Alfadolone | CAS#14107-37-0 | anesthetic

Alfadolone
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592531

CAS#: 14107-37-0

Description: Alfadolone is an anesthetic derivative of pregnanedione.

Chemical Structure

Alfadolone

CAS# 14107-37-0

Instruction

Theoretical Analysis

MedKoo Cat#: 592531
Name: Alfadolone
CAS#: 14107-37-0
Chemical Formula: C21H32O4
Exact Mass: 348.23
Molecular Weight: 348.483
Elemental Analysis: C, 72.38; H, 9.26; O, 18.36

Price and Availability

Size	Price	Availability
5mg	USD 395	2 Weeks
50mg	USD 2850	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Alfadolone

IUPAC/Chemical Name: 3alpha,21-Dihydroxy-5alpha-pregnane-11,20-dione

InChi Key: XWYBFXIUISNTQG-VKMGZQQJSA-N

InChi Code: InChI=1S/C21H32O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h12-16,19,22-23H,3-11H2,1-2H3/t12-,13+,14-,15-,16+,19+,20-,21-/m0/s1

SMILES Code: C[C@@]1(C2)[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CC[C@@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C2=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 348.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Fischer PW, Ferizovic A, Neilson IR, Marks GS. Porphyrin-inducing activity of alfaxolone and alfadolone acetate in chick embryo liver cells. Anesthesiology. 1979 Apr;50(4):350-2. PubMed PMID: 434539.

2: Baldy-Moulinier M, Besset-Lehmann J, Passouant P. [Effects of combination alfaxalone and alfadolone, anesthetic derivatives of pregnanedione, on cerebral hemodynamics in cats]. C R Seances Soc Biol Fil. 1975;169(1):126-31. French. PubMed PMID: 126719.

3: Jungck E, Klöss T, Blendl M, Hoerster W, Klaucke D. [Experiences with the steroid narcotic alfaxalone/alfadolone (Aurantex) in emergency patients in rescue service]. Anasth Intensivther Notfallmed. 1983 Feb;18(1):8-13. German. PubMed PMID: 6846760.

4: Ramsay MA, Savege TM, Simpson BR, Goodwin R. Controlled sedation with alphaxalone-alphadolone. Br Med J. 1974 Jun 22;2(5920):656-9. PubMed PMID: 4835444; PubMed Central PMCID: PMC1613102.

5: Brown TC. Thiopentone and its challengers. Paediatr Anaesth. 2013 Oct;23(10):957-8. doi: 10.1111/pan.12083. Epub 2012 Dec 6. PubMed PMID: 23216953.

6: Tachon P, Descotes J, Laschi-Loquerie A, Guillot JP, Evreux JC. Assessment of the allergenic potential of althesin and its constituents. Br J Anaesth. 1983 Aug;55(8):715-7. PubMed PMID: 6882610.

7: Ruane-O'Hora T, Hall WJ, Markos F. The effect of alphaxalone-alphadolone, propofol, and pentobarbitone anaesthesia on the β-endorphin and ACTH response to haemorrhage in the pig. Can J Physiol Pharmacol. 2011 Jul;89(7):521-6. doi: 10.1139/Y11-035. PubMed PMID: 21812530.

8: Sear JW. Steroid anesthetics: old compounds, new drugs. J Clin Anesth. 1996 May;8(3 Suppl):91S-98S. Review. PubMed PMID: 8695125.

9: McIlhany M, Rapport R, Dunn R, Namazie M, Delilikan A. Althesin in the management of head injuries: a preliminary report. Neurosurgery. 1983 Jan;12(1):77-9. PubMed PMID: 6828225.

10: al-Khawashki MI, Ghaleb HA, el-Gawhery N, Madkour MK, Radwan AM, el-Sherbiny AM. Pharmacological studies on the effects of althesin and its steroidal components on the cardiovascular system. J Egypt Med Assoc. 1979;62(1-2):225-39. PubMed PMID: 122257.

11: Bailey TA, Toosi A, Samour JH. Anaesthesia of cranes with alphaxolone-alphadolone. Vet Rec. 1999 Jul 17;145(3):84-5. PubMed PMID: 10460033.

12: Lawrence K, Jackson OF. Alphaxalone/alphadolone anaesthesia in reptiles. Vet Rec. 1983 Jan 8;112(2):26-8. PubMed PMID: 6829138.

13: Peterson SL. Anticonvulsant profile of an anesthetic steroid. Neuropharmacology. 1989 Aug;28(8):877-9. PubMed PMID: 2779755.

14: Cox JE, Done SH, Lees P, Walton JR. Preliminary studies of the actions of alphaxalone and alphadolone in the pig. Vet Rec. 1975 Dec 20-27;97(25-26):497-8. PubMed PMID: 1202746.

15: Samour JH, Jones DM, Knight JA, Howlett JC. Comparative studies of the use of some injectable anaesthetic agents in birds. Vet Rec. 1984 Jul 7;115(1):6-11. PubMed PMID: 6464345.

16: Gibbons RW. Anaesthesia of kids with alphaxalone/alphadolone. Vet Rec. 1986 Sep 27;119(13):339. PubMed PMID: 3776047.

17: Colantuoni A, Bertuglia S, Intaglietta M. Effects of anesthesia on the spontaneous activity of the microvasculature. Int J Microcirc Clin Exp. 1984;3(1):13-28. PubMed PMID: 6480227.

18: Hale GJ. Respiratory obstruction after anaesthesia. Vet Rec. 1989 Aug 19;125(8):211-2. PubMed PMID: 2624630.

19: Eales FA, Small J. Alphaxalone/alphadolone anaesthesia in the lamb. Vet Rec. 1982 Mar 20;110(12):273-5. PubMed PMID: 7080417.

20: Holly JM, Trafford DJ, Sear JW, Makin HL. The in vivo metabolism of Althesin (alphaxalone + alphadolone acetate) in man. J Pharm Pharmacol. 1981 Jul;33(7):427-33. PubMed PMID: 6115029.

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