IEM-1754 2HBr

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 563406

CAS#: 162831-31-4

Description: IEM-1754 2HBr is a voltage-dependent open-channel blocker of AMPA receptors. It acts by selectively blocking GluR2 subunit-lacking (Ca2+-permeable) receptors.

Chemical Structure

IEM-1754 2HBr
CAS# 162831-31-4

Theoretical Analysis

MedKoo Cat#: 563406
Name: IEM-1754 2HBr
CAS#: 162831-31-4
Chemical Formula: C16H32Br2N2
Exact Mass: 410.0932
Molecular Weight: 412.25
Elemental Analysis: C, 46.62; H, 7.82; Br, 38.76; N, 6.80

Price and Availability

Size Price Availability Quantity
10.0mg USD 320.0 2 Weeks
50.0mg USD 890.0 2 Weeks
Bulk inquiry

Synonym: IEM-1754 dihydrobromide; IEM 1754 dihydrobromide; IEM1754 dihydrobromide; IEM-1754 2HBr; IEM 1754 2HBr; IEM1754 2HBr;

IUPAC/Chemical Name: N-(Tricyclo[,7]dec-1-ylmethyl)-1,5-pentanediamine dihydrobromide


InChi Code: InChI=1S/C16H30N2.2BrH/c17-4-2-1-3-5-18-12-16-9-13-6-14(10-16)8-15(7-13)11-16;;/h13-15,18H,1-12,17H2;2*1H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 412.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Vataev SI, Oganesian GA, Lukomskaia NIa, Magazanik LG. [The action of ionotropic glutamate receptor channel blockers on effects of sleep deprivation in rats]. Ross Fiziol Zh Im I M Sechenova. 2013 May;99(5):575-85. Russian. PubMed PMID: 24459868.

2: Vataev SI, Oganesian GA, Gmiro VE, Lukomskaia NIa, Magazanik LG. [Effects of ionotropic glutamate receptor channel blockers ON sleep-waking organization in rats]. Ross Fiziol Zh Im I M Sechenova. 2012 Jul;98(7):809-18. Russian. PubMed PMID: 23074828.

3: Lukomskaia NIa, Vataev SI, Zhabko EP, Magazanik LG. [Effects of ionotropic glutamate receptor channel blockers on the development of audiogenic seizures in Krushinski-Molodkina rats]. Ross Fiziol Zh Im I M Sechenova. 2012 Apr;98(4):449-60. Russian. PubMed PMID: 22834334.

4: Kaczor AA, Kijkowska-Murak UA, Matosiuk D. Theoretical studies on the structure and symmetry of the transmembrane region of glutamatergic GluR5 receptor. J Med Chem. 2008 Jul 10;51(13):3765-76. doi: 10.1021/jm7011694. Epub 2008 Jun 10. PubMed PMID: 18540667.

5: Serdyuk SE, Gmiro VE. Combined blockade of alpha3beta4 nicotinic acetylcholine receptors and GluR1 AMPA receptors in rats prevents kainate-induced tonic-clonic seizures. Bull Exp Biol Med. 2007 May;143(5):611-3. PubMed PMID: 18239782.

6: Lukomskaya NY, Rukoyatkina NI, Gorbunova LV, Gmiro VE, Bol'shakov KV, Magazanik LG. Comparison of the anticonvulsive activities of organic mono- and dications with their abilities to inhibit NMDA and AMPA glutamate receptors. Neurosci Behav Physiol. 2004 Feb;34(2):181-7. PubMed PMID: 15115325.

7: Magazanik LG, Tikhonov DB, Bol'shakov KV, Gmiro VE, Buldakova SL, Samoilova MV. Studies of the structure of glutamate receptor ion channels and the mechanisms of their blockade by organic cations. Neurosci Behav Physiol. 2003 Mar;33(3):237-46. PubMed PMID: 12762590.

8: Lukomskaia NIa, Rukoiatkina NI, Gorbunova LV, Gmiro VE, Bol'shakov KV, Magazanik LG. [Comparison of the anticonvulsant activity of organic mono- and di-cations and their potential to inhibit NMDA and AMPA glutamate receptors]. Ross Fiziol Zh Im I M Sechenova. 2002 Sep;88(9):1161-71. Russian. PubMed PMID: 12503423.

9: Magazanik LG, Tikhonov DB, Bol'shakov KB, Gmiro VE, Buldakova SL, Samoĭlova MV. [Structure of glutamate receptor ion channels and mechanisms of their blockade by organic cations]. Ross Fiziol Zh Im I M Sechenova. 2001 Aug;87(8):1026-39. Russian. PubMed PMID: 11601147.

10: Lukomskaya NY, Zhabko EP, Gmiro VE. The involvement of glutamatergic transmission in the mechanism of movement disorders induced by reversive rotation of white mice. Neurosci Behav Physiol. 2000 Sep-Oct;30(5):543-6. PubMed PMID: 11037145.

11: Rukoiatkina NI, Gorbunova LV, Gmiro VE, Lukomskaia NIa. [Glutamate receptor antagonists attenuate experimental catalepsy in rats]. Ross Fiziol Zh Im I M Sechenova. 2000 Jun;86(6):626-33. Russian. PubMed PMID: 10955300.

12: Gmiro VE, Serdiuk SE. [Bis-ammonium adamantane derivatives--novel modulators of polyamine binding sites]. Eksp Klin Farmakol. 2000 May-Jun;63(3):16-20. Russian. PubMed PMID: 10934589.

13: Gmiro VE, Serdiuk SE. [A comparative study of the central H-cholinergic-blocking and NMDA-blocking actions of MK-801, memantin, amantadine, pyrilen and IEM-1754 in experiments on intact rats]. Eksp Klin Farmakol. 2000 Mar-Apr;63(2):16-20. Russian. PubMed PMID: 10834088.

14: Gmiro VE, Serdiuk SE. [The search for selective blockers of NMDA and AMPA/kainate receptors in a series of bis-ammonium compounds with adamantyl radicals]. Eksp Klin Farmakol. 2000 Jan-Feb;63(1):7-13. Russian. PubMed PMID: 10763102.

15: Tikhonov DB, Samoilova MV, Buldakova SL, Gmiro VE, Magazanik LG. Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br J Pharmacol. 2000 Jan;129(2):265-74. PubMed PMID: 10694232; PubMed Central PMCID: PMC1571829.

16: Lukomskaia NIa, Zhabko EP, Gmiro VE. [The participation of glutaminergic transmission in the mechanism of movement disorders induced by reverse rotation in white mice]. Ross Fiziol Zh Im I M Sechenova. 1999 Apr;85(4):497-501. Russian. PubMed PMID: 10513382.

17: Antonov SM, Gmiro VE, Johnson JW. Binding sites for permeant ions in the channel of NMDA receptors and their effects on channel block. Nat Neurosci. 1998 Oct;1(6):451-61. PubMed PMID: 10196542.

18: Magazanik LG, Buldakova SL, Samoilova MV, Gmiro VE, Mellor IR, Usherwood PN. Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J Physiol. 1997 Dec 15;505 ( Pt 3):655-63. PubMed PMID: 9457643; PubMed Central PMCID: PMC1160043.

19: Magazanik LG, Samoĭlova MV, Buldakova SL, Esin KV, Gmiro VE. Selective block of AMPA/kainate receptors of hippocampal interneurons as a new approach to the investigation of inhibitory system. Ross Fiziol Zh Im I M Sechenova. 1997 May-Jun;83(5-6):19-39. English, Russian. PubMed PMID: 13677665.

20: Antonov SM, Johnson JW. Voltage-dependent interaction of open-channel blocking molecules with gating of NMDA receptors in rat cortical neurons. J Physiol. 1996 Jun 1;493 ( Pt 2):425-45. PubMed PMID: 8782107; PubMed Central PMCID: PMC1158928.