Ripretinib HCl

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MedKoo CAT#: 572146

CAS#: Ripretinib HCl

Description: Ripretinib, also known as DCC-2618, is a potent, orally active and selective KIT/PDGFR inhibitor with potential antineoplastic activity. DCC-2618 targets and binds to both wild-type and mutant forms of KIT and PDGFRa specifically at their switch pocket binding sites, thereby preventing the switch from inactive to active conformations of these kinases and inactivating their wild-type and mutant forms. In May 2020, FDA Approves Qinlock (ripretinib) for the Treatment of Fourth-Line Gastrointestinal Stromal Tumor


Chemical Structure

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Ripretinib HCl
CAS# Ripretinib HCl

Theoretical Analysis

MedKoo Cat#: 572146
Name: Ripretinib HCl
CAS#: Ripretinib HCl
Chemical Formula: C24H22BrClFN5O2
Exact Mass: 509.09
Molecular Weight: 546.825
Elemental Analysis: C, 52.72; H, 4.06; Br, 14.61; Cl, 6.48; F, 3.47; N, 12.81; O, 5.85

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1442472-39-0 (free base)   Ripretinib HCl   1225278-16-9 (wrong structure for DCC-2618)    

Synonym: Ripretinib HCl; Ripretinib hydrochloride; DCC-2618; DCC 2618; DCC2618; DP 2618; DP-2618; DP2618;

IUPAC/Chemical Name: N-{4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl]-2-fluorophenyl}-N'-phenylurea hydrochloride

InChi Key: SHMLAUSQLBFHPZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H21BrFN5O2.ClH/c1-3-31-21-12-22(27-2)28-13-14(21)9-17(23(31)32)16-10-20(19(26)11-18(16)25)30-24(33)29-15-7-5-4-6-8-15;/h4-13H,3H2,1-2H3,(H,27,28)(H2,29,30,33);1H

SMILES Code: O=C(NC1=CC=CC=C1)NC2=CC(C3=CC4=C(N(CC)C3=O)C=C(NC)N=C4)=C(Br)C=C2F.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 546.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Baird JH, Gotlib J. Clinical Validation of KIT Inhibition in Advanced Systemic
Mastocytosis. Curr Hematol Malig Rep. 2018 Oct;13(5):407-416. doi:
10.1007/s11899-018-0469-3. Review. PubMed PMID: 30155614.


2: Schneeweiss M, Peter B, Bibi S, Eisenwort G, Smiljkovic D, Blatt K, Jawhar M,
Berger D, Stefanzl G, Herndlhofer S, Greiner G, Hoermann G, Hadzijusufovic E,
Gleixner KV, Bettelheim P, Geissler K, Sperr WR, Reiter A, Arock M, Valent P. The
KIT and PDGFRA switch-control inhibitor DCC-2618 blocks growth and survival of
multiple neoplastic cell types in advanced mastocytosis. Haematologica. 2018
May;103(5):799-809. doi: 10.3324/haematol.2017.179895. Epub 2018 Feb 8. PubMed
PMID: 29439183; PubMed Central PMCID: PMC5927976.


3: BLU-285, DCC-2618 Show Activity against GIST. Cancer Discov. 2017
Feb;7(2):121-122. doi: 10.1158/2159-8290.CD-NB2016-165. Epub 2017 Jan 11. PubMed
PMID: 28077435.