Abieslactone

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 598345

CAS#: 33869-93-1

Description: Abieslacton has anti-tumor promoting activity; from several Abies genus.


Chemical Structure

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Abieslactone
CAS# 33869-93-1

Theoretical Analysis

MedKoo Cat#: 598345
Name: Abieslactone
CAS#: 33869-93-1
Chemical Formula: C31H48O4
Exact Mass: 484.36
Molecular Weight: 484.720
Elemental Analysis: C, 76.82; H, 9.98; O, 13.20

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Abieslactone;

IUPAC/Chemical Name: Lanosta-7,24-dien-26-oic acid, 23-hydroxy-3-methoxy-, gamma-lactone, (3alpha,9beta,23R)-

InChi Key: AYHUWYQKFAIBIY-YCSGLTLBSA-N

InChi Code: InChI=1S/C31H48O4/c1-19-16-21(32)17-20(2)27(33)35-18-29(4)25-9-8-24-23(28(25,3)13-12-26(29)34-7)11-15-30(5)22(19)10-14-31(24,30)6/h8,17,19,21-23,25-26,32H,9-16,18H2,1-7H3/b20-17-/t19-,21-,22-,23+,25-,26-,28-,29-,30-,31+/m1/s1

SMILES Code: C[C@]1(COC2=O)[C@H](OC)CC[C@]3(C)[C@@]4([H])CC[C@]5(C)[C@@H]([C@H](C)C[C@@H](O)/C=C2/C)CC[C@](C)5C4=CC[C@@]13[H]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 484.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wang GW, Lv C, Shi ZR, Zeng RT, Dong XY, Zhang WD, Liu RH, Shan L, Shen YH. Abieslactone induces cell cycle arrest and apoptosis in human hepatocellular carcinomas through the mitochondrial pathway and the generation of reactive oxygen species. PLoS One. 2014 Dec 11;9(12):e115151. doi: 10.1371/journal.pone.0115151. eCollection 2014. PubMed PMID: 25502685; PubMed Central PMCID: PMC4263740.

2: Takayasu J, Tanaka R, Matsunaga S, Ueyama H, Tokuda H, Hasegawa T, Nishino A, Nishino H, Iwashima A. Anti-tumor-promoting activity of derivatives of abieslactone, a natural triterpenoid isolated from several Abies genus. Cancer Lett. 1990 Sep;53(2-3):141-4. PubMed PMID: 2208073.

3: UYEO S, OKADA J, MATSUNAGO S. [SELENIUM DEHYDROGENATION OF ABIESLACTONE]. Yakugaku Zasshi. 1964 May;84:453-7. Japanese. PubMed PMID: 14193916.

4: Iwai S, Wei M, Morimura K, Wanibuchi H, Tanaka R, Matsunaga S, Yoshitake A, Seki S, Fukushima S. Possible prevention by abieslactone of development of diethylnitrosamine-initiated GST-P positive foci in the rat liver. Teratog Carcinog Mutagen. 2001;21(3):223-9. PubMed PMID: 11301417.

5: Tanaka R, Matsunaga S. [Terpenoids and steroids from several euphorbiaceae and pinaceae plants]. Yakugaku Zasshi. 1999 May;119(5):319-39. Review. Japanese. PubMed PMID: 10375995.