Alcian blue

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592486

CAS#: 12040-44-7

Description: Alcian blue is a copper-containing dye used as a gelling agent for lubricants, for staining of bacteria and for the dyeing of histiocytes and fibroblasts in vivo.


Chemical Structure

img
Alcian blue
CAS# 12040-44-7

Theoretical Analysis

MedKoo Cat#: 592486
Name: Alcian blue
CAS#: 12040-44-7
Chemical Formula: C56H70Cl4CuN16S4
Exact Mass: 1,297.29
Molecular Weight: 1,300.874
Elemental Analysis: C, 51.70; H, 5.42; Cl, 10.90; Cu, 4.88; N, 17.23; S, 9.86

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Alcian blue

IUPAC/Chemical Name: (6Z,12E,13Z,19Z,21E,26Z)-2,9,16,24-tetrakis((((dimethylamino)(dimethyliminio)methyl)thio)methyl)-5H,28H-phthalocyanine-29,31-diide copper(II) chloride

InChi Key: OBSNQDWGQFWBKH-UHFFFAOYSA-J

InChi Code: InChI=1S/C56H70N16S4.4ClH.Cu/c1-65(2)53(66(3)4)73-29-33-17-21-37-41(25-33)49-58-45(37)57-46-38-22-18-35(31-75-55(69(9)10)70(11)12)27-43(38)51(59-46)64-52-44-28-36(32-76-56(71(13)14)72(15)16)20-24-40(44)48(63-52)62-50-42-26-34(19-23-39(42)47(60-49)61-50)30-74-54(67(5)6)68(7)8;;;;;/h17-28,48,52H,29-32H2,1-16H3;4*1H;/q+2;;;;;+2/p-4

SMILES Code: c12=NC3=NC(=NC4[N-]C(N=C5N=C(N=c([n-]1)c1c2cc(CS/C(=[N+](/C)C)N(C)C)cc1)c1c5cc(CS/C(=[N+](\C)C)N(C)C)cc1)c1c4ccc(c1)CS/C(=[N+](/C)C)N(C)C)c1c3ccc(c1)CS/C(=[N+](/C)C)N(C)C.[Cl-].[Cl-].[Cl-].[Cl-].[Cu+2]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,300.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Li Q, Zhang L, Huang Z, Wang F, Wu Z, Wang Y. [Effects of recombinant human interferon β1a on the chondrogenic differentiation of human bone marrow mesenchymal stem cell]. Sheng Wu Gong Cheng Xue Bao. 2018 Jun 25;34(6):964-972. doi: 10.13345/j.cjb.170443. Chinese. PubMed PMID: 29943542.

2: Caraşca C, Simion G, Nechifor-Boilă AC, Boeriu AM, Dobru ED. A rare case of signet-ring cell carcinoma associated with poorly differentiated adenocarcinoma of the non-ampullary duodenum. Rom J Morphol Embryol. 2018;59(1):311-315. PubMed PMID: 29940643.

3: Gonzaga AK, de Oliveira DH, Lopes ML, Filho TJ, Queiroz LM, da Silveira ÉJ. Clinicopathological study of oral focal mucinosis: a retrospective case series. Med Oral Patol Oral Cir Bucal. 2018 Jul 1;23(4):e401-e405. doi: 10.4317/medoral.22291. PubMed PMID: 29924755.

4: Bakir M, Geyikoglu F, Koc K, Cerig S. Therapeutic effects of oleuropein on cisplatin-induced pancreas injury in rats. J Cancer Res Ther. 2018 Apr-Jun;14(3):671-678. doi: 10.4103/jcrt.JCRT_1040_16. PubMed PMID: 29893338.

5: Hu GM, Feng YK, Liu QY, Chen HP, Fu WJ, Zhang M, Chang J, Gu B, Wu HF, Ren JL. [Gastrointestinal leiomyoma with interstitial cells of Cajal: mimicker of gastrointestinal stromal tumor]. Zhonghua Bing Li Xue Za Zhi. 2018 Jun 8;47(6):438-443. doi: 10.3760/cma.j.issn.0529-5807.2018.06.010. Chinese. PubMed PMID: 29886588.

6: Gao F, Lv TR, Zhou JC, Qin XD. Effects of obesity on the healing of bone fracture in mice. J Orthop Surg Res. 2018 Jun 8;13(1):145. doi: 10.1186/s13018-018-0837-7. PubMed PMID: 29880016; PubMed Central PMCID: PMC5992669.

7: Quach DT, Le HM, Nguyen TS, Hiyama T. The Distribution of Incomplete Gastric Intestinal Metaplasia (GIM) Subtype among Biopsy Sites according to the Updated Sydney System and Its Association with GIM Extension. Gastroenterol Res Pract. 2018 May 8;2018:4938730. doi: 10.1155/2018/4938730. eCollection 2018. PubMed PMID: 29853861; PubMed Central PMCID: PMC5964434.

8: Gao K, Wang S, Wang Q. [Effect of icariin on serum bone turnover markers expressions and histology changes in mouse osteoarthritis model]. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Aug 1;31(8):963-969. doi: 10.7507/1002-1892.201703044. Chinese. PubMed PMID: 29806434.

9: Rehder H, Laccone F, Kircher SG, Schild RL, Rapp C, Bald R, Schulze B, Behunova J, Neesen J, Schoner K. Piepkorn type of osteochondrodysplasia: Defining the severe end of FLNB-related skeletal disorders in three fetuses and a 106-year-old exhibit. Am J Med Genet A. 2018 May 23. doi: 10.1002/ajmg.a.38828. [Epub ahead of print] PubMed PMID: 29797497.

10: Padala SS, Kiresur MA, Ananthaneni A, Guduru VS, Puneeth HK, Bhavana B. Comparsion of staining characteristics of Toto bodies. Biotech Histochem. 2018 May 21:1-4. doi: 10.1080/10520295.2018.1441441. [Epub ahead of print] PubMed PMID: 29781718.

11: Liang ZJ, Lu X, Li DQ, Liang YD, Zhu DD, Wu FX, Yi XL, He N, Huang YQ, Tang C, Li HM. Precise Intradermal Injection of Nanofat-Derived Stromal Cells Combined with Platelet-Rich Fibrin Improves the Efficacy of Facial Skin Rejuvenation. Cell Physiol Biochem. 2018;47(1):316-329. doi: 10.1159/000489809. Epub 2018 May 11. PubMed PMID: 29768259.

12: Jakobiec FA, Zakka FR, Papakostas T, Mukai S. Early Neuroblastic and Astrocytic Differentiation Demonstrated Immunohistochemically in a Small Intraocular Medulloepithelioma. Ocul Oncol Pathol. 2018 Apr;4(3):176-181. doi: 10.1159/000481287. Epub 2017 Nov 8. PubMed PMID: 29765950; PubMed Central PMCID: PMC5939715.

13: Yi D, Xiang W, Zhang Q, Cen Y, Su Q, Zhang F, Lu Y, Zhao H, Fu P. Human Glioblastoma-Derived Mesenchymal Stem Cell to Pericytes Transition and Angiogenic Capacity in Glioblastoma Microenvironment. Cell Physiol Biochem. 2018;46(1):279-290. doi: 10.1159/000488429. Epub 2018 Mar 22. PubMed PMID: 29590646.

14: Brakel KA, VanHoy G, Hinds A, Breitbach J, Premanandan C, Kohnken R. Peritoneal and scrotal carcinomas of unknown origin in two bovine calves. J Vet Diagn Invest. 2018 Jul;30(4):609-613. doi: 10.1177/1040638718765617. Epub 2018 Mar 27. PubMed PMID: 29582708.

15: Stecco C, Fede C, Macchi V, Porzionato A, Petrelli L, Biz C, Stern R, De Caro R. The fasciacytes: A new cell devoted to fascial gliding regulation. Clin Anat. 2018 Jul;31(5):667-676. doi: 10.1002/ca.23072. Epub 2018 Apr 14. PubMed PMID: 29575206.

16: Bottegoni C, Farinelli L, Aquili A, Manzotti S, Baldini M, Gigante A. Fibrocartilaginous metaplasia identified in the long head of the biceps brachii. J Shoulder Elbow Surg. 2018 Jul;27(7):1221-1225. doi: 10.1016/j.jse.2018.02.042. Epub 2018 Mar 19. PubMed PMID: 29567036.

17: Nakamura H, Tomuschat C, Coyle D, O'Donnel AM, Lim T, Puri P. Altered goblet cell function in Hirschsprung's disease. Pediatr Surg Int. 2018 Feb;34(2):121-128. doi: 10.1007/s00383-017-4178-0. Epub 2018 Jan 30. PubMed PMID: 29383490.

18: Zhao RR, Ackers-Johnson M, Stenzig J, Chen C, Ding T, Zhou Y, Wang P, Ng SL, Li PY, Teo G, Rudd PM, Fawcett JW, Foo RSY. Targeting Chondroitin Sulfate Glycosaminoglycans to Treat Cardiac Fibrosis in Pathological Remodeling. Circulation. 2018 Jun 5;137(23):2497-2513. doi: 10.1161/CIRCULATIONAHA.117.030353. Epub 2018 Jan 25. PubMed PMID: 29371215.

19: Dos Santos JL, de Almeida Milani Altemani AM, Trivellato AE, Sverzut CE, Almeida LY, Teixeira LR, Ribeiro-Silva A, León JE. Intraoral Pigmented Low-Grade Adenocarcinoma, Not Otherwise Specified: Case Report and Immunohistochemical Study. Head Neck Pathol. 2017 Dec 22. doi: 10.1007/s12105-017-0875-1. [Epub ahead of print] PubMed PMID: 29274041.

20: Shergill KK, Shergill GS, Pillai HJ. Gelatinous transformation of bone marrow: rare or underdiagnosed? Autops Case Rep. 2017 Dec 8;7(4):8-17. doi: 10.4322/acr.2017.039. eCollection 2017 Oct-Dec. Review. PubMed PMID: 29259927; PubMed Central PMCID: PMC5724049.