WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563466

CAS#: 1774353-12-6

Description: 6bK is an insulin degrading enzyme (IDE) inhibitor.

Chemical Structure

CAS# 1774353-12-6

Theoretical Analysis

MedKoo Cat#: 563466
Name: 6bK
CAS#: 1774353-12-6
Chemical Formula: C41H55N7O7
Exact Mass: 757.4163
Molecular Weight: 757.93
Elemental Analysis: C, 64.97; H, 7.31; N, 12.94; O, 14.78

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: 6bK; 6-bK; 6 bK; IDE-IN-6bK; IDE inhibitor 6bK; IDE-inhibitor-6bK;

IUPAC/Chemical Name: (3R,6S,9S,12E,16S)-9-(4-Aminobutyl)-3-[(4-benzoylphenyl)methyl]-6-(cyclohexylmethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,15-pentaazacycloeicos-12-ene-16-carboxamide


InChi Code: InChI=1S/C41H55N7O7/c42-23-9-7-16-32-40(54)48-34(25-27-11-3-1-4-12-27)41(55)47-33(26-28-17-19-30(20-18-28)37(51)29-13-5-2-6-14-29)39(53)44-24-10-8-15-31(38(43)52)45-35(49)21-22-36(50)46-32/h2,5-6,13-14,17-22,27,31-34H,1,3-4,7-12,15-16,23-26,42H2,(H2,43,52)(H,44,53)(H,45,49)(H,46,50)(H,47,55)(H,48,54)/b22-21+/t31-,32-,33+,34-/m0/s1

SMILES Code: O=C([C@H]1NC(/C=C/C(N[C@@H](CCCCN)C(N[C@@H](CC2CCCCC2)C(N[C@H](CC3=CC=C(C(C4=CC=CC=C4)=O)C=C3)C(NCCCC1)=O)=O)=O)=O)=O)N

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 757.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Hahn F, Schmalen A, Setz C, Friedrich M, Schlößer S, Kölle J, Spranger R, Rauch P, Fraedrich K, Reif T, Karius-Fischer J, Balasubramanyam A, Henklein P, Fossen T, Schubert U. Proteolysis of mature HIV-1 p6 Gag protein by the insulin-degrading enzyme (IDE) regulates virus replication in an Env-dependent manner. PLoS One. 2017 Apr 7;12(4):e0174254. doi: 10.1371/journal.pone.0174254. eCollection 2017. PubMed PMID: 28388673; PubMed Central PMCID: PMC5384750.

2: Bhattacharyya MR, Perkins-Porras L, Whitehead DL, Steptoe A. Psychological and clinical predictors of return to work after acute coronary syndrome. Eur Heart J. 2007 Jan;28(2):160-5. Epub 2006 Dec 21. PubMed PMID: 17185305.