Maneb
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461211

CAS#: 12427-38-2

Description: Maneb is an fungicide widely used to control fungal diseases on crops, fruits, and vegetables.

Chemical Structure

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Maneb
CAS# 12427-38-2
Instruction

Theoretical Analysis

MedKoo Cat#: 461211
Name: Maneb
CAS#: 12427-38-2
Chemical Formula: C4H6MnN2S4
Exact Mass: 264.88
Molecular Weight: 265.280
Elemental Analysis: C, 18.11; H, 2.28; Mn, 20.71; N, 10.56; S, 48.34

Price and Availability

Size Price Availability Quantity
250mg USD 350 2 weeks
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Synonym: Maneb; CR 3029; CR-3029; CR3029; F 10; F-10; F10; Farmaneb; Rhodianebe; Sopranebe; Tubothane;

IUPAC/Chemical Name: manganese(II) ethane-1,2-diyldicarbamodithioate

InChi Key: YKSNLCVSTHTHJA-UHFFFAOYSA-L

InChi Code: InChI=1S/C4H8N2S4.Mn/c7-3(8)5-1-2-6-4(9)10;/h1-2H2,(H2,5,7,8)(H2,6,9,10);/q;+2/p-2

SMILES Code: [S-]C(NCCNC([S-])=S)=S.[Mn+2]

Appearance: Solid powder

Purity: >90% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 265.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Gürkan M, Hayretdağ S. Acute toxicity of maneb in the tadpoles of common and green toad. Arh Hig Rada Toksikol. 2015 Sep 1;66(3):189-95. doi: 10.1515/aiht-2015-66-2642. PubMed PMID: 26444339.

2: Manfo FP, Nantia EA, Dechaud H, Tchana AN, Zabot MT, Pugeat M, Moundipa PF. Protective effect of Basella alba and Carpolobia alba extracts against maneb-induced male infertility. Pharm Biol. 2014 Jan;52(1):97-104. doi: 10.3109/13880209.2013.816860. Epub 2013 Sep 30. PubMed PMID: 24073857.

3: Ahmad I, Shukla S, Singh D, Chauhan AK, Kumar V, Singh BK, Patel DK, Pandey HP, Singh C. CYP2E1-mediated oxidative stress regulates HO-1 and GST expression in maneb- and paraquat-treated rat polymorphonuclear leukocytes. Mol Cell Biochem. 2014 Aug;393(1-2):209-22. doi: 10.1007/s11010-014-2062-y. Epub 2014 Apr 27. PubMed PMID: 24771067.

4: Roede JR, Jones DP. Thiol-reactivity of the fungicide maneb. Redox Biol. 2014 Apr 18;2:651-5. doi: 10.1016/j.redox.2014.04.007. eCollection 2014. PubMed PMID: 24936438; PubMed Central PMCID: PMC4052523.

5: Dixit A, Srivastava G, Verma D, Mishra M, Singh PK, Prakash O, Singh MP. Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease. Biochim Biophys Acta. 2013 Aug;1832(8):1227-40. doi: 10.1016/j.bbadis.2013.03.019. Epub 2013 Apr 4. PubMed PMID: 23562983.

6: Bastías-Candia S, Di Benedetto M, D'Addario C, Candeletti S, Romualdi P. Combined exposure to agriculture pesticides, paraquat and maneb, induces alterations in the N/OFQ-NOPr and PDYN/KOPr systems in rats: Relevance to sporadic Parkinson's disease. Environ Toxicol. 2015 May-Jun;30(6):656-63. doi: 10.1002/tox.21943. Epub 2013 Dec 23. PubMed PMID: 24376148.

7: Ben Amara I, Ben Saad H, Hamdaoui L, Karray A, Boudawara T, Ben Ali Y, Zeghal N. Maneb disturbs expression of superoxide dismutase and glutathione peroxidase, increases reactive oxygen species production, and induces genotoxicity in liver of adult mice. Environ Sci Pollut Res Int. 2015 Aug;22(16):12309-22. doi: 10.1007/s11356-015-4434-6. Epub 2015 Apr 23. PubMed PMID: 26210702.

8: Cheng SY, Oh S, Velasco M, Ta C, Montalvo J, Calderone A. RTP801 regulates maneb- and mancozeb-induced cytotoxicity via NF-κB. J Biochem Mol Toxicol. 2014 Jul;28(7):302-11. doi: 10.1002/jbt.21566. Epub 2014 Apr 25. PubMed PMID: 24764117.

9: Hoffman L, Trombetta L, Hardej D. Ethylene bisdithiocarbamate pesticides Maneb and Mancozeb cause metal overload in human colon cells. Environ Toxicol Pharmacol. 2016 Jan;41:78-88. doi: 10.1016/j.etap.2015.11.002. Epub 2015 Nov 7. PubMed PMID: 26650801.

10: Sula B, Ekinci C, Uçak H, Uçmak D, Akkurt ZM, Yavuz D, Arica M, Deveci E. Immunohistochemical and histopathological changes in the skin of rats after maneb application. Anal Quant Cytopathol Histpathol. 2014 Dec;36(6):324-9. PubMed PMID: 25803990.

11: Grosicka-Maciąg E, Szumiło M, Czeczot H, Kurpios-Piec D, Skrzycki M, Rahden-Staroń I. Modulation of antioxidant defense system by the dithiocarbamate fungicides Maneb and Zineb in Chinese hamster V79 cells and the role of N-acetyl-L-cysteine. Food Chem Toxicol. 2013 Oct;60:130-4. doi: 10.1016/j.fct.2013.07.034. Epub 2013 Jul 18. PubMed PMID: 23871785.

12: Shukla S, Singh D, Kumar V, Chauhan AK, Singh S, Ahmad I, Pandey HP, Singh C. NADPH oxidase mediated maneb- and paraquat-induced oxidative stress in rat polymorphs: Crosstalk with mitochondrial dysfunction. Pestic Biochem Physiol. 2015 Sep;123:74-86. doi: 10.1016/j.pestbp.2015.03.007. Epub 2015 Mar 21. PubMed PMID: 26267055.

13: Choi WS, Xia Z. Maneb-induced dopaminergic neuronal death is not affected by loss of mitochondrial complex I activity: results from primary mesencephalic dopaminergic neurons cultured from individual Ndufs4+/+ and Ndufs4-/- mouse embryos. Neuroreport. 2014 Dec 3;25(17):1350-5. doi: 10.1097/WNR.0000000000000271. PubMed PMID: 25275677; PubMed Central PMCID: PMC4213303.

14: Tinakoua A, Bouabid S, Faggiani E, De Deurwaerdère P, Lakhdar-Ghazal N, Benazzouz A. The impact of combined administration of paraquat and maneb on motor and non-motor functions in the rat. Neuroscience. 2015 Dec 17;311:118-29. doi: 10.1016/j.neuroscience.2015.10.021. Epub 2015 Oct 20. PubMed PMID: 26477982.

15: Kurzatkowski DM, Trombetta LD. Maneb causes pro-oxidant effects in the hippocampus of Nrf2 knockout mice. Environ Toxicol Pharmacol. 2013 Sep;36(2):427-36. doi: 10.1016/j.etap.2013.04.016. Epub 2013 May 18. PubMed PMID: 23764462.

16: Li B, He X, Sun Y, Li B. Developmental exposure to paraquat and maneb can impair cognition, learning and memory in Sprague-Dawley rats. Mol Biosyst. 2016 Oct 20;12(10):3088-97. doi: 10.1039/c6mb00284f. Epub 2016 Jul 27. PubMed PMID: 27460631.

17: Caputi FF, Carretta D, Lattanzio F, Palmisano M, Candeletti S, Romualdi P. Proteasome subunit and opioid receptor gene expression down-regulation induced by paraquat and maneb in human neuroblastoma SH-SY5Y cells. Environ Toxicol Pharmacol. 2015 Nov;40(3):895-900. doi: 10.1016/j.etap.2015.09.019. Epub 2015 Oct 3. PubMed PMID: 26498265.

18: Allen JL, Liu X, Weston D, Conrad K, Oberdörster G, Cory-Slechta DA. Consequences of developmental exposure to concentrated ambient ultrafine particle air pollution combined with the adult paraquat and maneb model of the Parkinson's disease phenotype in male mice. Neurotoxicology. 2014 Mar;41:80-8. doi: 10.1016/j.neuro.2014.01.004. Epub 2014 Jan 30. PubMed PMID: 24486957; PubMed Central PMCID: PMC3978140.

19: Wills J, Credle J, Oaks AW, Duka V, Lee JH, Jones J, Sidhu A. Paraquat, but not maneb, induces synucleinopathy and tauopathy in striata of mice through inhibition of proteasomal and autophagic pathways. PLoS One. 2012;7(1):e30745. doi: 10.1371/journal.pone.0030745. Epub 2012 Jan 23. PubMed PMID: 22292029; PubMed Central PMCID: PMC3264632.

20: Parodi DA, Sjarif J, Chen Y, Allard P. Reproductive toxicity and meiotic dysfunction following exposure to the pesticides Maneb, Diazinon and Fenarimol. Toxicol Res (Camb). 2015 May;4(3):645-654. PubMed PMID: 25984295; PubMed Central PMCID: PMC4433152.