WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 592455

CAS#: 555-29-3

Description: alpha-Methyldopa is an alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.

Chemical Structure

CAS# 555-29-3

Theoretical Analysis

MedKoo Cat#: 592455
Name: alpha-Methyldopa
CAS#: 555-29-3
Chemical Formula: C10H13NO4
Exact Mass: 211.0845
Molecular Weight: 211.22
Elemental Analysis: C, 56.87; H, 6.20; N, 6.63; O, 30.30

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: alpha-Methyldopa; Metholes; Mulfasin

IUPAC/Chemical Name: 3-Hydroxy-alpha-methyl-DL-tyrosine


InChi Code: InChI=1S/C10H13NO4/c1-10(11,9(14)15)5-6-2-3-7(12)8(13)4-6/h2-4,12-13H,5,11H2,1H3,(H,14,15)

SMILES Code: NC(CC1=CC=C(O)C(O)=C1)(C)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

Preparing Stock Solutions

The following data is based on the product molecular weight 211.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

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1: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from PubMed PMID: 30000085.

2: Schneider F, Erisson L, Beygi H, Bradbury M, Cohen-Barak O, Grachev ID, Guzy S, Loupe PS, Levi M, McDonald M, Savola JM, Papapetropoulos S, Tracewell WG, Velinova M, Spiegelstein O. Pharmacokinetics, Metabolism and Safety of Deuterated L-DOPA (SD-1077)/Carbidopa (CD) Compared to L-DOPA/CD following single oral dose administration in Healthy Subjects. Br J Clin Pharmacol. 2018 Jun 29. doi: 10.1111/bcp.13702. [Epub ahead of print] PubMed PMID: 29959802.

3: Bortolotto MR, Francisco RPV, Zugaib M. Resistant Hypertension in Pregnancy: How to Manage? Curr Hypertens Rep. 2018 Jun 11;20(8):63. doi: 10.1007/s11906-018-0865-z. Review. PubMed PMID: 29892919.

4: Zakiyah N, Ter Heijne LF, Bos JH, Hak E, Postma MJ, Schuiling-Veninga CCM. Antidepressant use during pregnancy and the risk of developing gestational hypertension: a retrospective cohort study. BMC Pregnancy Childbirth. 2018 May 29;18(1):187. doi: 10.1186/s12884-018-1825-y. PubMed PMID: 29843629; PubMed Central PMCID: PMC5975401.

5: Belal F, Ibrahim F, Sheribah ZA, Alaa H. Micellar HPLC-UV method for the simultaneous determination of levodopa, carbidopa and entacapone in pharmaceuticals and human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 1;1091:36-45. doi: 10.1016/j.jchromb.2018.05.030. Epub 2018 May 22. PubMed PMID: 29843067.

6: Norman K, Nappe TM. Toxicity, Alpha Receptor Agonists. 2018 May 10. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2018 Jan-. Available from PubMed PMID: 29763199.

7: Amoateng P, Kukuia KKE, Mensah JA, Osei-Safo D, Adjei S, Eklemet AA, Vinyo EA, Karikari TK. An extract of Synedrella nodiflora (L) Gaertn exhibits antidepressant properties through monoaminergic mechanisms. Metab Brain Dis. 2018 May 12. doi: 10.1007/s11011-018-0244-0. [Epub ahead of print] PubMed PMID: 29754167.

8: Ikeda M, Iijima H, Shinoda I, Iwamoto H, Takeda Y. Effects of bovine lactoferrin on l-DOPA absorption and metabolism in mice. Food Funct. 2018 May 23;9(5):2865-2871. doi: 10.1039/c7fo01518f. PubMed PMID: 29707715.

9: Antunes RS, Garcia LF, Somerset VS, Gil ES, Lopes FM. The Use of a Polyphenoloxidase Biosensor Obtained from the Fruit of Jurubeba (Solanum paniculatum L.) in the Determination of Paracetamol and Other Phenolic Drugs. Biosensors (Basel). 2018 Apr 2;8(2). pii: E36. doi: 10.3390/bios8020036. PubMed PMID: 29614829; PubMed Central PMCID: PMC6023012.

10: Ostrov DA, Alkanani A, McDaniel KA, Case S, Baschal EE, Pyle L, Ellis S, Pöllinger B, Seidl KJ, Shah VN, Garg SK, Atkinson MA, Gottlieb PA, Michels AW. Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes. J Clin Invest. 2018 May 1;128(5):1888-1902. doi: 10.1172/JCI97739. Epub 2018 Apr 3. PubMed PMID: 29438107; PubMed Central PMCID: PMC5919818.

11: El-Sayeh HG, Rathbone J, Soares-Weiser K, Bergman H. Non-antipsychotic catecholaminergic drugs for antipsychotic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2018 Jan 18;1:CD000458. doi: 10.1002/14651858.CD000458.pub3. Review. PubMed PMID: 29342497.

12: Nakuz TS, Berger E, El-Rabadi K, Wadsak W, Haug A, Hacker M, Karanikas G. Clinical Value of (18)F-FDOPA PET/CT With Contrast Enhancement and Without Carbidopa Premedication in Patients with Insulinoma. Anticancer Res. 2018 Jan;38(1):353-358. PubMed PMID: 29277794.

13: Ward K, Citrome L. Lisdexamfetamine: chemistry, pharmacodynamics, pharmacokinetics, and clinical efficacy, safety, and tolerability in the treatment of binge eating disorder. Expert Opin Drug Metab Toxicol. 2018 Feb;14(2):229-238. doi: 10.1080/17425255.2018.1420163. Epub 2018 Jan 4. Review. PubMed PMID: 29258368.

14: Marshall T, Pugh A, Fairchild A, Hass S. Patient Preferences for Device-Aided Treatments Indicated for Advanced Parkinson Disease. Value Health. 2017 Dec;20(10):1383-1393. doi: 10.1016/j.jval.2017.06.001. Epub 2017 Jul 20. PubMed PMID: 29241898.

15: Eichler FS, Swoboda KJ, Hunt AL, Cestari DM, Rapalino O. Case 38-2017. A 20-Year-Old Woman with Seizures and Progressive Dystonia. N Engl J Med. 2017 Dec 14;377(24):2376-2385. doi: 10.1056/NEJMcpc1706109. PubMed PMID: 29236641.

16: Safari F, Keyvanfard M, Karimi-Maleh H, Alizad K. Voltammetric Determination of Penicillamine Using a Carbon Paste Electrode Modified with Multiwall Carbon Nanotubes In the Presence of Methyldopa as a Mediator. Iran J Pharm Res. 2017 Summer;16(3):1019-1029. PubMed PMID: 29201090; PubMed Central PMCID: PMC5610756.

17: Granados A, Olmo AD, Peccati F, Billard T, Sodupe M, Vallribera A. Fluorous l-Carbidopa Precursors: Highly Enantioselective Synthesis and Computational Prediction of Bioactivity. J Org Chem. 2018 Jan 5;83(1):303-313. doi: 10.1021/acs.joc.7b02685. Epub 2017 Dec 21. PubMed PMID: 29200295.

18: de Oliveira-Filho AD, Vieira AES, da Silva RC, Neves SJF, Gama TAB, Lima RV, Oliveira WR, de Gonçalves Dias JM. Adverse drug reactions in high-risk pregnant women: A prospective study. Saudi Pharm J. 2017 Nov;25(7):1073-1077. doi: 10.1016/j.jsps.2017.01.005. Epub 2017 Feb 2. PubMed PMID: 29158717; PubMed Central PMCID: PMC5681315.

19: Safe S. Carbidopa: a selective Ah receptor modulator (SAhRM). Biochem J. 2017 Nov 6;474(22):3763-3765. doi: 10.1042/BCJ20170728. PubMed PMID: 29109131.

20: Willows T, Dizdar N, Nyholm D, Widner H, Grenholm P, Schmiauke U, Urbom A, Groth K, Larsson J, Permert J, Kjellander S. Initiation of Levodopa-Carbidopa Intestinal Gel Infusion Using Telemedicine (Video Communication System) Facilitates Efficient and Well-Accepted Home Titration in Patients with Advanced Parkinson's Disease. J Parkinsons Dis. 2017;7(4):719-728. doi: 10.3233/JPD-161048. PubMed PMID: 28984615; PubMed Central PMCID: PMC5676855.