WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592625

CAS#: 1111-39-3

Description: Acetyldigitoxin is a Cardioactive derivative of lanatoside A or of DIGITOXIN. It is used for fast digitalization in congestive heart failure.

Chemical Structure

CAS# 1111-39-3

Theoretical Analysis

MedKoo Cat#: 592625
Name: Acetyldigitoxin
CAS#: 1111-39-3
Chemical Formula: C43H66O14
Exact Mass: 806.45
Molecular Weight: 806.980
Elemental Analysis: C, 64.00; H, 8.24; O, 27.76

Price and Availability

Size Price Availability Quantity
1mg USD 400
Bulk inquiry

Related CAS #: 1111-39-3   25395-32-8,  

Synonym: Acylanide; Acetyldigitoxin

IUPAC/Chemical Name: (3beta,5beta)-3-((O-3-O-Acetyl-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy)-14-hydroxycard-20(22)-enolide


InChi Code: InChI=1S/C43H66O14/c1-21-38(48)33(54-24(4)44)19-37(51-21)57-40-23(3)53-36(18-32(40)46)56-39-22(2)52-35(17-31(39)45)55-27-9-12-41(5)26(16-27)7-8-30-29(41)10-13-42(6)28(11-14-43(30,42)49)25-15-34(47)50-20-25/h15,21-23,26-33,35-40,45-46,48-49H,7-14,16-20H2,1-6H3/t21-,22-,23-,26-,27+,28-,29+,30-,31+,32+,33+,35+,36+,37+,38-,39-,40-,41+,42-,43+/m1/s1

SMILES Code: C[C@H]1O[C@@H](O[C@H]2[C@H](C[C@@H](O[C@@H]2C)O[C@H]3[C@H](C[C@@H](O[C@@H]3C)O[C@H]4CC[C@]5([C@@H](C4)CC[C@@H]6[C@@H]5CC[C@@]7([C@@H](C8=CC(OC8)=O)CC[C@]67O)C)C)O)O)C[C@@H]([C@@H]1O)OC(C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 806.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Bodem G, Wirth K, Dengler HR. [Pharmacokinetic studies with alpha-acetyldigitoxin in man]. Verh Dtsch Ges Inn Med. 1974;80:1527-33. German. PubMed PMID: 4454473.

2: Hage DS, Sengupta A. Characterisation of the binding of digitoxin and acetyldigitoxin to human serum albumin by high-performance affinity chromatography. J Chromatogr B Biomed Sci Appl. 1999 Mar 5;724(1):91-100. PubMed PMID: 10202961.

3: TORMO ALFONSO V, BAGUENA CANDELA R. [Effect of acetyldigitoxin on the electrocardiogram]. Med Esp. 1958 Dec;40(237):504-16. Spanish. PubMed PMID: 13632285.

4: Belz GG, Nübling H, Strauch M. [Effect and plasma level of methylproscillaridin and beta-acetyldigitoxin following long term administration in man]. Verh Dtsch Ges Kreislaufforsch. 1975;41:315-9. German. PubMed PMID: 821263.

5: [Mechanism of action of acetyldigitoxin (acylanide) in various forms of arrhythmia]. Ned Tijdschr Geneeskd. 1957 Dec 7;101(49):2347-9. Dutch. PubMed PMID: 13504314.

6: Belova LF, Sokolov SIa, Arzamastsev EV, Alibekov SD, Mironova MI. [Pharmacological properties of adicin, Soviet alpha-acetyldigitoxin]. Farmakol Toksikol. 1980 Mar-Apr;43(2):170-7. Review. Russian. PubMed PMID: 7002595.

7: KING JC, LAADT JR. Acetyldigitoxin for cardiac decompensation in the elderly patient; a study of its effect in 33 ambulatory patients. Geriatrics. 1958 Feb;13(2):75-9. PubMed PMID: 13501427.

8: ARMAS CRUZ R, HARNECKER J, JALIL MUSSA J, MELEDA I. [Acetyldigitoxin, a new cardiotonic preparation]. Rev Med Chil. 1958 Jan;86(1):18-25. Spanish. PubMed PMID: 13542980.

9: VACCA JB, SCHUSTER JM, KNIGHT WA Jr. Clinical evaluation of acetyldigitoxin. Am J Cardiol. 1958 Jun;1(6):717-22. PubMed PMID: 13533294.

10: CASANOVA J. [A noteworthy medicine in cardiology: acetyldigitoxin]. Alger Medicale. 1955 Aug;59(8):517-9. French. PubMed PMID: 13275444.

11: LU FC, LAVALLEE A, ALLMARK MG, HOSSAIN MA. A comparative study on some pharmacological effects of digitoxin, acetyldigitoxin and gitalin (amorphous) in cats. J Pharm Pharmacol. 1958 Jun;10(6):375-9. PubMed PMID: 13550078.

12: SATOH D, OYAMA Y, OKUMURA T. Studies on digitalis glycoside; acetyldigitoxin-alpha from digitoxin. Pharm Bull. 1957 Dec;5(6):627. PubMed PMID: 13527160.

13: BROUSTET P, CASTAING R, BRICAUD H, COTTIN D. [Hemodynamic effects of acetyldigitoxin in mitral stenosis]. Arch Mal Coeur Vaiss. 1955 Sep;48(9):859-71. French. PubMed PMID: 13276061.

14: Bodem G, Wirth K, Dengler HJ. [Studies on metabolism and pharmacokinetics of alpha-acetyldigitoxin in man (author's transl)]. Arzneimittelforschung. 1975 Sep;25(9):1448-52. German. PubMed PMID: 1242671.

15: KAZMEIER F, LOHSE H, SCHILD W. [Clinical experiences with acetyldigitoxin (acylanid) treatment of heart insufficiency]. Arztl Wochensch. 1956 Mar 16;11(11):233-6. German. PubMed PMID: 13326735.

16: Tytman B. [Construction of author's table for the control of intravenous administration of acetyldigitoxin]. Pol Tyg Lek. 1979 Nov 26;34(48):1873-5. Polish. PubMed PMID: 530885.

17: DE SIMONE G, CINOTTI GA, MAGALINI S. [Spectrophotometric method for the determination of cardioactive glycosides. III. Calibration curve for acetyldigitoxin, lanatoside C and strophanthoside K]. Policlinico Med. 1956 Jun;63(3):133-6. Italian. PubMed PMID: 13349505.

18: SANAZARO PJ. Acetyldigitoxin in therapy of ambulatory patients with congestive heart failure. J Am Med Assoc. 1957 Jun 15;164(7):743-5. PubMed PMID: 13428547.

19: DAUPHIN G. [A new digitalic agent: acetyldigitoxin. Clinical study in 100 patients]. Arch Mal Coeur Vaiss. 1960 Jun;53:654-72. French. PubMed PMID: 13814227.

20: HUMERFELT SB, JORDE R. [Acetyldigitoxin; clinical evaluation]. Nord Med. 1958 Mar 6;59(10):351-3. Norwegian. PubMed PMID: 13517641.