyrimidine-2,4-diamine

InChi Key: KEEYRKYKLYARHO-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H18N4O2/c1-8-4-11(19-2)12(20-3)6-9(8)5-10-7-17-14(16)18-13(10)15/h4,6-7H,5H2,1-3H3,(H4,15,16,17,18)

SMILES Code: NC1=NC=C(CC2=CC(OC)=C(OC)C=C2C)C(N)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 274.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Guerard JJ, Chin YP. Photodegradation of ormetoprim in aquaculture and stream-derived dissolved organic matter. J Agric Food Chem. 2012 Oct 3;60(39):9801-6. doi: 10.1021/jf302564d. Epub 2012 Sep 24. PubMed PMID: 22950359.

2: Yang YJ, Liu XW, Li B, Li SH, Kong XJ, Qin Z, Li JY. Simultaneous determination of diaveridine, trimethoprim and ormetoprim in feed using high performance liquid chromatography tandem mass spectrometry. Food Chem. 2016 Dec 1;212:358-66. doi: 10.1016/j.foodchem.2016.05.184. Epub 2016 Jun 1. PubMed PMID: 27374543.

3: Davami A, Peterson RA, Jones WT, Ilardi RL. Compatibility of sulfadimethoxine and ormetoprim with lasalocid and monensin on performance of male broiler chickens. Poult Sci. 1987 Feb;66(2):373-5. PubMed PMID: 3588507.

4: Bakal RS, Bai SA, Stoskopf MK. Pharmacokinetics of sulfadimethoxine and ormetoprim in a 5:1 ratio following intraperitoneal and oral administration, in the hybrid striped bass (Morone chrysops x Morone saxitalis). J Vet Pharmacol Ther. 2004 Feb;27(1):1-6. PubMed PMID: 14995959.

5: Brown MP, Gronwall RR, Houston AE. Pharmacokinetics and body fluid and endometrial concentrations of ormetoprim-sulfadimethoxine in mares. Can J Vet Res. 1989 Jan;53(1):12-6. PubMed PMID: 2914221; PubMed Central PMCID: PMC1255505.

6: Vasilopulos RJ, Mackin A, Lavergne SN, Trepanier LA. Nephrotic syndrome associated with administration of sulfadimethoxine/ormetoprim in a dobermann. J Small Anim Pract. 2005 May;46(5):232-6. PubMed PMID: 15909446.

7: Blackwell TE, Werdin RE, Eisenmenger MC, FitzSimmons MA. Goitrogenic effects in offspring of swine fed sulfadimethoxine and ormetoprim in late gestation. J Am Vet Med Assoc. 1989 Feb 15;194(4):519-23. PubMed PMID: 2921200.

8: Dunbar MR, Foreyt WJ. Prevention of coccidiosis in domestic dogs and captive coyotes (Canis latrans) with sulfadimethoxine-ormetoprim combination. Am J Vet Res. 1985 Sep;46(9):1899-902. PubMed PMID: 4051296.

9: Biel-Zielińska A, Brzeziński J. [Neurochemical disorders in rats caused by combined action of Primor and thiram. I. Changes in catecholamine and serotonin levels in the brain, heart and adrenal glands of rats with acute poisoning]. Rocz Panstw Zakl Hig. 1991;42(2):195-203. Polish. Erratum in: Rocz Panstw Zakl Hig 1991;42(4):following 357. PubMed PMID: 1803448.

10: Kosoff RE, Chen CY, Wooster GA, Getchell RG, Clifford A, Craigmill AL, Bowser PR. Sulfadimethoxine and ormetoprim residues in three species of fish after oral dosing in feed. J Aquat Anim Health. 2007 Jun;19(2):109-15. doi: 10.1577/H06-038.1. PubMed PMID: 18201051.

11: Droy BF, Goodrich MS, Lech JJ, Kleinow KM. Bioavailability, disposition and pharmacokinetics of 14C-ormetoprim in rainbow trout (Salmo gairdneri). Xenobiotica. 1990 Feb;20(2):147-57. PubMed PMID: 2333711.

12: Abascal JF, Abella M, Marinetto E, Pascau J, Desco M. A Novel Prior- and Motion-Based Compressed Sensing Method for Small-Animal Respiratory Gated CT. PLoS One. 2016 Mar 9;11(3):e0149841. doi: 10.1371/journal.pone.0149841. eCollection 2016. PubMed PMID: 26959370; PubMed Central PMCID: PMC4784891.

13: Wilson WD, George LW, Baggot JD, Adamson PJ, Hietala SK, Mihalyi JE. Ormetoprim-sulfadimethoxine in cattle: pharmacokinetics, bioavailability, distribution to the tears, and in vitro activity against Moraxella bovis. Am J Vet Res. 1987 Mar;48(3):407-14. PubMed PMID: 3565896.

14: Tanabe A, Kondo Y, Toriumi T. [Effect of sulfamonomethoxine and ormetoprim on leucocytozoon infection in chickens]. Nihon Yakurigaku Zasshi. 1986 Mar;87(3):273-9. Japanese. PubMed PMID: 3086195.

15: Hasbullah, Itahana H, Uchida T, Inamoto T, Nakai Y, Ogimoto K. Medication of feedlot calves infected with Eimeria spp. by a combination of sulfamonomethoxine and ormetoprim. J Vet Med Sci. 1996 Feb;58(2):169-70. PubMed PMID: 8672590.

16: Potter RA, Burns BG, van de Riet JM, North DH, Darvesh R. Simultaneous determination of 17 sulfonamides and the potentiators ormetoprim and trimethoprim in salmon muscle by liquid chromatography with tandem mass spectrometry detection. J AOAC Int. 2007 Jan-Feb;90(1):343-8. PubMed PMID: 17373466.

17: Samuelsen OB, Ervik A, Wennevik V. Absorption, tissue distribution, metabolism and excretion of ormetoprim and sulphadimethoxine in Atlantic salmon (Salmo salar) after intravenous and oral administration of Romet. Xenobiotica. 1995 Nov;25(11):1169-80. PubMed PMID: 8592867.

18: Topic Popovic N, Babish JG, Bowser PR. Observational study of hepatic cytochrome P-450 protein expression and activity in summer flounder (Paralichtys dentatus) after combination ormetoprim-sulfadimethoxine treatment. Chemotherapy. 2007;53(5):313-5. Epub 2007 Aug 29. PubMed PMID: 17728539.

19: Lin SY, Jeng SL. Comparison of ion-pairing and ion-suppressing liquid chromatographic methods for the determination of pyrimethamine and ormetoprim in chicken feed. J Chromatogr Sci. 2002 Jul;40(6):331-6. PubMed PMID: 12137205.

20: Sanders SM, Srivastava P, Feng Y, Dane JH, Basile J, Barnett MO. Sorption of the veterinary antimicrobials sulfadimethoxine and ormetoprim in soil. J Environ Qual. 2008 Jun 23;37(4):1510-8. doi: 10.2134/jeq2007.0215. Print 2008 Jul-Aug. PubMed PMID: 18574183.

Ormetoprim

250.0mg / USD 250.0