NAEPA
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MedKoo CAT#: 563432

CAS#: 24435-25-4

Description: NAEPA is a selective lysophosphatidic acid-1 (LPA1) receptor agonist and a LPA mimetic.


Chemical Structure

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NAEPA
CAS# 24435-25-4

Theoretical Analysis

MedKoo Cat#: 563432
Name: NAEPA
CAS#: 24435-25-4
Chemical Formula: C20H40NO5P
Exact Mass: 405.26
Molecular Weight: 405.510
Elemental Analysis: C, 59.24; H, 9.94; N, 3.45; O, 19.73; P, 7.64

Price and Availability

Size Price Availability Quantity
5mg USD 340 2 Weeks
10mg USD 560 2 Weeks
25mg USD 1015 2 Weeks
50mg USD 1575 2 Weeks
100mg USD 2550 2 Weeks
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Synonym: NAEPA;

IUPAC/Chemical Name: (Z)-N-[2-(Phosphonooxy)ethyl]-9-octadecenamide

InChi Key: BCSUWOZFWWBYSX-KTKRTIGZSA-N

InChi Code: InChI=1S/C20H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)21-18-19-26-27(23,24)25/h9-10H,2-8,11-19H2,1H3,(H,21,22)(H2,23,24,25)/b10-9-

SMILES Code: CCCCCCCC/C=C\CCCCCCCC(NCCOP(O)(O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 405.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Woclawek-Potocka I, Kondraciuk K, Skarzynski DJ. Lysophosphatidic acid stimulates prostaglandin E2 production in cultured stromal endometrial cells through LPA1 receptor. Exp Biol Med (Maywood). 2009 Aug;234(8):986-93. doi: 10.3181/0901-RM-36. Epub 2009 Jun 2. PubMed PMID: 19491366.

2: Sardar VM, Bautista DL, Fischer DJ, Yokoyama K, Nusser N, Virag T, Wang DA, Baker DL, Tigyi G, Parrill AL. Molecular basis for lysophosphatidic acid receptor antagonist selectivity. Biochim Biophys Acta. 2002 May 23;1582(1-3):309-17. Review. PubMed PMID: 12069842.

3: Yokoyama K, Baker DL, Virag T, Liliom K, Byun HS, Tigyi G, Bittman R. Stereochemical properties of lysophosphatidic acid receptor activation and metabolism. Biochim Biophys Acta. 2002 May 23;1582(1-3):295-308. Review. PubMed PMID: 12069841.

4: Lynch KR, Macdonald TL. Structure-activity relationships of lysophosphatidic acid analogs. Biochim Biophys Acta. 2002 May 23;1582(1-3):289-94. Review. PubMed PMID: 12069840.