Navafenterol

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MedKoo CAT#: 598424

CAS#: 1435519-06-4

Description: Navafenterol, also known as AZD-8871, is a new chemical entity possessing long-acting effect in a single molecule which presents a novel treatment approach to chronic obstructive pulmonary disease [COPD] and potentially also asthma (in combination with an inhaled corticosteroid [ICS]).


Price and Availability

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Pricing updated 2020-08-09. Prices are subject to change without notice.

Navafenterol is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 598424
Name: Navafenterol
CAS#: 1435519-06-4
Chemical Formula: C38H42N6O6S2
Exact Mass: 742.2607
Molecular Weight: 742.91
Elemental Analysis: C, 61.44; H, 5.70; N, 11.31; O, 12.92; S, 8.63


Synonym: AZD-8871; AZD 8871; AZD8871; LAS-191351; LAS 191351; LAS191351; Navafenterol

IUPAC/Chemical Name: (1r,4r)-4-((3-(5-((((R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-1H-benzo[d][1,2,3]triazol-1-yl)propyl)(methyl)amino)cyclohexyl 2-hydroxy-2,2-di(thiophen-2-yl)acetate

InChi Key: ZNKWRAKPQQZLNX-ZDQHWEPJSA-N

InChi Code: InChI=1S/C38H42N6O6S2/c1-43(25-8-10-26(11-9-25)50-37(48)38(49,33-5-2-19-51-33)34-6-3-20-52-34)17-4-18-44-30-14-7-24(21-29(30)41-42-44)22-39-23-32(46)27-12-15-31(45)36-28(27)13-16-35(47)40-36/h2-3,5-7,12-16,19-21,25-26,32,39,45-46,49H,4,8-11,17-18,22-23H2,1H3,(H,40,47)/t25-,26-,32-/m0/s1

SMILES Code: O=C(O[C@H]1CC[C@H](N(CCCN2N=NC3=CC(CNC[C@@H](C4=CC=C(O)C5=C4C=CC(N5)=O)O)=CC=C32)C)CC1)C(C6=CC=CS6)(O)C7=CC=CS7


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Aparici M, Carcasona C, Ramos I, Montero JL, Otal R, Ortiz JL, Cortijo J, Puig C, Vilella D, De Alba J, Doe C, Gavaldà A, Miralpeix M. Pharmacological Profile of AZD8871 (LAS191351), a Novel Inhaled Dual M(3) Receptor Antagonist/β (2)-Adrenoceptor Agonist Molecule with Long-Lasting Effects and Favorable Safety Profile. J Pharmacol Exp Ther. 2019 Jul;370(1):127-136. doi: 10.1124/jpet.118.255620. Epub 2019 May 13. PubMed PMID: 31085697.

2: Singh D, Fuhr R, Jimenez L, Wählby Hamrén U, Jauhiainen A, Malice MP, Balaguer V, Lei A, Aggarwal A, Astbury C, Psallidas I. A Randomized Trial of Dual-Acting Bronchodilator AZD8871 for Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2019 May 15;199(10):1282-1284. doi: 10.1164/rccm.201812-2345LE. PubMed PMID: 30768909.