Rauvanine

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MedKoo CAT#: 461174

CAS#: 3148-42-3

Description: Rauvanine an alkaloid of Rauwolfia vomitora.


Chemical Structure

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Rauvanine
CAS# 3148-42-3

Theoretical Analysis

MedKoo Cat#: 461174
Name: Rauvanine
CAS#: 3148-42-3
Chemical Formula: C23H28N2O5
Exact Mass: 412.20
Molecular Weight: 412.480
Elemental Analysis: C, 66.97; H, 6.84; N, 6.79; O, 19.39

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Rauvanine; Rauvanin;

IUPAC/Chemical Name: methyl (4aR,13bS,14aS)-10,11-dimethoxy-4-methyl-4a,5,7,8,13,13b,14,14a-octahydro-4H-indolo[2,3-a]pyrano[3,4-g]quinolizine-1-carboxylate

InChi Key: FGWJRZQNNZVCHR-NJJPXGRNSA-N

InChi Code: InChI=1S/C23H28N2O5/c1-12-16-10-25-6-5-13-15-8-20(27-2)21(28-3)9-18(15)24-22(13)19(25)7-14(16)17(11-30-12)23(26)29-4/h8-9,11-12,14,16,19,24H,5-7,10H2,1-4H3/t12?,14-,16+,19-/m0/s1

SMILES Code: [H][C@]12C(NC3=C4C=C(OC)C(OC)=C3)=C4CCN1C[C@@]5(C(C)OC=C(C(OC)=O)[C@]5(C2)[H])[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 412.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Quevauviller A, Sarrazin G, Takenaka Y. [Action of rauvanine on the cardiovascular system, an alkaloid of Rauwolfia vomitoria Afz]. Ann Pharm Fr. 1972 Feb;30(2):81-4. French. PubMed PMID: 5051264.

2: GOUTAREL R, GUT M, PARELLO J. [A new alkaloid, isolated from Rauwolfia vomitoria Afz., rauvanine, isomer of reserpiline]. C R Hebd Seances Acad Sci. 1961 Nov 27;253:2589-91. French. PubMed PMID: 13900856.

3: QUEVAUVILLER A, BLANPIN O, TAKENAKA Y. [On the pharmacodynamics of rauvanine, a new alkaloid extracted from Rauwolfia vomitoria Afz. (Apocynacea)]. Ann Pharm Fr. 1963 May;21:399-404. French. PubMed PMID: 13972741.

4: Quevauviller A, Sarrazin G, Takenaka Y. [Actions of rauvanine, an alkaloid of Rauwolfia vomitora Afz. on the central nervous system in mice]. Ann Pharm Fr. 1972 Jan;30(1):45-9. French. PubMed PMID: 5043667.