Dalvastatin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461274

CAS#: 132100-55-1

Description: Dalvastatin is a prodrug which converts to its open hydroxyacid form in the body. It acts as a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.


Chemical Structure

img
Dalvastatin
CAS# 132100-55-1

Theoretical Analysis

MedKoo Cat#: 461274
Name: Dalvastatin
CAS#: 132100-55-1
Chemical Formula: C24H31FO3
Exact Mass: 386.2257
Molecular Weight: 386.5
Elemental Analysis: C, 74.58; H, 8.08; F, 4.92; O, 12.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Dalvastatin; RG 12561; RG-12561; RG12561;

IUPAC/Chemical Name: (4S,6R)-6-((E)-2-(4'-fluoro-3,3,3',5,5-pentamethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one

InChi Key: VDSBXXDKCUBMQC-VUOWKATKSA-N

InChi Code: InChI=1S/C24H31FO3/c1-15-10-16(6-9-21(15)25)19-13-23(2,3)14-24(4,5)20(19)8-7-18-11-17(26)12-22(27)28-18/h6-10,17-18,26H,11-14H2,1-5H3/b8-7+/t17-,18-/m0/s1

SMILES Code: O=C1C[C@@H](O)C[C@H](/C=C/C2=C(C3=CC=C(F)C(C)=C3)CC(C)(C)CC2(C)C)O1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 386.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Won CM. Epimerization and hydrolysis of dalvastatin, a new hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Pharm Res. 1994 Jan;11(1):165-70. PubMed PMID: 8140049.

2: Amin D, Gustafson SK, Weinacht JM, Cornell SA, Neuenschwander K, Kosmider B, Scotese AC, Regan JR, Perrone MH. RG 12561 (dalvastatin): a novel synthetic inhibitor of HMG-CoA reductase and cholesterol-lowering agent. Pharmacology. 1993;46(1):13-22. PubMed PMID: 8434028.

3: Khetarpal VK, Storbeck LS, Wells D, Meacham RH Jr. Method for separation and determination of lactone and hydroxy acid forms of a new HMG CoA reductase inhibitor (RG 12561) in plasma. J Chromatogr. 1991 Jul 5;567(2):491-7. PubMed PMID: 1939482.

4: Ammon HL, Prasad SM, Kumar N. Structure of RG-12561 dichloromethane solvate and a diastereomer. Acta Crystallogr C. 1992 Apr 15;48 ( Pt 4):669-75. PubMed PMID: 1515102.