WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 461274
Description: Dalvastatin is a prodrug which converts to its open hydroxyacid form in the body. It acts as a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
MedKoo Cat#: 461274
Chemical Formula: C24H31FO3
Exact Mass: 386.2257
Molecular Weight: 386.5
Elemental Analysis: C, 74.58; H, 8.08; F, 4.92; O, 12.42
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Dalvastatin; RG 12561; RG-12561; RG12561;
IUPAC/Chemical Name: (4S,6R)-6-((E)-2-(4'-fluoro-3,3,3',5,5-pentamethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)vinyl)-4-hydroxytetrahydro-2H-pyran-2-one
InChi Key: VDSBXXDKCUBMQC-VUOWKATKSA-N
InChi Code: InChI=1S/C24H31FO3/c1-15-10-16(6-9-21(15)25)19-13-23(2,3)14-24(4,5)20(19)8-7-18-11-17(26)12-22(27)28-18/h6-10,17-18,26H,11-14H2,1-5H3/b8-7+/t17-,18-/m0/s1
SMILES Code: O=C1C[C@@H](O)C[C@H](/C=C/C2=C(C3=CC=C(F)C(C)=C3)CC(C)(C)CC2(C)C)O1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 386.5 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Won CM. Epimerization and hydrolysis of dalvastatin, a new hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. Pharm Res. 1994 Jan;11(1):165-70. PubMed PMID: 8140049.
2: Amin D, Gustafson SK, Weinacht JM, Cornell SA, Neuenschwander K, Kosmider B, Scotese AC, Regan JR, Perrone MH. RG 12561 (dalvastatin): a novel synthetic inhibitor of HMG-CoA reductase and cholesterol-lowering agent. Pharmacology. 1993;46(1):13-22. PubMed PMID: 8434028.
3: Khetarpal VK, Storbeck LS, Wells D, Meacham RH Jr. Method for separation and determination of lactone and hydroxy acid forms of a new HMG CoA reductase inhibitor (RG 12561) in plasma. J Chromatogr. 1991 Jul 5;567(2):491-7. PubMed PMID: 1939482.
4: Ammon HL, Prasad SM, Kumar N. Structure of RG-12561 dichloromethane solvate and a diastereomer. Acta Crystallogr C. 1992 Apr 15;48 ( Pt 4):669-75. PubMed PMID: 1515102.