Calcifediol monohydrate
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MedKoo CAT#: 461179

CAS#: 63283-36-3 (hydrate)

Description: Calcifediol is a prehormone that is produced in the liver. Physicians worldwide measure this metabolite to determine a patient's vitamin D status. The blood concentration of calcifediol is considered the best indicator of vitamin D status.


Chemical Structure

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Calcifediol monohydrate
CAS# 63283-36-3 (hydrate)

Theoretical Analysis

MedKoo Cat#: 461179
Name: Calcifediol monohydrate
CAS#: 63283-36-3 (hydrate)
Chemical Formula: C27H46O3
Exact Mass: 418.3447
Molecular Weight: 418.66
Elemental Analysis: C, 77.46; H, 11.08; O, 11.46

Price and Availability

Size Price Availability Quantity
10.0mg USD 450.0 2 Weeks
50.0mg USD 1850.0 2 Weeks
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Related CAS #: 63283-36-3 (hydrate)   19356-17-3 (anhydrous)    

Synonym: Calcifediol monohydrate; Calderol; Dedrogyl; Rayaldee; U 32070E; U-32070E; U32070E; 2,5-Hydroxyvitamin D3 monohydrate

IUPAC/Chemical Name: (S,Z)-3-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexan-1-ol hydrate

InChi Key: WRLFSJXJGJBFJQ-WPUCQFJDSA-N

InChi Code: InChI=1S/C27H44O2.H2O/c1-19-10-13-23(28)18-22(19)12-11-21-9-7-17-27(5)24(14-15-25(21)27)20(2)8-6-16-26(3,4)29;/h11-12,20,23-25,28-29H,1,6-10,13-18H2,2-5H3;1H2/b21-11+,22-12-;/t20-,23+,24-,25+,27-;/m1./s1

SMILES Code: C=C(CC1)/C(C[C@H]1O)=C\C=C2[C@@]3([H])[C@@](CCC\2)(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC3.[H]O[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 418.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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16: Dauletbaev N, Herscovitch K, Das M, Chen H, Bernier J, Matouk E, Bérubé J, Rousseau S, Lands LC. Down-regulation of IL-8 by high-dose vitamin D is specific to hyperinflammatory macrophages and involves mechanisms beyond up-regulation of DUSP1. Br J Pharmacol. 2015 Oct;172(19):4757-71. doi: 10.1111/bph.13249. PubMed PMID: 26178144; PubMed Central PMCID: PMC4594277.

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