WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 592665
CAS#: 64622-45-3
Description: Ibuprofen piconol is a Pyridyl ester of ibuprofen.
MedKoo Cat#: 592665
Name: Ibuprofen Piconol
CAS#: 64622-45-3
Chemical Formula: C19H23NO2
Exact Mass: 297.1729
Molecular Weight: 297.4
Elemental Analysis: C, 76.74; H, 7.80; N, 4.71; O, 10.76
Synonym: Ibuprofen piconol
IUPAC/Chemical Name: 2-Pyridylmethyl 2-(4-isobutylphenyl)propionate
InChi Key: ACEWLPOYLGNNHV-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H23NO2/c1-14(2)12-16-7-9-17(10-8-16)15(3)19(21)22-13-18-6-4-5-11-20-18/h4-11,14-15H,12-13H2,1-3H3
SMILES Code: CC(C1=CC=C(CC(C)C)C=C1)C(OCC2=NC=CC=C2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 297.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Christensen JM, Stalker D. Ibuprofen piconol hydrolysis in vitro in plasma, whole blood, and serum using different anticoagulants. J Pharm Sci. 1991 Jan;80(1):29-31. PubMed PMID: 2013845.
2: Kubo K, Shirai K, Akaeda T, Oguchi M. Contact dermatitis from ibuprofen piconol. Contact Dermatitis. 1988 Mar;18(3):188-9. PubMed PMID: 3365979.
3: Kimura T, Doi K. Spontaneous comedones on the skin of hairless descendants of Mexican hairless dogs. Exp Anim. 1996 Oct;45(4):377-84. PubMed PMID: 8902502.
4: Kaluzny BD, Bannow CA. High-performance liquid chromatographic determination of pimeprofen and its metabolite ibuprofen in sheep plasma and lymph. J Chromatogr. 1987 Feb 20;414(1):228-34. PubMed PMID: 3571388.
5: Inoue Y, Isobe M, Shiohara T, Hayashi H. Inhibitory activity of CX-659S, a novel diaminouracil derivative, against the rebound phenomenon following withdrawal of corticosteroid therapy for chronic contact hypersensitivity responses. Int Arch Allergy Immunol. 2003 Jun;131(2):143-52. PubMed PMID: 12811023.
