Muscimol HBr | CAS#18174-72-6 | GABAA receptor agonist

Muscimol HBr
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563431

CAS#: 18174-72-6

Description: Muscimol HBr is a GABAA receptor agonist.

Chemical Structure

Muscimol HBr

CAS# 18174-72-6

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 563431
Name: Muscimol HBr
CAS#: 18174-72-6
Chemical Formula: C4H7BrN2O2
Exact Mass: 0.00
Molecular Weight: 195.016
Elemental Analysis: C, 24.64; H, 3.62; Br, 40.97; N, 14.36; O, 16.41

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 290
10mg	USD 470
25mg	USD 820
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Muscimol Hydrobromide; Muscimol HBr; Agarin hydrobromide; Agarin HBr;

IUPAC/Chemical Name: 5-(aminomethyl)isoxazol-3(2H)-one hydrobromide

InChi Key: OPZOJWHOZRKYQX-UHFFFAOYSA-N

InChi Code: InChI=1S/C4H6N2O2.BrH/c5-2-3-1-4(7)6-8-3;/h1H,2,5H2,(H,6,7);1H

SMILES Code: O=C1NOC(CN)=C1.[H]Br

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Product Data:

Product Data

Instruction:

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Biological target:	Muscimol HBr is a GABAA receptor agonist.
In vitro activity:	The present study was performed to identify the effect of GABAR agonists on K2P channel expression and activity in the neuroblastic B35 cells that maintain glutamic acid decarboxylase (GAD) activity and express GABA. In particular, muscimol, a GABAAR agonist, significantly increased TREK-2 expression and activity, but the effect was reduced in the presence of the GABAAR antagonist bicuculine or TREK-2 inhibitor norfluoxetine. In the whole-cell and single-channel patch configurations, muscimol increased TREK-2 activity, but the muscimol effect disappeared in the N-terminal deletion mutant. Reference: Int J Mol Sci. 2021 Aug 27;22(17):9320. https://pubmed.ncbi.nlm.nih.gov/34502229/
In vivo activity:	This study hypothesized that muscimol, a selective GABA(A) agonist, could act on endogenous GABA(A) channels expressed on airway smooth muscle to attenuate induced increases in airway pressures in anesthetized guinea pigs in vivo. Pretreatment with intravenous muscimol alone attenuated intravenous histamine-, intravenous acetylcholine-, or vagal nerve-stimulated increases in peak pulmonary inflation pressure. Pretreatment with the GABA(A) antagonist gabazine blocked muscimol's effect. Reference: J Appl Physiol (1985). 2009 Apr;106(4):1257-63. https://pubmed.ncbi.nlm.nih.gov/19213928/

Preparing Stock Solutions

The following data is based on the product molecular weight 195.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Kim EJ, Kwon OS, Hur CG, Nyiramana MM, Lee DK, Hong SG, Han J, Kang D. Muscimol Directly Activates the TREK-2 Channel Expressed in GABAergic Neurons through Its N-Terminus. Int J Mol Sci. 2021 Aug 27;22(17):9320. doi: 10.3390/ijms22179320. PMID: 34502229; PMCID: PMC8431218. 2. Kanasaki H, Tumurbaatar T, Oride A, Hara T, Okada H, Kyo S. Gamma-aminobutyric acidA receptor agonist, muscimol, increases KiSS-1 gene expression in hypothalamic cell models. Reprod Med Biol. 2017 Oct 4;16(4):386-391. doi: 10.1002/rmb2.12061. PMID: 29259493; PMCID: PMC5715903. 3. Jafari-Sabet M, Jannat-Dastjerdi I. Muscimol state-dependent memory: involvement of dorsal hippocampal mu-opioid receptors. Behav Brain Res. 2009 Aug 24;202(1):5-10. doi: 10.1016/j.bbr.2009.03.010. Epub 2009 Mar 19. PMID: 19447274. 4. Gleason NR, Gallos G, Zhang Y, Emala CW. The GABAA agonist muscimol attenuates induced airway constriction in guinea pigs in vivo. J Appl Physiol (1985). 2009 Apr;106(4):1257-63. doi: 10.1152/japplphysiol.91314.2008. Epub 2009 Feb 12. PMID: 19213928; PMCID: PMC2698643.
In vitro protocol:	1. Kim EJ, Kwon OS, Hur CG, Nyiramana MM, Lee DK, Hong SG, Han J, Kang D. Muscimol Directly Activates the TREK-2 Channel Expressed in GABAergic Neurons through Its N-Terminus. Int J Mol Sci. 2021 Aug 27;22(17):9320. doi: 10.3390/ijms22179320. PMID: 34502229; PMCID: PMC8431218. 2. Kanasaki H, Tumurbaatar T, Oride A, Hara T, Okada H, Kyo S. Gamma-aminobutyric acidA receptor agonist, muscimol, increases KiSS-1 gene expression in hypothalamic cell models. Reprod Med Biol. 2017 Oct 4;16(4):386-391. doi: 10.1002/rmb2.12061. PMID: 29259493; PMCID: PMC5715903.
In vivo protocol:	1. Jafari-Sabet M, Jannat-Dastjerdi I. Muscimol state-dependent memory: involvement of dorsal hippocampal mu-opioid receptors. Behav Brain Res. 2009 Aug 24;202(1):5-10. doi: 10.1016/j.bbr.2009.03.010. Epub 2009 Mar 19. PMID: 19447274. 2. Gleason NR, Gallos G, Zhang Y, Emala CW. The GABAA agonist muscimol attenuates induced airway constriction in guinea pigs in vivo. J Appl Physiol (1985). 2009 Apr;106(4):1257-63. doi: 10.1152/japplphysiol.91314.2008. Epub 2009 Feb 12. PMID: 19213928; PMCID: PMC2698643.

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1: Jang IS, Nakamura M, Ito Y, Akaike N. Presynaptic GABAA receptors facilitate spontaneous glutamate release from presynaptic terminals on mechanically dissociated rat CA3 pyramidal neurons. Neuroscience. 2006;138(1):25-35. Epub 2005 Dec 27. PubMed PMID: 16378694.

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