WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 559160
CAS#: 52212-91-6
Description: Lankacyclinol A is a Lankacidin Antibiotic.
MedKoo Cat#: 559160
Name: Lankacyclinol A
CAS#: 52212-91-6
Chemical Formula: C26H37NO6
Exact Mass: 459.2621
Molecular Weight: 459.58
Elemental Analysis: C, 67.95; H, 8.12; N, 3.05; O, 20.89
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Synonym: Lankacyclinol A; Antibiotic T 2636 E; T-2636-E; T 2636-E; T2636-E;
IUPAC/Chemical Name: (2E,4E,8E,10E,15E)-7-hydroxy-12-(2-hydroxypropanamido)-4,10,13,15-tetramethyl-14-oxocycloheptadeca-2,4,8,10,15-pentaen-1-yl acetate
InChi Key: CHSNOFZXJPAESZ-KCJBODNSSA-N
InChi Code: InChI=1S/C26H37NO6/c1-16-7-11-22(30)12-8-17(2)15-24(27-26(32)20(5)28)19(4)25(31)18(3)10-14-23(13-9-16)33-21(6)29/h7-10,12-13,15,19-20,22-24,28,30H,11,14H2,1-6H3,(H,27,32)/b12-8+,13-9+,16-7+,17-15+,18-10+
SMILES Code: CC(O)C(NC1/C=C(C)/C=C/C(O)C/C=C(C)/C=C/C(OC(C)=O)C/C=C(C)/C(C1C)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
The following data is based on the product molecular weight 459.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Williams DR, Cortez GS, Bogen SL, Rojas CM. Total Synthesis of Lankacyclinol Generous financial support for this research was provided by the National Institutes of Health (Award no.: GM41560). Additionally, a National Institutes of Health Minority Predoctoral Fellowship (Award no.: GM18547) to G.S.C. is gratefully acknowledged. We also wish to thank Dr. Tsuneaki Hida and Dr. Yoshio Kozai, Takeda Chemical Ltd. (Japan), for providing us with an authentic sample of lankacyclinol as well as copies of the original (1)H NMR spectrum. . Angew Chem Int Ed Engl. 2000 Dec 15;39(24):4612-4615. PubMed PMID: 11169688.
2: Zheng K, Shen D, Hong R. Biomimetic Synthesis of Lankacidin Antibiotics. J Am Chem Soc. 2017 Sep 20;139(37):12939-12942. doi: 10.1021/jacs.7b08500. Epub 2017 Sep 6. PubMed PMID: 28853876.
