IEM-1754 2HBr
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563406

CAS#: 162831-31-4

Description: IEM-1754 2HBr is a voltage-dependent open-channel blocker of AMPA receptors. It acts by selectively blocking GluR2 subunit-lacking (Ca2+-permeable) receptors.


Chemical Structure

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IEM-1754 2HBr
CAS# 162831-31-4

Theoretical Analysis

MedKoo Cat#: 563406
Name: IEM-1754 2HBr
CAS#: 162831-31-4
Chemical Formula: C16H32Br2N2
Exact Mass: 410.0932
Molecular Weight: 412.25
Elemental Analysis: C, 46.62; H, 7.82; Br, 38.76; N, 6.80

Price and Availability

Size Price Availability Quantity
10.0mg USD 320.0 2 Weeks
50.0mg USD 890.0 2 Weeks
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Synonym: IEM-1754 dihydrobromide; IEM 1754 dihydrobromide; IEM1754 dihydrobromide; IEM-1754 2HBr; IEM 1754 2HBr; IEM1754 2HBr;

IUPAC/Chemical Name: N-(Tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1,5-pentanediamine dihydrobromide

InChi Key: JMPHTNNJCZDROM-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H30N2.2BrH/c17-4-2-1-3-5-18-12-16-9-13-6-14(10-16)8-15(7-13)11-16;;/h13-15,18H,1-12,17H2;2*1H

SMILES Code: NCCCCCNCC1(C2)CC3CC2CC(C3)C1.[H]Br.[H]Br

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 412.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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7: Magazanik LG, Tikhonov DB, Bol'shakov KV, Gmiro VE, Buldakova SL, Samoilova MV. Studies of the structure of glutamate receptor ion channels and the mechanisms of their blockade by organic cations. Neurosci Behav Physiol. 2003 Mar;33(3):237-46. PubMed PMID: 12762590.

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13: Gmiro VE, Serdiuk SE. [A comparative study of the central H-cholinergic-blocking and NMDA-blocking actions of MK-801, memantin, amantadine, pyrilen and IEM-1754 in experiments on intact rats]. Eksp Klin Farmakol. 2000 Mar-Apr;63(2):16-20. Russian. PubMed PMID: 10834088.

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15: Tikhonov DB, Samoilova MV, Buldakova SL, Gmiro VE, Magazanik LG. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74. PubMed PMID: 10694232; PubMed Central PMCID: PMC1571829.

16: Lukomskaia NIa, Zhabko EP, Gmiro VE. [The participation of glutaminergic transmission in the mechanism of movement disorders induced by reverse rotation in white mice]. Ross Fiziol Zh Im I M Sechenova. 1999 Apr;85(4):497-501. Russian. PubMed PMID: 10513382.

17: Antonov SM, Gmiro VE, Johnson JW. Binding sites for permeant ions in the channel of NMDA receptors and their effects on channel block. Nat Neurosci. 1998 Oct;1(6):451-61. PubMed PMID: 10196542.

18: Magazanik LG, Buldakova SL, Samoilova MV, Gmiro VE, Mellor IR, Usherwood PN. Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J Physiol. 1997 Dec 15;505 ( Pt 3):655-63. PubMed PMID: 9457643; PubMed Central PMCID: PMC1160043.

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