Neuromedin B

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MedKoo CAT#: 461155

CAS#: 87096-84-2

Description: Neuromedin B (NMB) is a highly conserved bombesin-related peptide found in mammals.


Price and Availability

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Pricing updated 2020-10-31. Prices are subject to change without notice.

Neuromedin B is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 461155
Name: Neuromedin B
CAS#: 87096-84-2
Chemical Formula: C52H73N15O12S
Exact Mass: 1131.5284
Molecular Weight: 1132.3
Elemental Analysis: C, 55.16; H, 6.50; N, 18.56; O, 16.96; S, 2.83


Synonym: Neuromedin B;

IUPAC/Chemical Name: (S)-N1-((5S,8R,11S,17S,20S,23S,26S)-11-((1H-imidazol-5-yl)methyl)-23-((1H-indol-3-yl)methyl)-8-benzyl-5-carbamoyl-17-((R)-1-hydroxyethyl)-20,28-dimethyl-7,10,13,16,19,22,25-heptaoxo-2-thia-6,9,12,15,18,21,24-heptaazanonacosan-26-yl)-2-(2-aminoacetamido)succinamide

InChi Key: YPFNACALNKVZNK-FJGCCFFASA-N

InChi Code: 1S/C52H73N15O12S/c1-27(2)17-36(64-51(78)40(21-41(54)69)61-42(70)22-53)48(75)66-38(19-31-23-57-34-14-10-9-13-33(31)34)47(74)60-28(3)46(73)67-44(29(4)68)52(79)58-25-43(71)62-39(20-32-24-56-26-59-32)50(77)65-37(18-30-11-7-6-8-12-30)49(76)63-35(45(55)72)15-16-80-5/h6-14,23-24,26-29,35-40,44,57,68H,15-22,25,53H2,1-5H3,(H2,54,69)(H2,55,72)(H,56,59)(H,58,79)(H,60,74)(H,61,70)(H,62,71)(H,63,76)(H,64,78)(H,65,77)(H,66,75)(H,67,73)/t28-,29+,35-,36-,37?,38-,39-,40-,44-/m0/s1

SMILES Code: CC(C)C[C@H](NC([C@@H](NC(CN)=O)CC(N)=O)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](Cc1cnc[nH]1)C(N[C@H](Cc2ccccc2)C(N[C@H](C(N)=O)CCSC)=O)=O)=O)=O)[C@@H](C)O)=O)C)=O)Cc3c[nH]c4c3cccc4)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.03.00


References

1: Guo TT, Su J, Ma ZY, Ma JX, Jin MM, Li X, Lei ZH. Cloning of neuromedin B and its receptor in the rabbit and generating a polyclonal antibody to the neuromedin B protein. Gene. 2015 Jun 10;564(1):21-8. doi: 10.1016/j.gene.2015.03.038. Epub 2015 Mar 19. PubMed PMID: 25796599.

2: Mishra SK, Holzman S, Hoon MA. A nociceptive signaling role for neuromedin B. J Neurosci. 2012 Jun 20;32(25):8686-95. doi: 10.1523/JNEUROSCI.1533-12.2012. PubMed PMID: 22723708; PubMed Central PMCID: PMC3395363.

3: Boughton CK, Patel SA, Thompson EL, Patterson M, Curtis AE, Amin A, Chen K, Ghatei MA, Bloom SR, Murphy KG. Neuromedin B stimulates the hypothalamic-pituitary-gonadal axis in male rats. Regul Pept. 2013 Nov 10;187:6-11. doi: 10.1016/j.regpep.2013.10.002. Epub 2013 Oct 10. PubMed PMID: 24120470.

4: Kameda H, Miyoshi H, Shimizu C, Nagai S, Nakamura A, Kondo T, Chida D, Atsumi T. Expression and regulation of neuromedin B in pituitary corticotrophs of male melanocortin 2 receptor-deficient mice. Endocrinology. 2014 Jul;155(7):2492-9. doi: 10.1210/en.2013-2077. Epub 2014 Apr 17. PubMed PMID: 24742195.

5: Saito H, Ikeda R, Inoue K, Nagata S, Kitamura K, Minamino N, Kangawa K, Miyata A. Neuromedin B stimulates proliferation of mouse chondrogenic cell line ATDC5. Peptides. 2012 Aug;36(2):299-302. doi: 10.1016/j.peptides.2012.05.010. Epub 2012 May 28. PubMed PMID: 22652580.

6: Zhang WS, Fei KL, Wu MT, Wu XH, Liang QH. Neuromedin B and its receptor influence the activity of myometrial primary cells in vitro through regulation of Il6 expression via the Rela/p65 pathway in mice. Biol Reprod. 2012 May 17;86(5):154, 1-7. doi: 10.1095/biolreprod.111.095984. Print 2012 May. PubMed PMID: 22262690.

7: Nishimatsu H, Suzuki E, Saito Y, Niimi A, Nomiya A, Yamada D, Homma Y. Neuromedin B Restores Erectile Function by Protecting the Cavernous Body and the Nitrergic Nerves from Injury in a Diabetic Rat Model. PLoS One. 2015 Jul 24;10(7):e0133874. doi: 10.1371/journal.pone.0133874. eCollection 2015. PubMed PMID: 26207818; PubMed Central PMCID: PMC4514746.

8: Saito H, Nakamachi T, Inoue K, Ikeda R, Kitamura K, Minamino N, Shioda S, Miyata A. Autocrine effects of neuromedin B stimulate the proliferation of rat primary osteoblasts. J Endocrinol. 2013 Apr 15;217(2):141-50. doi: 10.1530/JOE-12-0488. Print 2013 May. PubMed PMID: 23428580.

9: Zhang WS, Xie QS, Wu XH, Liang QH. Neuromedin B and its receptor induce labor onset and are associated with the RELA (NFKB P65)/IL6 pathway in pregnant mice. Biol Reprod. 2011 Jan;84(1):113-7. doi: 10.1095/biolreprod.110.085746. Epub 2010 Sep 8. PubMed PMID: 20826731.

10: Ignatjev I, Proniewicz E, Proniewicz LM, Niaura G. Effect of potential on temperature-dependent SERS spectra of neuromedin B on Cu electrode. Phys Chem Chem Phys. 2013 Jan 21;15(3):807-15. doi: 10.1039/c2cp42077e. PubMed PMID: 23202809.

11: Ma Z, Su J, Guo T, Jin M, Li X, Lei Z, Hou Y, Li X, Jia C, Zhang Z, Ahmed E. Neuromedin B and Its Receptor: Gene Cloning, Tissue Distribution and Expression Levels of the Reproductive Axis in Pigs. PLoS One. 2016 Mar 24;11(3):e0151871. doi: 10.1371/journal.pone.0151871. eCollection 2016. PubMed PMID: 27010315; PubMed Central PMCID: PMC4807040.

12: Fleming MS, Ramos D, Han SB, Zhao J, Son YJ, Luo W. The majority of dorsal spinal cord gastrin releasing peptide is synthesized locally whereas neuromedin B is highly expressed in pain- and itch-sensing somatosensory neurons. Mol Pain. 2012 Jul 9;8:52. doi: 10.1186/1744-8069-8-52. PubMed PMID: 22776446; PubMed Central PMCID: PMC3495671.

13: Su PY, Ko MC. The role of central gastrin-releasing peptide and neuromedin B receptors in the modulation of scratching behavior in rats. J Pharmacol Exp Ther. 2011 Jun;337(3):822-9. doi: 10.1124/jpet.111.178970. Epub 2011 Mar 18. PubMed PMID: 21421741; PubMed Central PMCID: PMC3101014.

14: Minamino N, Kangawa K, Matsuo H. Neuromedin B is a major bombesin-like peptide in rat brain: regional distribution of neuromedin B and neuromedin C in rat brain, pituitary and spinal cord. Biochem Biophys Res Commun. 1984 Nov 14;124(3):925-32. PubMed PMID: 6548910.

15: Minamino N, Sudoh T, Kangawa K, Matsuo H. Neuromedin B-32 and B-30: two "big" neuromedin B identified in porcine brain and spinal cord. Biochem Biophys Res Commun. 1985 Jul 31;130(2):685-91. PubMed PMID: 4026853.

16: Jones PM, Withers DJ, Ghatei MA, Bloom SR. Evidence for neuromedin-B synthesis in the rat anterior pituitary gland. Endocrinology. 1992 Apr;130(4):1829-36. PubMed PMID: 1547712.

17: Ignatjev I, Podstawka-Proniewicz E, Niaura G, Lombardi JR, Proniewicz LM. Potential induced changes in neuromedin B adsorption on Ag, Au, and Cu electrodes monitored by surface-enhanced Raman scattering. J Phys Chem B. 2011 Sep 8;115(35):10525-36. doi: 10.1021/jp2026863. Epub 2011 Aug 16. PubMed PMID: 21812441.

18: Oliveira KJ, Paula GS, Império GE, Bressane NO, Magalhães CM, Miranda-Alves L, Ortiga-Carvalho TM, Pazos-Moura CC. Hypothalamic-pituitary thyroid axis alterations in female mice with deletion of the neuromedin B receptor gene. Regul Pept. 2014 Nov;194-195:30-5. doi: 10.1016/j.regpep.2014.10.002. Epub 2014 Oct 24. PubMed PMID: 25454367.

19: Otsuki M, Fujii M, Nakamura T, Tani S, Oka T, Yajima H, Baba S. Effects of neuromedin B and neuromedin C on exocrine and endocrine rat pancreas. Am J Physiol. 1987 Apr;252(4 Pt 1):G491-8. PubMed PMID: 2436486.

20: Paula GS, Souza LL, Bressane NO, Maravalhas R, Wilieman M, Bento-Bernardes T, Silva KR, Mendonca LS, Oliveira KJ, Pazos-Moura CC. Mice with Deletion of Neuromedin B Receptor Exhibit Decreased Oral Glucose-Stimulated Insulin Release. Horm Metab Res. 2016 Dec;48(12):854-861. Epub 2016 Oct 18. PubMed PMID: 27756093.