WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 559171

CAS#: 69448-97-1

Description: Lapidosin is a bioactive chemical.

Chemical Structure

CAS# 69448-97-1

Theoretical Analysis

MedKoo Cat#: 559171
Name: Lapidosin
CAS#: 69448-97-1
Chemical Formula: C16H14O8
Exact Mass: 334.0689
Molecular Weight: 334.28
Elemental Analysis: C, 57.49; H, 4.22; O, 38.29

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Lapidosin;

IUPAC/Chemical Name: methyl (Z)-8-hydroxy-3-(1-hydroxy-3-oxobut-1-en-1-yl)-7-methoxy-4-oxo-4H-chromene-5-carboxylate


InChi Code: InChI=1S/C16H14O8/c1-7(17)4-10(18)9-6-24-15-12(13(9)19)8(16(21)23-3)5-11(22-2)14(15)20/h4-6,18,20H,1-3H3/b10-4-

SMILES Code: O=C(C1=C2C(C(/C(O)=C/C(C)=O)=COC2=C(O)C(OC)=C1)=O)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 334.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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1: Imhasly S, Naegeli H, Baumann S, von Bergen M, Luch A, Jungnickel H, Potratz S, Gerspach C. Metabolomic biomarkers correlating with hepatic lipidosis in dairy cows. BMC Vet Res. 2014 Jun 2;10:122. doi: 10.1186/1746-6148-10-122. PubMed PMID: 24888604; PubMed Central PMCID: PMC4048253.

2: Sato H, Takahashi N, Sato E, Kisu K, Ito S, Saito T. Pathology of glomerular lipidosis. Clin Exp Nephrol. 2014 Apr;18(2):194-6. doi: 10.1007/s10157-013-0882-9. Epub 2013 Oct 16. Review. PubMed PMID: 24129560.

3: Snyder JM, Treuting PM, Brabb T, Miller KE, Covey E, Lencioni KL. Hepatic Lipidosis in a Research Colony of Big Brown Bats (Eptesicus fuscus). Comp Med. 2015 Apr;65(2):133-9. PubMed PMID: 25926399; PubMed Central PMCID: PMC4408899.

4: Stejskal V, Kouřil J, Policar T, Svobodová Z. Splenic lipidosis in intensively cultured perch, Perca fluviatilis L. J Fish Dis. 2016 Jan;39(1):87-93. doi: 10.1111/jfd.12327. Epub 2015 Jan 14. PubMed PMID: 25589287.

5: Wang C, Li Q, Zhen J, Xu Y, Sun S. Simvastatin ameliorates renal lipidosis through the suppression of renal CXCL16 expression in mice with adriamycin-induced nephropathy. Int J Clin Exp Pathol. 2015 Dec 1;8(12):15696-707. eCollection 2015. PubMed PMID: 26884839; PubMed Central PMCID: PMC4730052.

6: Feriozzi S. [Glomerular lipidosis]. G Ital Nefrol. 2016 Malattie Metaboliche e Rene;33(S68). pii: gin/33.S68.11. Italian. PubMed PMID: 27960019.

7: Ouyang Q, Huang Z, Lin H, Ni J, Lu H, Chen X, Wang Z, Lin L. Apolipoprotein E deficiency and high-fat diet cooperate to trigger lipidosis and inflammation in the lung via the toll-like receptor 4 pathway. Mol Med Rep. 2015 Aug;12(2):2589-97. doi: 10.3892/mmr.2015.3774. Epub 2015 May 12. PubMed PMID: 25975841; PubMed Central PMCID: PMC4464450.

8: Pillitteri CA, Craig LE. Hepatic encephalopathy associated with hepatic lipidosis in llamas (Lama glama). Vet Pathol. 2013 Jan;50(1):177-81. doi: 10.1177/0300985812442692. Epub 2012 Apr 4. PubMed PMID: 22492209.

9: Porubsky S, Kuppe C, Maier T, Birk HW, Wörnle M, Moeller MJ, Floege J, Gröne HJ. Renal lipidosis in patients enrolled in a methadone substitution program. Arch Pathol Lab Med. 2014 May;138(5):689-93. doi: 10.5858/arpa.2013-0075-CR. PubMed PMID: 24786128.

10: Brenner K, KuKanich KS, Smee NM. Refeeding syndrome in a cat with hepatic lipidosis. J Feline Med Surg. 2011 Aug;13(8):614-7. doi: 10.1016/j.jfms.2011.05.001. Epub 2011 Jun 29. PubMed PMID: 21719333.

11: Mazaki-Tovi M, Abood SK, Segev G, Schenck PA. Alterations in adipokines in feline hepatic lipidosis. J Vet Intern Med. 2013 Mar-Apr;27(2):242-9. doi: 10.1111/jvim.12055. Epub 2013 Mar 10. PubMed PMID: 23480841.

12: Armstrong PJ, Blanchard G. Hepatic lipidosis in cats. Vet Clin North Am Small Anim Pract. 2009 May;39(3):599-616. doi: 10.1016/j.cvsm.2009.03.003. Review. PubMed PMID: 19524794.

13: Anholt H, Himsworth C, Britton A. Polioencephalomalacia and Heart Failure Secondary to Presumptive Thiamine Deficiency, Hepatic Lipidosis, and Starvation in 2 Abandoned Siamese Cats. Vet Pathol. 2016 Jul;53(4):840-3. doi: 10.1177/0300985815620836. Epub 2016 Jan 20. PubMed PMID: 26792845.

14: Murai A, Murakami M, Sakai H, Shimizu H, Murata K, Yanai T. Glomerular lipidosis accompanied by renal tubular oxalosis in wild and laboratory-reared Japanese rock ptarmigans (Lagopus mutus japonicus). Avian Dis. 2011 Dec;55(4):709-13. PubMed PMID: 22312998.

15: Boyle MC, Crabbs TA, Wyde ME, Painter JT, Hill GD, Malarkey DE, Lieuallen WG, Nyska A. Intestinal lymphangiectasis and lipidosis in rats following subchronic exposure to indole-3-carbinol via oral gavage. Toxicol Pathol. 2012 Jun;40(4):561-76. doi: 10.1177/0192623311436178. Epub 2012 Feb 9. PubMed PMID: 22328411.

16: Porter TD, Banerjee S, Stolarczyk EI, Zou L. Suppression of cytochrome P450 reductase (POR) expression in hepatoma cells replicates the hepatic lipidosis observed in hepatic POR-null mice. Drug Metab Dispos. 2011 Jun;39(6):966-73. doi: 10.1124/dmd.111.038562. Epub 2011 Mar 2. PubMed PMID: 21368239; PubMed Central PMCID: PMC3100902.

17: Trott KA, Giannitti F, Rimoldi G, Hill A, Woods L, Barr B, Anderson M, Mete A. Fatty liver hemorrhagic syndrome in the backyard chicken: a retrospective histopathologic case series. Vet Pathol. 2014 Jul;51(4):787-95. doi: 10.1177/0300985813503569. Epub 2013 Oct 3. PubMed PMID: 24091813.

18: Gerloff BJ, Herdt TH, Emery RS. Relationship of hepatic lipidosis to health and performance in dairy cattle. J Am Vet Med Assoc. 1986 Apr 15;188(8):845-50. PubMed PMID: 3519553.

19: Bocchini N, Giantin M, Crivellente F, Ferraresso S, Faustinelli I, Dacasto M, Cristofori P. Molecular biomarkers of phospholipidosis in rat blood and heart after amiodarone treatment. J Appl Toxicol. 2015 Jan;35(1):90-103. PubMed PMID: 25580480.

20: Bornemann A, Harzer K. [Lysosomal storage diseases: A brief summary]. Pathologe. 2015 Sep;36(5):485-93. doi: 10.1007/s00292-015-0053-8. Review. German. PubMed PMID: 26314267.