NAEPA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563432

CAS#: 24435-25-4

Description: NAEPA is a selective lysophosphatidic acid-1 (LPA1) receptor agonist and a LPA mimetic.


Price and Availability

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NAEPA is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 563432
Name: NAEPA
CAS#: 24435-25-4
Chemical Formula: C20H40NO5P
Exact Mass: 405.2644
Molecular Weight: 405.51
Elemental Analysis: C, 59.24; H, 9.94; N, 3.45; O, 19.73; P, 7.64


Synonym: NAEPA;

IUPAC/Chemical Name: (Z)-N-[2-(Phosphonooxy)ethyl]-9-octadecenamide

InChi Key: BCSUWOZFWWBYSX-KTKRTIGZSA-N

InChi Code: InChI=1S/C20H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)21-18-19-26-27(23,24)25/h9-10H,2-8,11-19H2,1H3,(H,21,22)(H2,23,24,25)/b10-9-

SMILES Code: CCCCCCCC/C=C\CCCCCCCC(NCCOP(O)(O)=O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Woclawek-Potocka I, Kondraciuk K, Skarzynski DJ. Lysophosphatidic acid stimulates prostaglandin E2 production in cultured stromal endometrial cells through LPA1 receptor. Exp Biol Med (Maywood). 2009 Aug;234(8):986-93. doi: 10.3181/0901-RM-36. Epub 2009 Jun 2. PubMed PMID: 19491366.

2: Sardar VM, Bautista DL, Fischer DJ, Yokoyama K, Nusser N, Virag T, Wang DA, Baker DL, Tigyi G, Parrill AL. Molecular basis for lysophosphatidic acid receptor antagonist selectivity. Biochim Biophys Acta. 2002 May 23;1582(1-3):309-17. Review. PubMed PMID: 12069842.

3: Yokoyama K, Baker DL, Virag T, Liliom K, Byun HS, Tigyi G, Bittman R. Stereochemical properties of lysophosphatidic acid receptor activation and metabolism. Biochim Biophys Acta. 2002 May 23;1582(1-3):295-308. Review. PubMed PMID: 12069841.

4: Lynch KR, Macdonald TL. Structure-activity relationships of lysophosphatidic acid analogs. Biochim Biophys Acta. 2002 May 23;1582(1-3):289-94. Review. PubMed PMID: 12069840.