WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 598507
CAS#: 107221-01-2
Description: Lactogangliotetraosylceramide is a leukemia-associated antigen having a novel branching structure.
MedKoo Cat#: 598507
Name: Lactogangliotetraosylceramide
CAS#: 107221-01-2
Chemical Formula: C70H129N3O23
Exact Mass: 1379.9017
Molecular Weight: 1380.8
Elemental Analysis: C, 60.89; H, 9.42; N, 3.04; O, 26.65
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Synonym: Lactogangliotetraosylceramide; LcGg4;
IUPAC/Chemical Name: N-((2R,3S,E)-1-(((2R,3S,4R,5R,6R)-5-(((2R,3R,4S,5S,6R)-4-(((2R,3R,4S,5S,6S)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5-(((2S,3S,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-hydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3,4-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-3-hydroxyoctadec-4-en-2-yl)tetracosanamide
InChi Key: YAVBLHXWKRSXJS-AUHMYXHSSA-N
InChi Code: InChI=1S/C70H129N3O23/c1-5-7-9-11-13-15-17-19-20-21-22-23-24-25-26-28-30-32-34-36-38-40-54(81)73-48(49(80)39-37-35-33-31-29-27-18-16-14-12-10-8-6-2)45-89-69-62(87)61(86)64(52(43-76)92-69)94-70-63(88)66(96-68-56(72-47(4)79)60(85)58(83)51(42-75)91-68)65(53(44-77)93-70)95-67-55(71-46(3)78)59(84)57(82)50(41-74)90-67/h37,39,48-53,55-70,74-77,80,82-88H,5-36,38,40-45H2,1-4H3,(H,71,78)(H,72,79)(H,73,81)/b39-37+/t48-,49+,50-,51+,52-,53-,55+,56-,57-,58-,59-,60+,61-,62+,63-,64+,65+,66+,67+,68-,69-,70-/m1/s1
SMILES Code: O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H]([C@H]([C@H](O[C@@H]2CO)O[C@@H]3[C@H](O)[C@H](O)[C@H](OC[C@H]([C@H](/C=C/CCCCCCCCCCCCC)O)NC(CCCCCCCCCCCCCCCCCCCCCCC)=O)O[C@@H]3CO)O)O[C@@H]4[C@H](NC(C)=O)[C@H](O)[C@H](O)[C@H](CO)O4)[C@@H](NC(C)=O)[C@H]1O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 1380.8 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Shigeta K, Ito Y, Ogawa T, Kirihata Y, Hakomori S, Kannagi R. Monoclonal antibodies directed to chemically synthesized lactogangliotetraosylceramide, a leukemia-associated antigen having a novel branching structure. J Biol Chem. 1987 Jan 25;262(3):1358-62. PubMed PMID: 3805024.
2: Levery SB, Holmes EH, Harris DD, Hakomori S. 1H NMR studies of a biosynthetic lacto-ganglio hybrid glycosphingolipid: confirmation of structure, interpretation of "anomalous" chemical shifts, and evidence for interresidue amide-amide hydrogen bonding. Biochemistry. 1992 Feb 4;31(4):1069-80. PubMed PMID: 1310419.
