Neomyosuppressin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598669

CAS#: 143458-86-0

Description: Neomyosuppressin is a myoinhibiting neuropeptide from the grey fleshfly, Neobellieria bullata & Drosophila.

Chemical Structure

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Neomyosuppressin
CAS# 143458-86-0
Instruction

Theoretical Analysis

MedKoo Cat#: 598669
Name: Neomyosuppressin
CAS#: 143458-86-0
Chemical Formula: C58H86N16O15
Exact Mass: 1,246.65
Molecular Weight: 1,247.420
Elemental Analysis: C, 55.85; H, 6.95; N, 17.97; O, 19.24

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Neomyosuppressin; Neb-MS; Dromyosuppressin; Thr-asp-val-asp-his-val-phe-leu-arg-phenh2;

IUPAC/Chemical Name: (6S,9S,12S,15S,18S,21S,24S,27S)-18-((1H-imidazol-4-yl)methyl)-1-amino-6-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-27-((2S,3R)-2-amino-3-hydroxybutanamido)-12-benzyl-21-(carboxymethyl)-1-imino-9-isobutyl-15,24-diisopropyl-8,11,14,17,20,23,26-heptaoxo-2,7,10,13,16,19,22,25-octaazanonacosan-29-oic acid

InChi Key: XYBRAEZMEMTADX-XESIXFTMSA-N

InChi Code: InChI=1S/C58H86N16O15/c1-29(2)21-38(50(82)66-36(19-14-20-64-58(61)62)49(81)67-37(48(60)80)22-33-15-10-8-11-16-33)68-51(83)39(23-34-17-12-9-13-18-34)71-56(88)46(30(3)4)73-53(85)40(24-35-27-63-28-65-35)69-52(84)41(25-43(76)77)72-57(89)47(31(5)6)74-54(86)42(26-44(78)79)70-55(87)45(59)32(7)75/h8-13,15-18,27-32,36-42,45-47,75H,14,19-26,59H2,1-7H3,(H2,60,80)(H,63,65)(H,66,82)(H,67,81)(H,68,83)(H,69,84)(H,70,87)(H,71,88)(H,72,89)(H,73,85)(H,74,86)(H,76,77)(H,78,79)(H4,61,62,64)/t32-,36+,37+,38+,39+,40+,41+,42+,45+,46+,47+/m1/s1

SMILES Code: O=C(N)[C@H](CC1=CC=CC=C1)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CC2=CC=CC=C2)NC([C@H](C(C)C)NC([C@H](CC3=CNC=N3)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)N)=O)=O)=O)=O)=O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,247.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fónagy A, Schoofs L, Proost P, Van Damme J, Bueds H, De Loof A. Isolation, primary structure and synthesis of neomyosuppressin, a myoinhibiting neuropeptide from the grey fleshfly, Neobellieria bullata. Comp Biochem Physiol C. 1992 Jun;102(2):239-45. PubMed PMID: 1358537.

2: McCormick J, Nichols R. Spatial and temporal expression identify dromyosuppressin as a brain-gut peptide in Drosophila melanogaster. J Comp Neurol. 1993 Dec 8;338(2):278-88. PubMed PMID: 8308172.

3: Heifetz Y, Lindner M, Garini Y, Wolfner MF. Mating regulates neuromodulator ensembles at nerve termini innervating the Drosophila reproductive tract. Curr Biol. 2014 Mar 31;24(7):731-7. doi: 10.1016/j.cub.2014.02.042. Epub 2014 Mar 13. PubMed PMID: 24631240; PubMed Central PMCID: PMC4020355.

4: Bass C, Katanski C, Maynard B, Zurro I, Mariane E, Matta M, Loi M, Melis V, Capponi V, Muroni P, Setzu M, Nichols R. Conserved residues in RF-NH₂ receptor models identify predicted contact sites in ligand-receptor binding. Peptides. 2014 Mar;53:278-85. doi: 10.1016/j.peptides.2013.06.009. Epub 2013 Jun 26. PubMed PMID: 23811075.

5: Kiss B, Szlanka T, Zvara Á, Žurovec M, Sery M, Kakaš Š, Ramasz B, Hegedűs Z, Lukacsovich T, Puskás L, Fónagy A, Kiss I. Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster. Gen Comp Endocrinol. 2013 Sep 15;191:137-45. doi: 10.1016/j.ygcen.2013.05.023. Epub 2013 Jun 11. PubMed PMID: 23770020.

6: Nichols R, McCormick J, Lim I. Dromyosuppressin and drosulfakinin, two structurally related Drosophila neuropeptides, are uniquely expressed in the adult central nervous system. Ann N Y Acad Sci. 1997 Apr 24;814:315-8. PubMed PMID: 9160985.

7: Klose MK, Dason JS, Atwood HL, Boulianne GL, Mercier AJ. Peptide-induced modulation of synaptic transmission and escape response in Drosophila requires two G-protein-coupled receptors. J Neurosci. 2010 Nov 3;30(44):14724-34. doi: 10.1523/JNEUROSCI.3612-10.2010. PubMed PMID: 21048131.

8: Nichols R. Signaling pathways and physiological functions of Drosophila melanogaster FMRFamide-related peptides. Annu Rev Entomol. 2003;48:485-503. Epub 2002 Jun 4. Review. PubMed PMID: 12414735.

9: Kaminski S, Orlowski E, Berry K, Nichols R. The effects of three Drosophila melanogaster myotropins on the frequency of foregut contractions differ. J Neurogenet. 2002 Apr-Jun;16(2):125-34. PubMed PMID: 12479379.

10: Meola SM, Wright MS, Nichols R, Pendleton MW. Localization of myosuppressinlike peptides in the hypocerebral ganglion of two blood-feeding flies: horn fly and stable fly (Diptera:Muscidae). J Med Entomol. 1996 May;33(3):473-81. PubMed PMID: 8667397.

11: Nichols R, Bendena WG, Tobe SS. Myotropic peptides in Drosophila melanogaster and the genes that encode them. J Neurogenet. 2002 Jan-Mar;16(1):1-28. Review. PubMed PMID: 12420787.

12: Johnson EC, Bohn LM, Barak LS, Birse RT, Nässel DR, Caron MG, Taghert PH. Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions. J Biol Chem. 2003 Dec 26;278(52):52172-8. Epub 2003 Oct 10. PubMed PMID: 14555656.

13: Angioy AM, Muroni P, Barbarossa IT, McCormick J, Nichols R. Evidence dromyosuppressin acts at posterior and anterior pacemakers to decrease the fast and the slow cardiac activity in the blowfly Protophormia terraenovae. Peptides. 2007 Mar;28(3):585-93. Epub 2006 Dec 4. PubMed PMID: 17141921; PubMed Central PMCID: PMC3422744.

14: Richer S, Stoffolano JG Jr, Yin CM, Nichols R. Innervation of dromyosuppressin (DMS) immunoreactive processes and effect of DMS and benzethonium chloride on the Phormia regina (Meigen) crop. J Comp Neurol. 2000 May 22;421(1):136-42. PubMed PMID: 10813776.

15: Tibbetts MF, Nichols R. Immunocytochemistry of sequence-related neuropeptides in Drosophila. Neuropeptides. 1993 Jun;24(6):321-5. PubMed PMID: 8350979.