S3QEL-2 | CAS#890888-12-7 | signal modulator

S3QEL-2
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563484

CAS#: 890888-12-7

Description: S3QEL-2 is a modulator of the retrograde signaling. It acts by strongly mitigating the oxidative stress-induced apoptosis that limits the yield of functional ß-cells from intact islets.

Chemical Structure

S3QEL-2

CAS# 890888-12-7

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 563484
Name: S3QEL-2
CAS#: 890888-12-7
Chemical Formula: C19H25N5
Exact Mass: 323.21
Molecular Weight: 323.440
Elemental Analysis: C, 70.56; H, 7.79; N, 21.65

Price and Availability

Size	Price	Availability
5mg	USD 250	2 Weeks
10mg	USD 400	2 Weeks
25mg	USD 700	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: S3QEL-2; S3QEL 2; S3QEL2;

IUPAC/Chemical Name: 1-(3,4-dimethylphenyl)-N,N-dipropyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

InChi Key: MGIAJZSCNPODRR-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H25N5/c1-5-9-23(10-6-2)18-17-12-22-24(19(17)21-13-20-18)16-8-7-14(3)15(4)11-16/h7-8,11-13H,5-6,9-10H2,1-4H3

SMILES Code: CCCN(CCC)C1=C2C(N(C3=CC=C(C)C(C)=C3)N=C2)=NC=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMF

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:

Product Data

Instruction:

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Biological target:	S3QEL-2 inhibits site IIIQo superoxide production (IC50 = 1.7 µM) without altering normal bioenergetics function. It reduced the production of H2O2 during oxidation of glutamate plus malate to 25% of the control level. S3QEL-2 also protects against ROS-induced cell stress in pancreatic β-cells and decreases HIF-1α induction in response to hypoxia.
In vitro activity:	S3QEL-2 was able to protect pancreatic β-cells during isolation and culture. S3QEL-2 enhanced both survival and function of primary pancreatic islets compared with equimolar amounts of EUK-134. S3QEL-2 is a cell-permeant, potent inhibitor of retrograde signaling mediated by superoxide from site IIIQo. Reference: Nat Chem Biol. 2015 Nov;11(11):834-6. https://pubmed.ncbi.nlm.nih.gov/26368590/
In vivo activity:	To be determined

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMF	10.0	30.92

Preparing Stock Solutions

The following data is based on the product molecular weight 323.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RL, Perevoshchikova IV, Petrassi HM, Meeusen SL, Ainscow EK, Brand MD. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015 Nov;11(11):834-6. doi: 10.1038/nchembio.1910. Epub 2015 Sep 14. PMID: 26368590; PMCID: PMC4618194.
In vitro protocol:	1. Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RL, Perevoshchikova IV, Petrassi HM, Meeusen SL, Ainscow EK, Brand MD. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015 Nov;11(11):834-6. doi: 10.1038/nchembio.1910. Epub 2015 Sep 14. PMID: 26368590; PMCID: PMC4618194.
In vivo protocol:	To be determined

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1: Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RL, Perevoshchikova IV, Petrassi HM, Meeusen SL, Ainscow EK, Brand MD. Suppressors of superoxide production from mitochondrial complex III. Nat Chem Biol. 2015 Nov;11(11):834-6. doi: 10.1038/nchembio.1910. Epub 2015 Sep 14. PubMed PMID: 26368590; PubMed Central PMCID: PMC4618194.

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