Alclometasone
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592496

CAS#: 67452-97-5

Description: Alclometasone is a topical corticosteroid for treatment of atopic dermatitis and other dermatoses.


Chemical Structure

img
Alclometasone
CAS# 67452-97-5

Theoretical Analysis

MedKoo Cat#: 592496
Name: Alclometasone
CAS#: 67452-97-5
Chemical Formula: C22H29ClO5
Exact Mass: 408.17
Molecular Weight: 408.920
Elemental Analysis: C, 64.62; H, 7.15; Cl, 8.67; O, 19.56

Price and Availability

Size Price Availability Quantity
2.5mg USD 405
25mg USD 2250
Bulk inquiry

Synonym: Alclometasone; Alclometasone

IUPAC/Chemical Name: 7alpha-Chloro-16alpha-methylprednisolone

InChi Key: FJXOGVLKCZQRDN-NJCFBWGQSA-N

InChi Code: InChI=1S/C22H29ClO5/c1-11-6-14-18-15(23)8-12-7-13(25)4-5-20(12,2)19(18)16(26)9-21(14,3)22(11,28)17(27)10-24/h4-5,7,11,14-16,18-19,24,26,28H,6,8-10H2,1-3H3/t11-,14+,15-,16?,18-,19+,20+,21+,22+/m1/s1

SMILES Code: O=C1C=C[C@]2(C)[C@@]3([H])C(O)C[C@]4(C)[C@](C(CO)=O)(O)[C@H](C)C[C@@]4([H])[C@]3([H])[C@H](Cl)CC2=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 408.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from http://www.ncbi.nlm.nih.gov/books/NBK501285/ PubMed PMID: 30000344.

2: Sun Y, Narayan VA, Wittenberg GM. Side effect profile similarities shared between antidepressants and immune-modulators reveal potential novel targets for treating major depressive disorders. BMC Pharmacol Toxicol. 2016 Oct 21;17(1):47. PubMed PMID: 27765060; PubMed Central PMCID: PMC5073882.

3: Lacouture ME, Keefe DM, Sonis S, Jatoi A, Gernhardt D, Wang T, Doherty JP, Giri N, Nadanaciva S, O'Connell J, Sbar E, Piperdi B, Garon EB. A phase II study (ARCHER 1042) to evaluate prophylactic treatment of dacomitinib-induced dermatologic and gastrointestinal adverse events in advanced non-small-cell lung cancer. Ann Oncol. 2016 Sep;27(9):1712-8. doi: 10.1093/annonc/mdw227. Epub 2016 Jun 10. PubMed PMID: 27287210.

4: Ulff E, Maroti M, Serup J, Falkmer U. A potent steroid cream is superior to emollients in reducing acute radiation dermatitis in breast cancer patients treated with adjuvant radiotherapy. A randomised study of betamethasone versus two moisturizing creams. Radiother Oncol. 2013 Aug;108(2):287-92. doi: 10.1016/j.radonc.2013.05.033. Epub 2013 Jul 2. PubMed PMID: 23827771.

5: Zimmerman B, Chamlin SL. A 12-year-old boy with foot lesions. Pediatr Ann. 2013 Jan;42(1):11-2. doi: 10.3928/00904481-20121221-12. PubMed PMID: 23316825.

6: Yamamoto Y, Fukami T, Koide T, Suzuki T, Hiyama Y, Tomono K. Pharmaceutical evaluation of steroidal ointments by ATR-IR chemical imaging: distribution of active and inactive pharmaceutical ingredients. Int J Pharm. 2012 Apr 15;426(1-2):54-60. doi: 10.1016/j.ijpharm.2012.01.017. Epub 2012 Jan 20. PubMed PMID: 22286017.

7: Paller AS, Eichenfield LF, Kirsner RS, Shull T, Jaracz E, Simpson EL; US Tacrolimus Ointment Study Group. Three times weekly tacrolimus ointment reduces relapse in stabilized atopic dermatitis: a new paradigm for use. Pediatrics. 2008 Dec;122(6):e1210-8. doi: 10.1542/peds.2008-1343. Epub 2008 Nov 17. PubMed PMID: 19015204.

8: Isaksson M. Corticosteroid contact allergy--the importance of late readings and testing with corticosteroids used by the patients. Contact Dermatitis. 2007 Jan;56(1):56-7. PubMed PMID: 17177720.

9: Nakagawa H. Comparison of the efficacy and safety of 0.1% tacrolimus ointment with topical corticosteroids in adult patients with atopic dermatitis: review of randomised, double-blind clinical studies conducted in Japan. Clin Drug Investig. 2006;26(5):235-46. Review. PubMed PMID: 17163257.

10: Boyd AS. Localized chronic cutaneous lupus erythematosus masquerading as pigmented lesions: a new clinical subset? Lupus. 2006;15(5):292-5. PubMed PMID: 16761504.

11: Ujiie H, Shimizu T, Shimizu H. Cutaneous reactions to imatinib mesylate treated by topical steroid. Am J Hematol. 2005 Mar;78(3):246. PubMed PMID: 15726597.

12: Ciconte A, Mills AE, Shipley A, Marks R. Subacute cutaneous lupus erythematosus presenting in a child. Australas J Dermatol. 2002 Feb;43(1):62-4. PubMed PMID: 11869212.

13: Brazzini B, Pimpinelli N. New and established topical corticosteroids in dermatology: clinical pharmacology and therapeutic use. Am J Clin Dermatol. 2002;3(1):47-58. Review. PubMed PMID: 11817968.

14: Sakuma S, Higashi Y, Sato N, Sasakawa T, Sengoku T, Ohkubo Y, Amaya T, Goto T. Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids). Int Immunopharmacol. 2001 Jun;1(6):1219-26. PubMed PMID: 11407316.

15: Iwakiri K, Hata M, Miura Y, Numano K, Yuge M, Sasaki E. Allergic contact dermatitis due to bendazac and alclometasone dipropionate. Contact Dermatitis. 1999 Oct;41(4):218-39. Review. PubMed PMID: 10515101.

16: Sengoku T, Morita K, Sakuma S, Motoyama Y, Goto T. Possible inhibitory mechanism of FK506 (tacrolimus hydrate) ointment for atopic dermatitis based on animal models. Eur J Pharmacol. 1999 Aug 27;379(2-3):183-9. PubMed PMID: 10497905.

17: Stitt WZ, Scott GA, Martin RE, Gaspari AA. Multiple chemical sensitivities, including iatrogenic allergic contact dermatitis, in a patient with chronic actinic dermatitis: implications for management. Am J Contact Dermat. 1996 Sep;7(3):166-70. PubMed PMID: 8957333.

18: Eubanks LE, McBurney EI, Galen W, Reed R. Linear scleroderma in children. Int J Dermatol. 1996 May;35(5):330-6. Review. PubMed PMID: 8734654.

19: Lepoittevin JP, Drieghe J, Dooms-Goossens A. Studies in patients with corticosteroid contact allergy. Understanding cross-reactivity among different steroids. Arch Dermatol. 1995 Jan;131(1):31-7. PubMed PMID: 7826093.

20: Nilsson EJ, Henning CG, Magnusson J. Topical corticosteroids and Staphylococcus aureus in atopic dermatitis. J Am Acad Dermatol. 1992 Jul;27(1):29-34. PubMed PMID: 1619073.