Mulberrofuran G

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592463

CAS#: 87085-00-5

Description: Mulberrofuran G is a Tyrosinase Inhibitor.


Chemical Structure

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Mulberrofuran G
CAS# 87085-00-5

Theoretical Analysis

MedKoo Cat#: 592463
Name: Mulberrofuran G
CAS#: 87085-00-5
Chemical Formula: C34H26O8
Exact Mass: 562.1628
Molecular Weight: 562.57
Elemental Analysis: Chemical Formula: C34H26O8 Exact Mass: Molecular Weight: Elemental Analysis: C, 72.59; H, 4.66; O, 22.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Mulberrofuran G; NSC 649229; NSC-649229; NSC649229

IUPAC/Chemical Name: Albanol A

InChi Key: MJJWBJFYYRAYKU-KRNDDSPESA-N

InChi Code: InChI=1S/C34H26O8/c1-16-8-23-22-6-4-21(37)15-30(22)41-34(25-7-5-19(35)13-26(25)38)33(23)24(9-16)32-27(39)10-18(12-31(32)42-34)28-11-17-2-3-20(36)14-29(17)40-28/h2-7,9-15,23-24,33,35-39H,8H2,1H3/t23-,24-,33+,34+/m1/s1

SMILES Code: Oc1ccc(cc(c2cc(O3)c([C@@H]4[C@H]5[C@@]3(c6c(O)cc(O)cc6)Oc7cc(O)ccc7[C@H]5CC(C)=C4)c(O)c2)o8)c8c1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 562.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Koirala P, Seong SH, Zhou Y, Shrestha S, Jung HA, Choi JS. Structure⁻Activity Relationship of the Tyrosinase Inhibitors Kuwanon G, Mulberrofuran G, and Albanol B from Morus Species: A Kinetics and Molecular Docking Study. Molecules. 2018 Jun 11;23(6). pii: E1413. doi: 10.3390/molecules23061413. PubMed PMID: 29891812.

2: Paudel P, Yu T, Seong SH, Kuk EB, Jung HA, Choi JS. Protein Tyrosine Phosphatase 1B Inhibition and Glucose Uptake Potentials of Mulberrofuran G, Albanol B, and Kuwanon G from Root Bark of Morus alba L. in Insulin-Resistant HepG2 Cells: An In Vitro and In Silico Study. Int J Mol Sci. 2018 May 22;19(5). pii: E1542. doi: 10.3390/ijms19051542. PubMed PMID: 29786669; PubMed Central PMCID: PMC5983811.

3: Li M, Wu X, Wang X, Shen T, Ren D. Two novel compounds from the root bark of Morus alba L. Nat Prod Res. 2018 Jan;32(1):36-42. doi: 10.1080/14786419.2017.1327862. Epub 2017 May 19. PubMed PMID: 28521570.

4: Kuk EB, Jo AR, Oh SI, Sohn HS, Seong SH, Roy A, Choi JS, Jung HA. Anti-Alzheimer's disease activity of compounds from the root bark of Morus alba L. Arch Pharm Res. 2017 Mar;40(3):338-349. doi: 10.1007/s12272-017-0891-4. Epub 2017 Jan 16. PubMed PMID: 28093699.

5: Hong S, Kwon J, Kim DW, Lee HJ, Lee D, Mar W. Mulberrofuran G Protects Ischemic Injury-induced Cell Death via Inhibition of NOX4-mediated ROS Generation and ER Stress. Phytother Res. 2017 Feb;31(2):321-329. doi: 10.1002/ptr.5754. Epub 2016 Dec 2. PubMed PMID: 27910195.

6: Ma F, Shen W, Zhang X, Li M, Wang Y, Zou Y, Li Y, Wang H. Anti-HSV Activity of Kuwanon X from Mulberry Leaves with Genes Expression Inhibitory and HSV-1 Induced NF-κB Deactivated Properties. Biol Pharm Bull. 2016;39(10):1667-1674. PubMed PMID: 27725444.

7: Jung JW, Ko WM, Park JH, Seo KH, Oh EJ, Lee DY, Lee DS, Kim YC, Lim DW, Han D, Baek NI. Isoprenylated flavonoids from the root bark of Morus alba and their hepatoprotective and neuroprotective activities. Arch Pharm Res. 2015 Nov;38(11):2066-75. doi: 10.1007/s12272-015-0613-8. Epub 2015 May 16. PubMed PMID: 25981820.

8: Lee HJ, Ryu J, Park SH, Woo ER, Kim AR, Lee SK, Kim YS, Kim JO, Hong JH, Lee CJ. Effects of Morus alba L. and Natural Products Including Morusin on In Vivo Secretion and In Vitro Production of Airway MUC5AC Mucin. Tuberc Respir Dis (Seoul). 2014 Aug;77(2):65-72. doi: 10.4046/trd.2014.77.2.65. Epub 2014 Aug 29. PubMed PMID: 25237377; PubMed Central PMCID: PMC4165662.

9: Abbas GM, Abdel Bar FM, Baraka HN, Gohar AA, Lahloub MF. A new antioxidant stilbene and other constituents from the stem bark of Morus nigra L. Nat Prod Res. 2014;28(13):952-9. doi: 10.1080/14786419.2014.900770. Epub 2014 Mar 28. PubMed PMID: 24673367.

10: Geng CA, Ma YB, Zhang XM, Yao SY, Xue DQ, Zhang RP, Chen JJ. Mulberrofuran G and isomulberrofuran G from Morus alba L.: anti-hepatitis B virus activity and mass spectrometric fragmentation. J Agric Food Chem. 2012 Aug 22;60(33):8197-202. doi: 10.1021/jf302639b. Epub 2012 Aug 8. PubMed PMID: 22835135.

11: Wu D, Zhang X, Huang X, He X, Wang G, Ye W. [Chemical constituents from root barks of Morus atropurpurea]. Zhongguo Zhong Yao Za Zhi. 2010 Aug;35(15):1978-82. Chinese. PubMed PMID: 20931850.

12: Geng C, Yao S, Xue D, Zuo A, Zhang X, Jiang Z, Ma Y, Chen J. New isoprenylated flavonoid from Morus alba. Zhongguo Zhong Yao Za Zhi. 2010 Jun;35(12):1560-5. PubMed PMID: 20815207.

13: Kikuchi T, Nihei M, Nagai H, Fukushi H, Tabata K, Suzuki T, Akihisa T. Albanol A from the root bark of Morus alba L. induces apoptotic cell death in HL60 human leukemia cell line. Chem Pharm Bull (Tokyo). 2010 Apr;58(4):568-71. PubMed PMID: 20410645.

14: Zheng ZP, Cheng KW, Zhu Q, Wang XC, Lin ZX, Wang M. Tyrosinase inhibitory constituents from the roots of Morus nigra: a structure-activity relationship study. J Agric Food Chem. 2010 May 12;58(9):5368-73. doi: 10.1021/jf1003607. PubMed PMID: 20297841.

15: Zhang QJ, Tang YB, Chen RY, Yu DQ. Three new cytotoxic Diels-Alder-type adducts from Morus australis. Chem Biodivers. 2007 Jul;4(7):1533-40. PubMed PMID: 17638335.

16: Kang J, Chen RY, Yu DQ. Five new diels-alder type adducts from the stem and root bark of Morus mongolica. Planta Med. 2006 Jan;72(1):52-9. PubMed PMID: 16450296.

17: Sohn HY, Son KH, Kwon CS, Kwon GS, Kang SS. Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai. Phytomedicine. 2004 Nov;11(7-8):666-72. PubMed PMID: 15636183.

18: Dai SJ, Wu Y, Wang YH, He WY, Chen RY, Yu DQ. New Diels-Alder type adducts from Morus macroura and their anti-oxidant activities. Chem Pharm Bull (Tokyo). 2004 Oct;52(10):1190-3. PubMed PMID: 15467233.

19: Kimura Y, Okuda H, Nomura T, Fukai T, Arichi S. Effects of phenolic constituents from the mulberry tree on arachidonate metabolism in rat platelets. J Nat Prod. 1986 Jul-Aug;49(4):639-44. PubMed PMID: 3097265.

20: Fukai T, Hano Y, Hirakura K, Nomura T, Uzawa J, Fukushima K. Structures of two natural hypotensive Diels-Alder type adducts, mulberrofurans F and G, from the cultivated mulberry tree (Morus lhou KOIDZ.). Chem Pharm Bull (Tokyo). 1985 Aug;33(8):3195-204. PubMed PMID: 4085065.