Oxazidione

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598516

CAS#: 27591-42-0

Description: Oxazidione is an anticoagulant drug.

Chemical Structure

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Oxazidione
CAS# 27591-42-0
Instruction

Theoretical Analysis

MedKoo Cat#: 598516
Name: Oxazidione
CAS#: 27591-42-0
Chemical Formula: C20H19NO3
Exact Mass: 321.14
Molecular Weight: 321.370
Elemental Analysis: C, 74.75; H, 5.96; N, 4.36; O, 14.93

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Oxazidione; LD 4610; LD-4610; LD4610; Transidione; Amplidione;

IUPAC/Chemical Name: 2-(morpholinomethyl)-2-phenyl-1H-indene-1,3(2H)-dione

InChi Key: YYRYCTNXXHOENE-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H19NO3/c22-18-16-8-4-5-9-17(16)19(23)20(18,15-6-2-1-3-7-15)14-21-10-12-24-13-11-21/h1-9H,10-14H2

SMILES Code: O=C1C(C2=CC=CC=C2)(CN3CCOCC3)C(C4=C1C=CC=C4)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 321.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kim Y, Anderson MO, Park J, Lee MG, Namkung W, Verkman AS. Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP. Mol Pharmacol. 2015 Oct;88(4):689-96. doi: 10.1124/mol.115.098368. Epub 2015 Jul 14. PubMed PMID: 26174774; PubMed Central PMCID: PMC4576686.

2: Snyder DS, Tradtrantip L, Battula S, Yao C, Phuan PW, Fettinger JC, Kurth MJ, Verkman AS. ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27. ACS Med Chem Lett. 2013 May 9;4(5):456-459. PubMed PMID: 23814642; PubMed Central PMCID: PMC3694630.

3: Snyder DS, Tradtrantip L, Yao C, Kurth MJ, Verkman AS. Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. J Med Chem. 2011 Aug 11;54(15):5468-77. doi: 10.1021/jm200505e. Epub 2011 Jul 12. PubMed PMID: 21707078; PubMed Central PMCID: PMC3314378.

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5: FADIGA E, GESSI T, MAFFII G. [ELECTROPHYSIOLOGICAL RESEARCH ON THE ACTION OF AN OXAZINE-DIONE DERIVATIVE (DIETHADIONE) ON THE RESPIRATORY CENTERS]. Arch Sci Biol (Bologna). 1964 Apr-Jun;48:149-62. Italian. PubMed PMID: 14210398.

6: Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS. Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins. FASEB J. 2017 Feb;31(2):751-760. doi: 10.1096/fj.201600891R. Epub 2016 Nov 8. PubMed PMID: 27871064; PubMed Central PMCID: PMC5240666.