RE 1492

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 461189

CAS#: 112169-14-9

Description: RE 1492 is an oligoamine that when combined with antithrombic drugs give it an antiplatelet effect.

Chemical Structure

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RE 1492
CAS# 112169-14-9
Instruction

Theoretical Analysis

MedKoo Cat#: 461189
Name: RE 1492
CAS#: 112169-14-9
Chemical Formula: C39H51N3
Exact Mass: 561.41
Molecular Weight: 561.850
Elemental Analysis: C, 83.37; H, 9.15; N, 7.48

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: RE 1492; RE-1492; RE1492;

IUPAC/Chemical Name: N,N',N''-(benzene-1,3,5-triyltris(methylene))tris(4-phenylbutan-1-amine)

InChi Key: RPSXXPUMOFOJAV-UHFFFAOYSA-N

InChi Code: InChI=1S/C39H51N3/c1-4-16-34(17-5-1)22-10-13-25-40-31-37-28-38(32-41-26-14-11-23-35-18-6-2-7-19-35)30-39(29-37)33-42-27-15-12-24-36-20-8-3-9-21-36/h1-9,16-21,28-30,40-42H,10-15,22-27,31-33H2

SMILES Code: c1(CNCCCCc2ccccc2)cc(CNCCCCc3ccccc3)cc(CNCCCCc4ccccc4)c1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 561.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Rehse K, Ciborski T. Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XXVI: Antiplatelet and antithrombotic effects of the oligoamine RE 1492 in combination with standard and future antithrombotic drugs. Arch Pharm (Weinheim). 1995 Apr;328(4):333-7. PubMed PMID: 7611829.

2: Kesselhut A, Ebel H, von Bruchhausen F, Rehse K. Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XXV: Interactions of the oligoamine RE 1492 with biomembranes. Arch Pharm (Weinheim). 1995 Jan;328(1):21-7. PubMed PMID: 7695469.

3: Rehse K, Müller S. Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XXIX: Influence of the antithrombotic oligoamine RE 1492 on the storage of red blood cells, morphology, their potassium and ATP content, hemolysis and viability. Arch Pharm (Weinheim). 1995 Apr;328(4):339-42. PubMed PMID: 7611830.

4: Neumann M, Müller S, Grosse J, Lerche D, Rehse K. Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XXIII: Influence of the oligoamine RE 1492 on the deformability of red blood cells. Arch Pharm (Weinheim). 1994 Aug;327(8):497-501. PubMed PMID: 7944905.

5: Rehse K, Kaehler H, Kuberka H. [Aggregation inhibiting and anticoagulant effects of oligoamines. 13. Improvement in the storage of whole blood and erythrocyte suspensions with oligoamines]. Arch Pharm (Weinheim). 1990 Aug;323(8):475-9. German. PubMed PMID: 2278513.

6: Rehse K, Ciborski T, Müller B. Platelet aggregation inhibiting and anticoagulant effects of oligoamines, XXVII. Inhibition of leucocyte adherence to endothelium by the oligoamine RE 1492C and the NO-donor RE 2047. Arch Pharm (Weinheim). 1995 Feb;328(2):125-6. PubMed PMID: 7726736.